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European Journal of Drug Metabolism and Pharmacokinetics

Issue 3/2016

Content (13 Articles)

Original Paper

Initial dosing regimen of vancomycin to achieve early therapeutic plasma concentration in critically ill patients with MRSA infection based on APACHE II score

Masaharu Imaura, Haruko Yokoyama, Yuji Kohata, Riichiro Kanai, Tomoki Kohyama, Wataru Idemitsu, Yuichi Maki, Takashi Igarashi, Hiroyuki Takahashi, Hiroshi Kanno, Yasuhiko Yamada

Original Paper

Pharmacokinetic and biodistribution study of eserine and pralidoxime chloride in rabbits following a single application of a transdermal patch

Subham Banerjee, Pronobesh Chattopadhyay, Animesh Ghosh, Aseem Bhatnagar, Vijay Veer

Original Paper

A comparison of the pharmacokinetics of three different preparations of total flavones of Hippophae rhamnoides in beagle dogs after oral administration

Jingze Duan, Yang Dang, Houjun Meng, Huizhen Wang, Ping Ma, Guowen Li, Tao Wu, Yan Xie

Original Paper

Efflux and uptake transporters involved in the disposition of bazedoxifene

Tina Trdan Lušin, Aleš Mrhar, Bruno Stieger, Albin Kristl, Katja Berginc, Jurij Trontelj

Open Access Original Paper

Comparison of pharmacokinetic and safety profiles between Bemfola® and Gonal-f® after subcutaneous application

Michael Wolzt, Ghazeleh Gouya, Michael Sator, Thomas Hemetsberger, Charlotte Irps, Manfred Rettenbacher, Brigitta Vcelar

Original Paper

The CYP4502D6 *4 and *6 alleles are the molecular genetic markers for drug response: implications in colchicine non-responder FMF patients

Sinem Yalcıntepe, Ozturk Ozdemır, Coskun Sılan, Filiz Ozen, Ahmet Uludag, Ferhan Candan, Fatma Sılan

Original Paper

Preparation, characterization and pharmacokinetics evaluation of clarithromycin-loaded Eudragit® L-100 microspheres

Jinghua Xu, Wei Li, Zhuo Liu, Jinghan Li, Xiaoyun Zhao, DongYang Li, Shuang Guo, Xiangrong Zhang

Original Paper

Absorption, elimination and cerebrospinal fluid concentrations of nimodipine in healthy beagle dogs receiving human intravenous and oral formulation

Janne Koskimäki, Miikka Tarkia, Tuula Ahtola-Sätilä, Lasse Saloranta, Aki Laakso, Janek Frantzén

Original Paper

Effects of dose, flow rate, and bile acid on diclofenac disposition in the perfused rat liver

Misato Uraki, Atsushi Kawase, Yuka Matsushima, Masahiro Iwaki

Original Paper

Sunitinib tissue distribution changes after coadministration with ketoconazole in mice

Evelyn Li-Ching Chee, Adeline Yi Ling Lim, Pilar Modamio, Cecilia Fernandez-Lastra, Ignacio Segarra