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Aplastic Anemia 

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  1. 22-04-2024 | Aplastic Anemia | Online First

    Mendelian randomization of circulating proteome identifies IFN-γ as a druggable target in aplastic anemia

    Aplastic anemia (AA) is a kind of bone marrow failure (BMF) characterized by pancytopenia with a hypoplasia/aplasia bone marrow [ 1 ]. Patients with AA present with infections due to neutropenia, bleeding due to thrombocytopenia, and/or fatigue due …

  2. Open Access 05-04-2024 | Aplastic Anemia | Online First

    Quality of life after immune suppressive therapy in aplastic anemia

    Acquired aplastic anemia (AA) is a rare form of immune-mediated bone marrow failure, which can result in life-threatening infections or bleeding if left untreated. Treatment consists of either immune suppressive therapy (IST) or allogeneic stem …

  3. 02-02-2024 | Aplastic Anemia | Letter

    Loeys-Dietz syndrome with concomitant aplastic anemia

    An 18-year-old female, who had a 2-week complaint of generalized pruritus was referred to our clinic in March 2021. Her blood count showed white blood cells of 1.6 × 10 9 /L, absolute neutrophil count 0.9 × 10 9 /L, hemoglobin 70 g/L, and platelet …

  4. 24-04-2024 | Aplastic Anemia | Online First

    Unrelated umbilical cord blood transplantation with low-dose anti-thymocyte globulin for children with severe aplastic anemia: A case series

    Aplastic anemia (AA) is a rare and life-threatening disorder characterized by the presence of hypocellular bone marrow resulting in progressive pancytopenia (low reticulocyte, granulocyte, and platelet count) without dysplasia or bone marrow …

  5. Open Access 01-12-2024 | Aplastic Anemia | Letter

    HERVs may perform as the initial trigger for acquired aplastic anemia

    Current evidence indicates that during the onset of acquired aplastic anemia (AA), the characteristic immune state features an increased number and hyperactivity of CD8 + T lymphocytes [ 1 ]. The reactivation of human endogenous retroviruses …

  6. Open Access 01-12-2024 | Aplastic Anemia | ReviewPaper

    Efficacy and safety of immunosuppressive therapy combined with eltrombopag for severe aplastic anemia: a systematic review and meta-analysis

    Aplastic anemia (AA) is a bone marrow hematopoietic failure syndrome mediated by abnormally activated T cells, which is often clinically manifested as anemia, bleeding, and infection [ 1 , 2 ]. It is classified as severe and non-severe AA according …

  7. 21-03-2024 | Systemic Lupus Erythematosus | ReviewPaper

    Pancytopenia with aplastic anemia in systemic lupus erythematosus: case series and literature review

    Aplastic anemia (AA) is a rare, potentially catastrophic hematopoiesis failure manifested by pancytopenia and bone marrow aplasia. AA occurrence in Systemic Lupus Erythematosus (SLE) patients is extremely rare. The diagnosis may be delayed due to …

  8. 04-04-2024 | Aplastic Anemia | Online First

    Successful Treatment of Severe Aplastic Anemia with Hematopoietic Stem Cell Transplantation in the Setting of Active Mucormycosis

    Severe aplastic anemia (SAA) is a life-threatening hematological disease characterized by the suppression of the bone marrow. Patients with SAA are predisposed to recurrent bacterial infections and invasive fungal infections (IFI) due to profound …

  9. 04-02-2024 | Aplastic Anemia | EditorialNotes

    Aplastic anemia: history and recent developments in diagnosis and treatment

    Acquired aplastic anemia is an immune-mediated disease that targets hematopoietic stem cells, which is diagnosed by findings of peripheral blood pancytopenia and hypocellular bone marrow. Although the diagnostic definition is simple, differential …

  10. 26-02-2024 | Aplastic Anemia | ReviewPaper

    Progress in medical therapy in aplastic anemia: why it took so long?

