Published in:
01-06-2021 | Ulcerative Colitis | Original Article
Extraintestinal Manifestations in Patients with Inflammatory Bowel Disease: Study Based on the ENEIDA Registry
Authors:
Alicia Algaba, Iván Guerra, Elena Ricart, Eva Iglesias, Miriam Mañosa, Javier P. Gisbert, Jordi Guardiola, Miguel Mínguez, Beatriz Castro, Ruth de Francisco, Pilar Nos, Federico Bertoletti, Francisco Mesonero, Jesús Barrio, María Dolores Martín-Arranz, Xavier Calvet, Santiago García-López, Beatriz Sicilia, Gillermo Alcaín, María Esteve, Lucía Márquez, Marta Piqueras, Laura Jiménez, José L. Perez-Calle, Luis Bujanda, Mariana García-Sepulcre, Alejandra Fernández, Irene Moraleja, Rufo Humberto Lorente, Orlando García-Bosch, Ana Lambán, Isabel Blázquez, Esther Rodríguez, José M. Huguet, Alfredo J. Lucendo, Pedro Almela, David Busquets, Patricia Ramírez de la Piscina, Marcela Pérez, Eugeni Domenech, Fernando Bermejo, the Spanish GETECCU Group (ENEIDA Project)
Published in:
Digestive Diseases and Sciences
|
Issue 6/2021
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Abstract
Background
Patients with inflammatory bowel disease (IBD) may present extraintestinal manifestations (EIMs) that affect the joints, skin, eyes, and hepatobiliary area, among others.
Aims
Our aim was to analyse the prevalence and characteristics of EIMs in patients with IBD and to identify the possible risk factors associated with the development of EIMs in the largest series published to date.
Methods
Observational, cross-sectional study including patients from the Spanish ENEIDA registry promoted by GETECCU. We retrospectively identified all cases of EIMs in the ENEIDA registry until January 2018.
Results
The study included 31,077 patients, 5779 of whom had at least one EIM (global prevalence 19%; 95% CI 18.2–19.0). Among the different types of EIMs, rheumatic manifestations had a prevalence of 13% (95% CI 12.9–13.7; 63% of EIMs), with a prevalence of 5% (95% CI 4.7–5.2) for mucocutaneous manifestations, 2.1% (95% CI 1.9–2.2) for ocular manifestations, and 0.7% (95% CI 0.6–0.8) for hepatobiliary manifestations. The multivariable analysis showed that the type of IBD (Crohn’s disease, p < 0.001), gender (female, p < 0.001), the need for an immunomodulator (p < 0.001) or biologic drugs (p < 0.001), a previous family history of IBD (p < 0.001), and an extensive location of IBD (p < 0.001) were risk factors for the presence of EIMs.
Conclusions
One-fifth of patients with IBD may have associated EIMs, with rheumatic manifestations as the most frequent (> 60% of EIMs). Female patients with severe Crohn’s disease represent the group with the highest risk of developing EIMs. These patients should therefore be specially monitored and referred to the corresponding specialist when suggestive symptoms appear.