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01-01-2022 | Statins | Original Article

Predictors of the effectiveness of insulin pumps in patients with type 1 diabetes mellitus

Authors: Joana Camões Neves, João Sérgio Neves, Celestino Neves, Davide Carvalho

Published in: Endocrine | Issue 1/2022

Abstract

Purpose

Insulin pump therapy has become the preferential treatment for type 1 diabetes (T1D) as it mimics the physiological secretion of insulin better than multiple daily injections. However, not all patients improve with insulin pump therapy. This study aims to determine the predictors of the effectiveness of insulin pumps in T1D.

Methods

We conducted a retrospective observational study of patients who started insulin pumps. Data from four timepoints (before, at 6, 12, and 36 months) were evaluated for outcomes of glycemic control and safety. The association of baseline predictors with outcomes was analyzed using linear and logistic regression models.

Results

We evaluated 136 patients (57.4% females, age 36 ± 12 years, duration of T1D 14 ± 9 years). During the follow-up, there was a mean decrease of HbA1c of 0.9 ± 1.2%. The improvement in HbA1c was independent of sex, age, and duration of T1D. Higher baseline HbA1c, family history of diabetes, and not being treated with statins were predictors of improvement in HbA1c. Not being treated with statins and higher baseline HbA1c predicted improvement in HbA1c without worsening hypoglycemia. History of hypoglycemia was a predictor of severe hypoglycemia. Family history, higher baseline HbA1c, and psychological/psychiatric disorders were predictors of ketoacidosis.

Conclusion

Benefits of insulin pump were independent of sex, age, and duration of T1D. Baseline HbA1c, family history of diabetes, treatment with statins, history of hypoglycemia, and psychological/psychiatric disorders were predictors of outcomes, and may allow the identification of patients who benefit most from insulin pump therapy or who are at increased risk of complications.

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Title: Predictors of the effectiveness of insulin pumps in patients with type 1 diabetes mellitus
Authors: Joana Camões Neves
João Sérgio Neves
Celestino Neves
Davide Carvalho
Publication date: 01-01-2022
Publisher: Springer US
Keywords: Statins
Insulins
Ketoacidosis
Hypoglycemia
Diabetes
Insulins
Type 1 Diabetes
Published in: Endocrine / Issue 1/2022
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-021-02837-4

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