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Growth Factors 

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  1. Open Access 01-12-2024 | Growth Factors | OriginalPaper

    EGF-like growth factors upregulate pentraxin 3 expression in human granulosa-lutein cells

    The epidermal growth factor (EGF)-like factors, comprising amphiregulin (AREG), betacellulin (BTC), and epiregulin (EREG), play a critical role in regulating the ovulatory process. Pentraxin 3 (PTX3), an essential ovulatory protein, is necessary …

  2. Open Access 01-12-2024 | Edema | OriginalPaper

    Association between the response of intravitreal antivascular endothelial growth factor injection and systemic factors of diabetic macular edema

    Diabetic retinopathy is the most common cause of vision loss in patients with diabetes > 20 years. In chronic hyperglycemia, microvascular abnormalities and obstructions cause diabetic macular edema, which is the main cause of permanent vision loss …

  3. Open Access 01-12-2024 | Breast Cancer | OriginalPaper

    Neuropilin-1 and placental growth factor as prognostic factors in metastatic breast cancer

    The vascular endothelial growth factor (VEGF) family plays a crucial role in tumor angiogenesis and, thus, in both tumor progression and metastasizing. The VEGF family contains the factors VEGF-A, VEGF-B, VEGF-C, and VEGF-D, placental growth

  4. Open Access 12-12-2023 | Kidney Cancer | OriginalPaper

    Transforming growth factors β and their signaling pathway in renal cell carcinoma and peritumoral space—transcriptome analysis

    Transforming growth factor β1 (TGFβ1) is a protein that regulates cell proliferation, growth, differentiation, and movement. It acts as an apoptosis regulator in normal and pathologically altered tissues, and thus controls the balance between …

  5. Open Access 01-12-2024 | Growth Factors | OriginalPaper

    Exosomal-miRNas expression and growth factors released by mononuclear cells of CLAD patients in response to extracorporeal photopheresis

    The long-term outcome of lung transplantation is significantly affected by the occurrence of chronic lung allograft dysfunction (CLAD). CLAD and its two main phenotypes, bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome …

  6. Open Access 01-12-2024 | Breast Cancer | OriginalPaper

    Association of hormone receptors and human epidermal growth factor receptor-2/neu expressions with clinicopathologic factors of breast carcinoma: a cross-sectional study in a tertiary care hospital, Kabul, Afghanistan

    Breast cancer (BC) is the most common malignancy affecting women globally [ 1 ]. According to the World Health Organization’s (WHO) estimation in 2020, BC had the highest prevalence rate of 2.3 million cases (11.7%), resulting in 6.9% deaths. BC is …

  7. 01-09-2023 | Growth Factors | OriginalPaper

    Current Data on the Age-Related Macular Degeneration Pathophysiology: Focus on Growth Factors and Neurotrophins

    Age-related macular degeneration (AMD) is a complex multifactorial disease resulting from dysfunction and degeneration of the retinal pigment epithelium (RPE), choriocapillaris, and photoreceptor loss. The exact mechanism of pathogenesis is …

  8. Open Access 07-09-2023 | Osteosarcoma | OriginalPaper

    Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization

    Survival in osteosarcoma, the most common primary tumor of bone, hinges almost entirely on the presence or absence of metastasis. More than 80% of osteosarcoma patients that develop metastasis die within five years, compared to 30% of patients …

  9. 01-10-2023 | Letter

    Confounding Factors Influencing Growth

  10. Open Access 01-12-2023 | Knee Osteoarthritis | OriginalPaper

    Restoring Study PRGF: a randomized clinical trial on plasma rich in growth factors for knee osteoarthritis

    There is substantial concern within the scientific community about the profusion of incompletely reported and misreported studies. Projects such as the Restoring Invisible & Abandoned Trials (RIAT) initiative ( https://restoringtrials.org ), which …

  11. 01-04-2023 | Acute Myeloid Leukemia | News

    Antineoplastics/unspecified growth-factors/unspecified granulocyte-colony-stimulating-factors

    Various toxicities and lack of efficacy: case report
  12. Open Access 01-12-2023 | Systemic Lupus Erythematosus | OriginalPaper

    Immunoprofiling of cytokines, chemokines, and growth factors in female patients with systemic lupus erythematosus– a pilot study

    Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease affecting different organ systems. This study aimed to determine the concentrations of 30 different human cytokines, chemokines, and growth factors in human plasma to understand …

  13. Open Access 01-12-2023 | Painful Arc | OriginalPaper

    Effectiveness of lyophilized growth factors injection for subacromial impingement syndrome: a prospective randomized double-blind placebo-controlled study

    Shoulder pain is the third leading musculoskeletal complaint with subacromial impingement syndrome (SIS), accounting for 44–65% of all shoulder complaints, resulting in functional limitation and disability [ 1 – 4 ].

  14. Open Access 01-12-2023 | Bevacizumab | OriginalPaper

    Risk of retinal vein occlusion in colorectal cancer patients receiving anti-vascular endothelial growth factors – a population-based cohort study

    Colorectal cancer (CRC) is a disease of high prevalence, with an annual incidence over 1.8 million newly diagnosed cases and an annual mortality of almost 700,000 deaths [ 1 ]. It is the 3 rd most commonly diagnosed cancer worldwide. Although the …

  15. Open Access 01-12-2023 | Growth Factors | OriginalPaper

    Fibrin clot and Leukocyte-rich platelet-rich fibrin show similar release kinetics and amount of growth factors: a pilot study

    The meniscus primarily functions to efficiently transmit load through the femoro-tibial joint and provides chondral protection for the femoral and tibial joint surfaces [ 1 ]. Therefore, injury or resection of the meniscus causes increase in …

  16. Open Access 01-12-2022 | Growth Factors | OriginalPaper

    Plasma rich in growth factors (PRGF) and leukocyte-platelet rich fibrin (L-PRF): comparative release of growth factors and biological effect on osteoblasts

    Autologous platelet concentrates (APCs) are used as surgical adjuvants to improve wound healing and tissue regeneration. There are many preparation protocols which result in different end products [ 1 ], but the underlying biological mechanism is …

  17. 07-07-2023 | Chronic Pancreatitis | Report

    Differential location of growth factors and pancreatic stellate cell activation in chronic pancreatitis

    Pancreatic fibrosis is characterized by the activation of pancreatic stellate cells leading to the expression of smooth muscle actin (α-SMA). Normal pancreatic tissue has predominantly quiescent stellate cells in periductal and perivascular …

  18. 14-08-2023 | Aesthetic-Plastic Surgery | Online First

    A Comprehensive Review of Concentrated Growth Factors and Their Novel Applications in Facial Reconstructive and Regenerative Medicine

  19. 28-06-2023 | Diabetic Retinopathy | OriginalPaper

    Evaluation of the efficacy of anti-vascular endothelial growth factors in diabetic macular edema with retinal inner and outer layers disorganization

    Diabetes mellitus (DM) is a global epidemic with severe complications [ 1 ]. According to the report published by the International Diabetes Federation in 2013, it was determined that there are 382 million DM patients worldwide, and this number is …

  20. Open Access 01-12-2023 | Knee Osteoarthritis | OriginalPaper

    Cost-utility analysis and net monetary benefit of Platelet Rich Plasma (PRP), intra-articular injections in compared to Plasma Rich in Growth Factors (PRGF), Hyaluronic Acid (HA) and ozone in knee osteoarthritis in Iran

    Osteoarthritis (OA), which is considered one of the leading causes of disability, is a chronic, progressive, and the most common form of joint disorder. Pain, crepitation, stiffness, and decreased range of motion in involved joints, especially …

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