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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2024

Open Access 01-12-2024 | Neuropathic Pain | Review

Deciphering the functional role of insular cortex stratification in trigeminal neuropathic pain

Authors: Jaisan Islam, Md Taufiqur Rahman, Elina KC, Young Seok Park

Published in: The Journal of Headache and Pain | Issue 1/2024

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Abstract

Trigeminal neuropathic pain (TNP) is a major concern in both dentistry and medicine. The progression from normal to chronic TNP through activation of the insular cortex (IC) is thought to involve several neuroplastic changes in multiple brain regions, resulting in distorted pain perception and associated comorbidities. While the functional changes in the insula are recognized contributors to TNP, the intricate mechanisms underlying the involvement of the insula in TNP processing remain subjects of ongoing investigation. Here, we have overviewed the most recent advancements regarding the functional role of IC in regulating TNP alongside insights into the IC’s connectivity with other brain regions implicated in trigeminal pain pathways. In addition, the review examines diverse modulation strategies that target the different parts of the IC, thereby suggesting novel diagnostic and therapeutic management of chronic TNP in the future.
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Metadata
Title
Deciphering the functional role of insular cortex stratification in trigeminal neuropathic pain
Authors
Jaisan Islam
Md Taufiqur Rahman
Elina KC
Young Seok Park
Publication date
01-12-2024
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 1/2024
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/s10194-024-01784-5

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