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Lymphopenia 

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  1. Open Access 01-12-2024 | Lymphopenia | OriginalPaper

    Clinical impact of transient lymphopenia

    Transient or persistent immunosuppression is a known risk factor for morbidity and mortality in critically ill patients. Aim of the present study is to evaluate the lymphopenia in patients admitted to the Emergency Unit of AOU Policlinico Umberto …

  2. 27-12-2023 | Dimethyl Fumarate | OriginalPaper

    Bariatric surgery and dimethyl fumarate-induced lymphopenia in patients with multiple sclerosis

    Dimethyl fumarate (DMF) is an oral disease-modifying therapy (DMT) for relapsing multiple sclerosis (R-MS). The phase III clinical trials demonstrated a favorable safety profile [ 1 , 2 ]. However, 5% of patients with MS (pwMS) in the phase 3 trial …

  3. Open Access 01-12-2024 | Lymphopenia | OriginalPaper

    Systematic review and pooled analysis of the impact of treatment-induced lymphopenia on survival of glioblastoma patients

    Survival rates for glioblastoma remain poor despite advances in treatments that have iteratively extended survival times. The current standard of care involves maximal safe resection in combination with chemotherapy and radiation therapy (RT) …

  4. 01-04-2024 | Neonatal Screening | OriginalPaper

    Newborn Screening for Severe T and B Cell Lymphopenia Using TREC/KREC Detection: A Large-Scale Pilot Study of 202,908 Newborns

    Newborn screening (NBS) for severe inborn errors of immunity (IEI), affecting T lymphocytes, and implementing measurements of T cell receptor excision circles (TREC) has been shown to be effective in early diagnosis and improved prognosis of …

  5. Open Access 04-01-2024 | Lymphopenia | BriefCommunication

    ASO Author Reflections: Perioperative Lymphopenia Following Hepatectomy for Hepatocellular Carcinoma: A Routine Yet Overlooked Prognostic Biomarker

    Immune dysregulation plays an important role in cancer progression. 1 , 2 Lymphopenia, defined as the absence or reduced count of host lymphocytes, in the perioperative period might indicate a state of pre-existing cancer-related immune tolerance.

  6. 05-01-2024 | Lymphopenia | OriginalPaper

    Perioperative Lymphopenia is Associated with Increased Risk of Recurrence and Worse Survival Following Hepatectomy for Hepatocellular Carcinoma

  7. Open Access 01-12-2023 | Lymphopenia | OriginalPaper

    Pooled prevalence of lymphopenia in all-cause hospitalisations and association with infection: a systematic review and meta-analysis

    Immune dysfunction plays a central role in a wide range of diseases including cancer, atherosclerosis, trauma, and infections [ 1 – 4 ]. In the context of sepsis, this dysfunction is demonstrated across innate and adaptive immunity, and is …

  8. 15-06-2023 | Lymphopenia | OriginalPaper

    Zoledronic acid–induced severe lymphopenia

    Although anemia, thrombocytopenia, and mild lymphopenia have been reported in the acute phase response after zoledronic acid, severe lymphopenia has not been reported. This article describes a case of severe lymphopenia following a 5 mg zoledronic …

  9. Open Access 01-12-2023 | Lymphopenia | OriginalPaper

    Lymphocyte recovery from radiation-induced lymphopenia in locally advanced esophageal squamous cell carcinoma: correlations with prognosis and lymphocyte-related organs

    Radiotherapy as a recognized anti-tumor approach, is a double-edged sword as it also leads to the depletion of immune cells [ 1 , 2 ]. Lymphocytes as vital immune cells in response to immunotherapy [ 3 ], are quite radiosensitive, being easily …

  10. 23-12-2022 | Lymphopenia | OriginalPaper

    Impact of lymphopenia on efficacy of nivolumab in head and neck cancer patients

    HNSCC is the 4 th most common cancer in France with an incidence of 17,000 new cases per year [ 1 ]. Of localized HNSCC patients, 50% experience locoregional recurrences [ 2 ] and 15% have metastatic evolutions [ 3 ]. As in other solid cancers [ 4 …

