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Pain in MS 

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  1. 29-02-2024 | Pain in MS | ReviewPaper

    Pharmacological and Non-pharmacological Approaches for the Management of Neuropathic Pain in Multiple Sclerosis

    Neuropathic pain is a major concern in multiple sclerosis, but treatments have poor efficacy and unpleasant side effects. What options for pain control are available?

  2. 17-02-2024 | Edema | OriginalPaper

    Ameliorative effects of Atriplex crassifolia (C.A.Mey) on pain and inflammation through modulation of inflammatory biomarkers and GC–MS-based metabolite profiling

    Atriplex crassifolia (A. crassifolia) is a locally occurring member of Chenopodiaceae family that has been used in folk medicine for the treatment of joint pain and inflammation. The present study was focused to determine the analgesic and …

  3. Open Access 01-12-2023 | Gout | OriginalPaper

    Ozone alleviates MSU-induced acute gout pain via upregulating AMPK/GAS6/MerTK/SOCS3 signaling pathway

    Gout is characterized by hyperuricemia and recurrent inflammatory episodes caused by intra-articular crystal deposition of monosodium urate (MSU) [ 1 ]. The prevalence of gout has steadily increased due to risk factors such as diet, obesity, and an …

  4. Open Access 01-12-2022 | Back Pain | OriginalPaper

    Construct validity and reliability of the 2-Minute Step Test (2MST) in individuals with low back pain

    Chronic low back pain is a musculoskeletal disorder that generates disability in affected individuals. To understand the clinical aspects, it is necessary to assess pain intensity, quality of life, and disability [ 1 ]. Disability assessment shows …

  5. 03-04-2023 | Diclofenac | OriginalPaper

    UHPLC–MS and GC–MS phytochemical profiling, amelioration of pain and inflammation with chloroform extract of Funaria hygrometrica Hedw. via modulation of inflammatory biomarkers

    People of Pakistan have undisturbed customs for the employment of medicinal plants for healthcare requisites. Chloroform extract of F. hygrometrica (CE FH) was examined for its ability to reduce inflammation and to produce analgesia. Carrageenan …

  6. 12-12-2017 | Online First

    Neuroprotective effects of Moringa oleifera: Bio-guided GC-MS identification of active compounds in diabetic neuropathic pain model

  7. Open Access 01-12-2017 | OriginalPaper

    Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trial

    Participation in group exercise events has risen dramatically over the past twenty years. The number of Americans finishing organized running races has risen from approximately 4.2 million in 1990 to over 15.5 million in 2012 [ 1 ]. The total …

  8. 01-01-2016 | ReviewPaper

    Use of Cannabinoids for Spasticity and Pain Management in MS

    Several randomized trials have demonstrated potential benefit of cannabis derivatives in the symptomatic treatment of multiple sclerosis (MS) patients. These provide class 1 and 2 evidence for cannabinoid product use for spasticity and pain in

  9. Open Access 01-12-2015 | Abstract

    Effects of MSM on exercise-induced muscle and joint pain: a pilot study

    Participants in organized running commonly experience muscle and joint pain while training for and competing in distance events. Many runners report pain as a major influence on changes or breaks in training regimens, and as a common deterrent for …

  10. Open Access 01-06-2012 | Abstract

    P02.187. Schematic body drawings (mSBD) as an outcome measure for CAM interventions in chronic back and neck pain

    Body image may be distorted in chronic back pain patients (Moseley 2008). We thus asked pain patients to complete (by drawing) pre-defined, printed body schematics, which were lacking the outlines of the particular body parts affected (neck and …

  11. Open Access 16-04-2024 | Multiple Sclerosis | Online First

    Clinical trial evidence of quality-of-life effects of disease-modifying therapies for multiple sclerosis: a systematic analysis

    Multiple sclerosis (MS) is a chronic, degenerative, and often progressive disease of the central nervous system that can affect multiple parts of the body and result in various symptoms including mobility restrictions, fatigue, pain, depression …

  12. Open Access 01-12-2020 | Multiple Sclerosis | OriginalPaper

    Neutrophil-selective deletion of Cxcr2 protects against CNS neurodegeneration in a mouse model of multiple sclerosis

    Multiple sclerosis (MS) is a chronic debilitating immune-mediated disease of the central nervous system (CNS) that affects nearly 1 million adults > 18 years of age in the USA [ 1 ]. MS symptoms range from common (e.g., pain, spasms, fatigue [ 2 …

  13. Open Access 01-12-2021 | General Anesthesia | OriginalPaper

    Lidocaine combined with magnesium sulfate preserved hemodynamic stability during general anesthesia without prolonging neuromuscular blockade: a randomized, double-blind, controlled trial

    Anesthetic additive drugs, such as lidocaine and magnesium sulfate (MS), have become increasingly utilized, either alone or in combination, in general anesthesia for postoperative pain reduction, achievement of reduced and more balanced anesthetic …

  14. Open Access 01-12-2024 | OriginalPaper

    Prediction of specific structural damage to the knee joint using qualitative isokinetic analysis

    As a valid and reliable test, isokinetic testing has become one of the gold standards for evaluating knee joint function in clinical practice and scientific research [ 1 ]. Quantitative data in isokinetic testing, such as peak torques, total work …

  15. 17-05-2023 | OriginalPaper

    Nociceptive and Mixed Pain Syndromes in Patients with Multiple Sclerosis

    Nociceptive and mixed pain syndromes (NMPS) pathogenetically associated with focal CNS lesions occur at high frequency in patients with multiple sclerosis (MS). Diverse in localization, symptoms, and mechanisms of development, NMPS significantly …

  16. Open Access 01-12-2024 | Burnout Syndrome | OriginalPaper

    The effect of commuting time on burnout: the mediation effect of musculoskeletal pain

    Burnout is described as physical, emotional, and mental exhaustion resulting from long-term involvement in work situations that are emotionally demanding [ 1 ]. Notably, developing burnout is a multistage process [ 2 ]. In the beginning, people …

  17. 30-01-2024 | Multiple Sclerosis | ReviewPaper

    Brain stimulation for patients with multiple sclerosis: an umbrella review of therapeutic efficacy

    Multiple sclerosis patients often experience various symptoms that can greatly impact their quality of life. There are various brain stimulation techniques that have been evaluated for their ability to reduce the symptoms of multiple sclerosis.

  18. Open Access 23-04-2024 | Fibromyalgia | Online First

    Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review of Observational Studies

    Fibromyalgia syndrome (FMS) is a rheumatic disease (ICD-10 M79.7) of unknown etiology, characterized by chronic widespread pain accompanied by potential neuroinflammation [ 1 ], fatigue, stress [ 2 ], memory loss, sleep disturbance, and multiple …

  19. Open Access 10-05-2024 | Progesterone | Online First

    Sex and disease severity-based analysis of steroid hormones in ME/CFS

    Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disease that primarily manifests as the inability to perform or participate in routine activities that were possible before the onset of the disease [ 1 ].

  20. Open Access 26-04-2024 | Ocrelizumab | Online First

    Dental Adverse Effects of Anti-CD20 Therapies

    Over the past few years, anti-CD20 therapies have seen an increase in interest in the treatment of neurological autoimmune disorders such as multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), or resistant forms of …

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