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496 search results for:

Xanthine Alkaloid 

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  1. Open Access 01-12-2024 | Gout | ReviewPaper

    Correlation between gout and dry eye disease

    Gouty arthritis is the most common type of inflammatory arthritis in adults, and its incidence and prevalence have been increasing in recent years [ 1 ]. Gout is an inflammatory arthritis caused by the deposition of monosodium urate crystals in …

  2. 01-04-2024 | Febuxostat | News

    Febuxostat

    Nephrolithiasis
  3. 31-03-2024 | Gout | Online First

    Anti-gouty arthritis and anti-inflammatory effects of curcumin nanoparticles in monosodium urate crystals induced Balb/C mice

    Gout is a metabolic condition characterized by the accumulation of urate crystals in the synovial joints. These crystal depositions result in joint swelling and increased concentration of serum uric acid in blood. The commercially available drugs …

  4. Open Access 01-12-2024 | Influenza | OriginalPaper

    Anti-rheumatic colchicine phytochemical exhibits potent antiviral activities against avian and seasonal Influenza A viruses (IAVs) via targeting different stages of IAV replication cycle

    Influenza is a highly contagious respiratory tract infection that threatens the lives of many people all over the world [ 1 ]. Influenza viruses (IVs) possess a segmented RNA genome of negative sense [ 2 ]. They belong to the Orthomyxoviridae …

  5. 26-12-2023 | Respiratory Microbiota | OriginalPaper

    The anti-hyperuricemic and gut microbiota regulatory effects of a novel purine assimilatory strain, Lactiplantibacillus plantarum X7022

    Hyperuricemia is a metabolic disease related with high level of serum uric acid (UA), which is the end product of purine metabolism [ 1 ]. Gout is a common clinical symptom in hyperuricemia, which is caused by the continuous accumulation of UA to …

  6. 06-03-2024 | Xanthine Alkaloid | Online First

    Causality of blood metabolites and metabolic pathways on Graves’ disease and Graves’ ophthalmopathy: a two-sample Mendelian randomization study

    Graves’ disease (GD) is an autoimmune disorder known as the most common cause of hyperthyroidism; its global prevalence is 2% in females and 0.5% in males [ 1 ]. Graves’ ophthalmopathy (GO), also referred to as thyroid-associated ophthalmopathy …

  7. 20-03-2024 | Events

    Abstracts

  8. Open Access 25-03-2024 | Rheumatoid Arthritis | Online First

    Pathophysiology, diagnosis, and herbal medicine-based therapeutic implication of rheumatoid arthritis: an overview

    Rheumatoid arthritis (RA) stands as an autoimmune disorder characterized by chronic joint inflammation, resulting in profound physiological alterations within the body. Affecting approximately 0.4–1.3% of the global population, this condition …

  9. 11-01-2024 | Allopurinol | Online First

    Hypoxia-Mediated Upregulation of Xanthine Oxidoreductase Causes DNA Damage of Colonic Epithelial Cells in Colitis

    Xanthine oxidoreductase (XOR) serves as the primary source of hydrogen peroxide and superoxide anions in the intestinal mucosa. However, its specific contribution to the progression of colonic disease remains unclear. In this study, we …

  10. 01-01-2024 | Breast Cancer | OriginalPaper

    Chitosan-encapsulated naringenin promotes ROS mediated through the activation of executioner caspase-3

    We previously reported that chitosan nanoparticle-encapsulated Naringenin (CS-NPs/NAR) could scavenge free radicals at lower doses and be cytotoxic to cancer cells. The current study continues to focus on the mechanism behind CS-NPs/NAR-induced …

  11. 01-12-2023 | Xanthine Alkaloid | OriginalPaper

    Temporal change of serum xanthine oxidase levels and its relation to clinical outcome of severe traumatic brain injury: a prospective cohort study

    Xanthine oxidase (XO) may be involved in the induction of oxidative stress and inflammation. We measured serum XO levels at multiple days to determine whether it is associated with the severity and prognosis of severe traumatic brain injury …

  12. Open Access 01-12-2024 | Central Nervous System Trauma | ReviewPaper

    Intranasal delivery of mitochondria targeted neuroprotective compounds for traumatic brain injury: screening based on pharmacological and physiological properties

    Targeting drugs to the mitochondrial level shows great promise for acute and chronic treatment of traumatic brain injury (TBI) in both military and civilian sectors. Perhaps the greatest obstacle to the successful delivery of drug therapies is the …

  13. Open Access 01-12-2024 | Heart Failure | ReviewPaper

    Research advances on molecular mechanism and natural product therapy of iron metabolism in heart failure

    The progression of heart failure (HF) is complex and involves multiple regulatory pathways. Iron ions play a crucial supportive role as a cofactor for important proteins such as hemoglobin, myoglobin, oxidative respiratory chain, and DNA …

  14. Open Access 01-12-2023 | Xanthine Alkaloid | OriginalPaper

    Plasma metabolomics profiles in Black and White participants of the Adventist Health Study-2 cohort

    Black or African Americans suffer persistent disparities in cardiovascular and metabolic diseases, particularly higher morbidity and mortality from these diseases, in spite of downward trends in the general US population. For example, while …

  15. Open Access 01-12-2023 | Neuromyelitis Optica Spectrum Disease | OriginalPaper

    Integrative analysis of purine metabolites and gut microbiota in patients with neuromyelitis optica spectrum disorders after mycophenolate mofetil treatment

    Neuromyelitis optica spectrum disorders (NMOSD) is a severe, disabling autoimmune disease of the central nervous system (CNS) characterized by its association with serum anti-aquaporin-4 antibodies (AQP4-IgG) [ 1 – 4 ]. Clinically, NMOSD results in …

  16. Open Access 01-12-2023 | Septicemia | OriginalPaper

    Xanthine oxidoreductase gene polymorphisms are associated with high risk of sepsis and organ failure

    Sepsis is an organ dysfunction syndrome in response to intravascular or extra-vascular microbial agents. Sepsis is a serious public health problem in the United States and globally [ 1 – 3 ], with an associated mortality above 30% [ 4 , 5 ]. Recent …

  17. Open Access 01-12-2024 | ReviewPaper

    Pharmacological and cell-based treatments to increase local skin flap viability in animal models

    Local skin flaps are frequently employed for wound closure to address surgical, traumatic, congenital, or oncologic defects. (1) Despite their clinical utility, skin flaps may fail due to inadequate perfusion, ischemia/reperfusion injury (IRI) …

  18. 08-05-2023 | Xanthine Alkaloid | Letter

    Linagliptin possibly enhances the efficacy of allosteric xanthine oxidase inhibitors

  19. 01-12-2024 | Rheumatoid Arthritis | ReviewPaper

    Natural Products and Traditional Herbal Medicines as Managerial Therapies to Combat Rheumatoid Arthritis

    Rheumatoid arthritis (RA) is a complex and challenging autoimmune disease characterized by chronic inflammation of the joints, discomfort, stiffness, functional impairment, and systemic complications that affect millions of people around the …

  20. 11-10-2023 | Gout | ReviewPaper

    Emerging Urate-Lowering Drugs and Pharmacologic Treatment Strategies for Gout: A Narrative Review

    Hyperuricemia with consequent monosodium urate crystal deposition leads to gout, characterized by painful, incapacitating inflammatory arthritis flares that are also associated with increased cardiovascular event and related mortality risk. This …

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