Transfusion reactions induced by platelet transfusions may be reduced and alleviated by leukocyte reduction of platelets. Although leukoreduction of apheresis platelets can be performed either pre-storage or post-storage, seldom studies directly …

Thrombocytopenia, usually defined as a platelet count < 150 × 10 9 /L, occurs frequently in intensive care unit (ICU) patients [ 1 , 2 ]. It is often multifactorial with causes including conditions and interventions resulting in reduced platelet …

Thrombocytopenia is frequent in critically ill patients and is associated with an increased risk of bleeding complications [ 1 ]. As a consequence, platelet transfusions are given to thrombocytopenic patients to prevent spontaneous bleeding or …

Platelet transfusions can be administered prophylactically or therapeutically to prevent or control bleeding, respectively, in patients with low platelet counts (thrombocytopenia). Platelet products can be obtained in two ways. Apheresis platelets …

Hemorrhage is an important and frequent complication during extracorporeal membrane oxygenation (ECMO). Although changes in anticoagulation strategies and improved circuit technology have led to a reduction in its occurrence rate, it remains a …

Platelet transfusions (PTx) are the principal approach for treating neonatal thrombocytopenia, a common hematological abnormality affecting neonates, particularly preterm infants. However, evidence about the outcomes associated with PTx and …

Aplastic anemia (AA) is an intractable hematologic disease characterized by empty bone marrow that results in pancytopenia with decreased levels of platelets, white blood cells, and erythrocytes [ 1 , 2 ]. There are three possible …

The study’s main strength is the implementation of a promising and secure therapy approach for patients suffering from severe bleeding. This is a prospective, randomised, double-blind, placebo-controlled clinical trial for data of high-quality …

Acute post-traumatic haemorrhage is the first cause of preventable death [ 1 , 2 ]. Deaths from haemorrhage occur early, typically within the first 6 h. Trauma-induced coagulopathy (TIC) is a complex, multifactorial failure of haemostasis that …

We designed a study to describe the incidence of intracranial hemorrhage according to severity and duration of thrombocytopenia and to quantify the associations of platelet transfusions with intracranial hemorrhage in patients with acute leukemia.

Physiologically, upon platelet activation, uncontrolled propagation of thrombosis is prevented by regulating mechanisms which affect the expression and function of either platelet adhesion receptors or integrins. Receptor ectodomain shedding is an …

Given the rising prevalence of antiplatelet therapy, rapid preoperative identification of patients with bleeding diathesis is necessary for the guidance of blood product administration. This is especially relevant in neurosurgery for intracranial …

Blood component transfusion is used widely in healthcare and is life-saving in many clinical settings such as trauma, critical care (CC) and haemato-oncology (HO). The transfusion of blood components has known risks of harm if used unnecessarily.

Many patients with acute coronary syndrome (ACS) and severe multi-vessel disease are offered non-elective coronary artery bypass grafting (CABG) within a short period of time since their last episode of chest pain [ 1 ]. The use of adenosine …