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Cholangitis 

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  1. Open Access 01-12-2024 | Primary Sclerosing Cholangitis | OriginalPaper

    Genetically predicted gut microbiota mediate the association between plasma lipidomics and primary sclerosing cholangitis

    Primary sclerosing cholangitis (PSC) is a rare and chronic cholestatic liver disease characterized by intrahepatic or extrahepatic stricturing, or both, accompanied by bile duct fibrosis [ 1 ]. Its prevalence is highest in northern Europe and lower …

  2. 07-05-2024 | Primary Sclerosing Cholangitis | Online First

    What is the appropriate method of pathological specimen collection for cholangiocarcinoma detection in primary sclerosing cholangitis?

    Primary sclerosing cholangitis (PSC) is characterized pathologically by chronic inflammation and fibrosis and clinically by chronic biliary stasis [ 1 ]. As the disease progresses, diffuse stricture and wall thickening appear in the bile ducts …

  3. Open Access 01-12-2024 | Cholangitis | OriginalPaper

    Catharanthus roseus intoxication mimicking acute cholangitis

    Catharanthus roseus is a species of flowering plant classified within the family Apocynaceae. Belonging to the genus Catharanthus, this plant is characterized by its glossy leaves and vibrant, pinwheel-like flowers. Native to Madagascar, it has …

  4. Open Access 01-12-2024 | Sarcopenia | OriginalPaper

    Imaging-based diagnosis of sarcopenia for transplant-free survival in primary sclerosing cholangitis

    Determining the prognosis of patients with primary sclerosing cholangitis (PSC) is challenging. The natural history of patients with PSC is variable but frequently culminates in end-stage liver disease. The clinical course of PSC is complicated by …

  5. 23-04-2024 | Langerhans Cell Histiocytosis | Online First

    Adult Langerhans Cell Histiocytosis Presenting With Skin Lesions, Sclerosing Cholangitis and Pneumothorax

  6. 03-01-2024 | Primary Sclerosing Cholangitis | OriginalPaper

    An atypical case of isolated immunoglobulin G4-related sclerosing cholangitis with a cholangiogram resembling primary sclerosing cholangitis

    An asymptomatic 77-year-old man with intrahepatic bile duct dilation was referred to our hospital. Cholangiography revealed alternations between strictures and dilated segments from the right and left hepatic ducts to the lower bile ducts, with …

  7. 12-02-2024 | Primary Sclerosing Cholangitis | EditorialNotes

    Risk Stratification in Primary Sclerosing Cholangitis: Does Size Matter?

  8. 12-02-2024 | Primary Sclerosing Cholangitis | OriginalPaper

    Primary Sclerosing Cholangitis Limited to Intrahepatic Bile Ducts Has Distinctly Better Prognosis

    Primary sclerosing cholangitis (PSC) is a chronic liver disease where inflammation and fibrosis lead to multifocal biliary strictures and cirrhosis [ 1 – 5 ]. Based on the bile duct involvement, PSC is usually classified into the “classic” …

  9. Open Access 25-03-2024 | Cholangitis | Online First

    COVID-19-associated secondary sclerosing cholangitis with liver transplantation

    We report on two cases of orthotopic liver transplantation (OLTX) due to SARS-Cov2-associated secondary sclerosing cholangitis (SSC) following long-term artificial respiration and extra-corporal membrane oxygenation in intensive care. Under these …

  10. 30-03-2024 | Primary Biliary Cholangitis | Online First

    Osteoporosis and Primary Biliary Cholangitis: A Trans-ethnic Mendelian Randomization Analysis

    Osteoporosis is a major clinical problem in many autoimmune diseases, including primary biliary cholangitis (PBC), the most common autoimmune liver disease. Osteoporosis is a major cause of fracture and related mortality. However, it remains …

  11. 07-04-2024 | Cholangitis | Online First

    A case of recurrent follicular cholangitis leading to decompensated cirrhosis after left-sided hepatectomy