    The treatment of aplastic anemia (AA) has significantly advanced in the last 50 years, evolving from a fatal condition to one where survival rates now exceed 80–85%. Hematopoietic stem cell transplantation (HSCT) and immunosuppressive therapy …

  11. Open Access 24-01-2024 | Aplastic Anemia | OriginalPaper

    Letermovir Effectively Prevents Cytomegalovirus Infection in Patients with Aplastic Anemia After Hematopoietic Stem Cell Transplantation: A Real-World Retrospective Cohort Study

    Aplastic anemia (AA) is a severe hematopoietic disorder characterized by rapid onset and progression. Currently, the principal intervention for AA is allogeneic hematopoietic stem cell transplantation (allo-HSCT) [ 1 ]. Cytomegalovirus (CMV) is …

  12. 12-12-2023 | Aplastic Anemia | OriginalPaper

    Clinical characteristics of hepatitis-associated aplastic anemia in children

    To understand the current situation of hepatitis-related aplastic anemia (HAAA) in children, we analyzed the patients with HAAA admitted to our hospital in the past 5 years to understand the disease characteristics and prognosis. The clinical data …

  13. 28-12-2022 | Aplastic Anemia | ReviewPaper

    Allogeneic bone marrow transplantation for aplastic anemia

    After more than 60 years of intense research in allogeneic hematopoietic cell transplantation (HCT), this therapy has progressed from one that was fraught with seemingly insurmountable complications to a standard treatment of patients with …

  14. 03-03-2023 | Aplastic Anemia | ReviewPaper

    Recent advances in the diagnosis and treatment of pediatric acquired aplastic anemia

    Acquired aplastic anemia (AA) in children is a rare bone marrow failure that requires several special considerations for its diagnosis and treatment compared with that in adults. The most common issue is the differential diagnosis with refractory …

  15. 20-01-2024 | Paroxysmal Nocturnal Hemoglobinuria | OriginalPaper

    Relapse and transformation to myelodysplastic syndrome and acute myeloid leukemia following immunosuppressive therapy for aplastic anemia is more common as compared to allogeneic stem cell transplantation with a negative impact on survival

    We studied the incidence of relapse, transformation to myelodysplastic syndrome/acute myeloid leukemia, and survival in patients with aplastic anemia (AA) surviving more than 1 year after ATG/ALG-based immunosuppressive therapy (IST) between 1985 …

  16. Open Access 01-12-2023 | Anemia | OriginalPaper

    Experience of life quality from patients with aplastic anemia: a descriptive qualitative study

    Aplastic anemia (AA) is a bone marrow hematopoietic failure syndrome. It is characterized by pancytopenia and bone marrow cell reduction. It clinically manifests as anemia, bleeding, and infection [ 1 ]. Although the pathogenesis of AA has not yet …

  17. 28-09-2023 | Aplastic Anemia | ReviewPaper

    New-onset aplastic anemia after SARS-CoV-2 vaccination

    Aplastic anemia (AA) is a rare autoimmune disease. Drugs, viruses, and radiation are among the most common etiologic factors, and most cases have immune pathophysiology. SARS-CoV-2 vaccines have been linked with rare side effects, including cases …

  18. 26-10-2023 | Aplastic Anemia | OriginalPaper

    Multicenter evaluation of the addition of eltrombopag to immunosuppressive therapy for adults with severe aplastic anemia

    Eltrombopag has been shown to improve response rates when added to standard therapy in adults with severe aplastic anemia in controlled trial settings. However, outcomes in real-world populations have mostly been examined in small retrospective …

  19. 06-12-2023 | Aplastic Anemia | Erratum

    Correction to: Reduced regulatory effects of bone marrow-derived mesenchymal stem cells on activated T lymphocytes and Th1/Th2 cytokine secretion in children with aplastic anemia

  20. Open Access 22-04-2023 | Myelodysplastic Syndrome | OriginalPaper

    Clinical implications of myeloid malignancy‑related somatic mutations in aplastic anemia

    Aplastic anemia (AA) is a potentially fatal bone marrow failure syndrome characterized by a paucity of hematopoietic stem cells and progenitor cells with varying degrees of cytopenia and fatty infiltration of the bone marrow space. Recent advances …

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