Issue 1/2024
Content (10 Articles)
Patients with Obesity Should be Recognised as a Special Patient Population During Drug Development of Antibacterial and Antifungal Agents; A Call to Action
K. P. van Rhee, C. A. J. Knibbe, P. D. van der Linden, R. J. M. Brüggemann
A Comprehensive Review of the Clinical Pharmacokinetics, Pharmacodynamics, and Drug Interactions of Nirmatrelvir/Ritonavir
Jacqueline Gerhart, Donna S. Cox, Ravi Shankar P. Singh, Phylinda L. S. Chan, Rohit Rao, Richard Allen, Haihong Shi, Joanna C. Masters, Bharat Damle
Interplay of UDP-Glucuronosyltransferase and CYP2C8 for CYP2C8 Mediated Drug Oxidation and Its Impact on Drug–Drug Interaction Produced by Standardized CYP2C8 Inhibitors, Clopidogrel and Gemfibrozil
Katsumi Iga, Akiko Kiriyama
Pharmacokinetics, Safety, and Tolerability of Anti-SARS-CoV-2 Monoclonal Antibody, Sotrovimab, Delivered Intravenously or Intramuscularly in Japanese and Caucasian Healthy Volunteers
Ahmed Nader, Elizabeth Alexander, Dimitra Brintziki, Amina Z. Haggag, Stephen A. Harrison, Ian A. Hawes, Marjan Hezareh, Andrew M. Lippa, Arisa Okamasa, Malek Okour, Nobuhiko Okuda, Jennifer E. Sager, Scott Segal, Yuri Shida, Andrew Skingsley, Robert Williams, Esther Y. Yoon, Daren Austin
Development of a Generic Fetal Physiologically Based Pharmacokinetic Model and Prediction of Human Maternal and Fetal Organ Concentrations of Cefuroxime
Xiaomei I. Liu, Dionna J. Green, John van den Anker, Homa K. Ahmadzia, Gilbert J. Burckart, André Dallmann
How to Dose Vancomycin in Overweight and Obese Patients with Varying Renal (Dys)function in the Novel Era of AUC 400–600 mg·h/L-Targeted Dosing
Tan Zhang, Elke H. J. Krekels, Cornelis Smit, Eric P. A. van Dongen, Roger J. M. Brüggemann, Catherijne A. J. Knibbe
Population Pharmacokinetic/Pharmacodynamic Analysis of the Glucokinase Activator PB201 in Healthy Volunteers and Patients with Type 2 Diabetes Mellitus: Facilitating the Clinical Development of PB201 in China
Ling Song, Fangrui Cao, Shu Niu, Michael Xu, Ruifang Liang, Ke Ding, Zhigang Lin, Xueting Yao, Dongyang Liu
Digoxin Pharmacokinetics in Patients with Obesity Before and After a Gastric Bypass or a Strict Diet Compared with Normal Weight Individuals
Kine Eide Kvitne, Markus Hovd, Line Kristin Johnson, Christine Wegler, Cecilia Karlsson, Per Artursson, Shalini Andersson, Rune Sandbu, Jøran Hjelmesæth, Eva Skovlund, Rasmus Jansson-Löfmark, Hege Christensen, Anders Åsberg, Ida Robertsen
Impact of Key Components of Intensified Ceftaroline Dosing on Pharmacokinetic/Pharmacodynamic Target Attainment
Iris K. Minichmayr, Sebastian G. Wicha, Peter Matzneller, Charlotte Kloft, Markus Zeitlinger