    Follicular cholangitis (FC) is a rare non-neoplastic biliary tract disease first reported in 2003. A 74-year-old woman underwent extended left hepatectomy with a diagnosis of intrahepatic cholangiocarcinoma. Histopathological examination of the …

  12. 27-03-2024 | Primary Biliary Cholangitis | Online First

    Primary Biliary Cholangitis: Updates in Management and Goals of Treatment

    Primary Biliary Cholangitis (PBC) is a liver disease characterized by a chronic autoimmune T-cell medicated destruction of intrahepatic bile ducts. PBC has a hallmark autoantibody, anti-mitochondrial antibody (AMA), which is positive in 95% of …

  13. 22-03-2024 | Primary Sclerosing Cholangitis | Online First

    Primary Sclerosing Cholangitis: Gender Effects in Valencia’s Low-Prevalence Region

    Primary sclerosing cholangitis (PSC) is a chronic disease characterized by inflammation and fibrotic obliteration of the intra- and extrahepatic bile ducts, which causes long-term cholestasis and liver fibrosis. It is more commonly observed in the …

  14. 21-03-2024 | Primary Sclerosing Cholangitis | Online First

    Spontaneous perforation of the common bile duct: an uncommon complication of primary sclerosing cholangitis

    Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic disorder of poorly understood etiology, characterized by inflammatory and fibrosing lesions of the intra- and/or extra-hepatic bile ducts [ 1 – 5 ].

  15. 08-03-2024 | Cholangitis | Online First

    Bile Culture May Guide Antibiotic Stewardship in Acute Bacterial Cholangitis

    Acute cholangitis results from a bacterial infection in an obstructed biliary system [ 1 ]. Early administration of antimicrobials and decompression of the biliary are the mainstay of therapy.[ 2 – 4 ] The initial antibiotic is prescribed …

  16. Open Access 01-12-2024 | Primary Biliary Cholangitis | OriginalPaper

    Multi-omics approaches for drug-response characterization in primary biliary cholangitis and autoimmune hepatitis variant syndrome

    Autoimmune hepatitis (AIH) is a severe and chronic progressive inflammatory liver ailment characterized by an enduring autoimmune response directed against liver autoantigens [ 1 , 2 ]. Primary cholestatic hepatitis (PBC) manifests as a chronic …

  17. 11-11-2023 | Primary Sclerosing Cholangitis | OriginalPaper

    Proteome-wide Mendelian randomization highlights AIF1 and HLA-DQA2 as targets for primary sclerosing cholangitis

    Primary sclerosing cholangitis (PSC) is a kind of rare cholestatic liver disease characterized by intrahepatic or extrahepatic (or both) bile duct structuring which is caused by the inflammation and fibrosis of the bile duct, accompanied by …

  18. Open Access 01-12-2024 | Primary Biliary Cholangitis | OriginalPaper

    The effects of low-dose IL-2 on Th17/Treg cell imbalance in primary biliary cholangitis mouse models

    Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by progressive nonsuppurative cholangitis [ 1 ]. Without pharmacological interventions, patients can progress to liver cirrhosis and hepatocellular carcinoma.

  19. Open Access 01-12-2024 | Primary Sclerosing Cholangitis | OriginalPaper

    Investigating the shared genetic architecture between primary sclerosing cholangitis and inflammatory bowel diseases: a Mendelian randomization study

    Inflammatory bowel disease (IBD) is a chronic intestinal disorder with unknown etiology. Many studies point to the presence of genetic predisposition, intestinal mucosal immune system dysfunction, and microbiota imbalance [ 1 ] in the occurrence …

  20. Open Access 01-12-2024 | Cholangitis | OriginalPaper

    Cholangitis with bacteremia due to Pseudomonas nitroreducens in a patient with pancreatic neuroendocrine tumors: a case report

    Pseudomonas nitroreducens is a gram-negative, motile, aerobic, rod-shaped, synchrotrophic bacterium inhabiting soils such as oil brines, paddy field drainage, and river sediments [ 1 – 3 ]. P. nitroreducens is well-known for its ability to …

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