  11. Open Access 01-12-2022 | NSCLC | OriginalPaper

    Prognostic value of CD4+ T lymphopenia in non-small cell lung Cancer

    Recent progress in the treatment of non-small cell lung cancer (NSCLC) includes the introduction of immunotherapy, especially immune checkpoint inhibitors [ 1 ]. Although the use of immunotherapy in NSCLC has shown promising results, there remains …

  12. 20-04-2023 | Lymphopenia | ReviewPaper

    Impact of Age on Poly(ADP-Ribose) Polymerase Inhibitor (PARPi)-Induced Lymphopenia: A Scoping Review of the Literature and Internal Analysis of a Retrospective Database

    The poly(ADP-ribose) polymerase (PARP) superfamily of enzymes is involved in the synthesis of ADP-ribose polymers [ 1 ], which can be further processed and bound to damaged DNA [ 2 , 3 ] to enable recruitment of DNA repair effectors. The practical …

  13. Open Access 01-12-2022 | Septicemia | OriginalPaper

    High prevalence of infections in non-COVID-19 patients admitted to the Emergency Department with severe lymphopenia

    Infection is one of the most frequent reasons for admission to the Emergency Department (ED), with an overall mortality which still approximates 15% [ 1 ]. Early and accurate recognition of infections is therefore crucial to improve prognosis [ 2 …3

  14. 19-07-2023 | Uveitis | OriginalPaper

    Diagnostic efficacy of elevated serum angiotensin-converting enzyme and lymphopenia between presumed sarcoid uveitis and presumed tubercular uveitis

    Sarcoidosis is a multisystem inflammatory disorder with unknown aetiology, affecting many organs including the eye and characterised by non-caseating granulomas [ 1 – 3 ]. It causes a sight-threatening intraocular inflammation. It is a major …

  15. 04-07-2023 | Lymphopenia | Letter

    Late-Onset Lymphopenia and ITP in a Patient with Hyper IgM Syndrome Due to a Homozygous Variant in AICDA

  16. 01-05-2022 | Glioblastoma

    Association between treatment-related lymphopenia and survival in glioblastoma patients following postoperative chemoradiotherapy

    Radiation-induced lymphopenia has been associated with poor survival in several solid tumors such as, esophageal [ 1 ], lung [ 2 – 4 ], pancreatic [ 5 ] and cervical cancers [ 6 , 7 ]. Lymphocytes are among the most radiosensitive cells in the body …

  17. 25-01-2023 | Pneumococcus | OriginalPaper

    Impact of severe lymphopenia on the early prediction of clinical outcome in hospitalized patients with pneumococcal community-acquired pneumonia

    Community-acquired pneumonia (CAP) remains one of the leading causes of hospitalization and places a burden on healthcare systems worldwide [ 1 , 2 ] . It is currently the most common infectious cause of death in the developed world despite …

  18. 01-03-2022 | Lymphopenia | OriginalPaper

    Prognostic impact of neutrophilia and lymphopenia on survival in anal cancer treated with definitive concurrent chemoradiotherapy: a retrospective multicenter study

    Anal cancer is a rare malignancy which accounts for approximately 0.1% of the cancer incidence in Korea [ 1 ]. Squamous cell carcinoma is the most common type of anal cancer, and generally develops after human papillomavirus (HPV) infection in …

  19. 01-10-2021 | Herpes Virus

    Alternative Approach to Varicella Zoster Virus Prevention in a Child with Lymphopenia

  20. Open Access 01-12-2021 | Lymphopenia | OriginalPaper

    Vertebral body and splenic irradiation are associated with lymphopenia in localized pancreatic cancer treated with stereotactic body radiation therapy

    Pancreatic cancer is currently the third most common cause of cancer related deaths in the United States, responsible for over 48,000 deaths each year [ 1 ]. By the year 2030, it is expected to be the second most common cause of cancer related …

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