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Cardiovascular Diabetology

Issue 1/2016

Content (164 Articles)

Open Access Original investigation

Circulating angiopoietin-like protein 8 (ANGPTL8) and ANGPTL3 concentrations in relation to anthropometric and metabolic profiles in Korean children: a prospective cohort study

Hye Soo Chung, Min Jung Lee, Soon Young Hwang, Hyun Jung Lee, Hye Jin Yoo, Ji-A Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Dong Seop Choi, Seon Mi Kim, Kyung Mook Choi

Open Access Original investigation

Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function

Chang-Chiang Chen, Hendra Susanto, Wen-Han Chuang, Ta-Yu Liu, Chih-Hong Wang

Open Access Original investigation

CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial

Dolores Corella, Eva. M. Asensio, Oscar Coltell, José V. Sorlí, Ramón Estruch, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Olga Castañer, Fernando Arós, José Lapetra, Lluís Serra-Majem, Enrique Gómez-Gracia, Carolina Ortega-Azorín, Miquel Fiol, Javier Díez Espino, Andrés Díaz-López, Montserrat Fitó, Emilio Ros, José M. Ordovás

Open Access Original investigation

Lower-extremity amputation as a marker for renal and cardiovascular events and mortality in patients with long standing type 1 diabetes

Kamel Mohammedi, Louis Potier, Narimène Belhatem, Nadia Matallah, Samy Hadjadj, Ronan Roussel, Michel Marre, Gilberto Velho

Open Access Original investigation

Reduction of CTRP9, a novel anti-platelet adipokine, contributes to abnormal platelet activity in diabetic animals

Wenqing Wang, Wayne Bond Lau, Yajing Wang, Xinliang Ma, Rong Li

Open Access Original investigation

Effects of analogue insulin in multiple daily injection therapy of type 2 diabetes on postprandial glucose control and cardiac function compared to human insulin: a randomized controlled long-term study

Helene von Bibra, Thorsten Siegmund, Iris Kingreen, Markus Riemer, Tibor Schuster, Petra-Maria Schumm-Draeger

Open Access Original investigation

Urinary alpha-1 antitrypsin and CD59 glycoprotein predict albuminuria development in hypertensive patients under chronic renin-angiotensin system suppression

Laura Gonzalez-Calero, Marta Martin-Lorenzo, Fernando de la Cuesta, Aroa S. Maroto, Montserrat Baldan-Martin, Gema Ruiz-Hurtado, Helena Pulido-Olmo, Julian Segura, Maria G. Barderas, Luis M. Ruilope, Fernando Vivanco, Gloria Alvarez-Llamas

Open Access Original Investigation

The ratio of skeletal muscle mass to visceral fat area is a main determinant linking circulating irisin to metabolic phenotype

You-Cheol Hwang, Won Seon Jeon, Cheol-Young Park, Byung-Soo Youn

Open Access Original investigation

Is visceral adiposity a modifier for the impact of blood pressure on arterial stiffness and albuminuria in patients with type 2 diabetes?

Ryotaro Bouchi, Norihiko Ohara, Masahiro Asakawa, Yujiro Nakano, Takato Takeuchi, Masanori Murakami, Yuriko Sasahara, Mitsuyuki Numasawa, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa

Open Access Original investigation

Bezafibrate for the treatment of dyslipidemia in patients with coronary artery disease: 20-year mortality follow-up of the BIP randomized control trial

Yaron Arbel, Robert Klempfner, Aharon Erez, Ilan Goldenberg, Sagit Benzekry, Nir Shlomo, Enrique Z. Fisman, Alexander Tenenbaum

Open Access Original investigation

Apolipoprotein E gene polymorphism and risk of type 2 diabetes and cardiovascular disease

Dalia El-Lebedy, Hala M. Raslan, Asmaa M. Mohammed

Open Access Original investigation

Effects of exercise training on carotid intima-media thickness in patients with type 2 diabetes and coronary artery disease. Influence of carotid plaques

Rune Byrkjeland, Knut-Haakon Stensæth, Sigmund Anderssen, Ida U. Njerve, Harald Arnesen, Ingebjørg Seljeflot, Svein Solheim

Open Access Original investigation

Cardiovascular disease guideline adherence and self-reported statin use in longstanding type 1 diabetes: results from the Canadian study of longevity in diabetes cohort

Johnny W. Bai, Geneviève Boulet, Elise M. Halpern, Leif E. Lovblom, Devrim Eldelekli, Hillary A. Keenan, Michael Brent, Narinder Paul, Vera Bril, David Z. I. Cherney, Alanna Weisman, