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European Journal of Drug Metabolism and Pharmacokinetics

Published in:

01-06-2016 | Original Paper

A comparison of the pharmacokinetics of three different preparations of total flavones of Hippophae rhamnoides in beagle dogs after oral administration

Authors: Jingze Duan, Yang Dang, Houjun Meng, Huizhen Wang, Ping Ma, Guowen Li, Tao Wu, Yan Xie

Published in: European Journal of Drug Metabolism and Pharmacokinetics | Issue 3/2016

Abstract

Pharmacokinetic properties of isorhamnetin, quercetin, and kaempferol in three different total flavones of Hippophae rhamnoides (TFH) preparations were compared after oral administration to beagle dogs by a UPLC–MS method. The pharmacokinetic results showed that C _max of isorhamnetin and quercetin in TFH solid dispersion (TFH-SD) and TFH self-emulsifying (TFH-SE) preparations was significantly enhanced than that in TFH preparations (p < 0.05). The AUCs of isorhamnetin and quercetin in TFH-SD were 5.9- and 3.1-fold higher than that of TFH, while the AUCs of isorhamnetin and quercetin in TFH-SE were 3.4- and 2.4-fold higher than that of TFH. These findings suggested that the oral bioavailability of isorhamnetin and quercetin in beagle dogs can be significantly increased in TFH-SD and TFH-SE preparations compared to TFH preparations, which was helpful to explore the new forms for oral administration TFH and explain their in vivo processes.

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Title: A comparison of the pharmacokinetics of three different preparations of total flavones of Hippophae rhamnoides in beagle dogs after oral administration
Authors: Jingze Duan
Yang Dang
Houjun Meng
Huizhen Wang
Ping Ma
Guowen Li
Tao Wu
Yan Xie
Publication date: 01-06-2016
Publisher: Springer International Publishing
Published in: European Journal of Drug Metabolism and Pharmacokinetics / Issue 3/2016
Print ISSN: 0378-7966
Electronic ISSN: 2107-0180
DOI: https://doi.org/10.1007/s13318-015-0254-9

At a glance: The STEP trials

Springer Medicine

A comparison of the pharmacokinetics of three different preparations of total flavones of Hippophae rhamnoides in beagle dogs after oral administration

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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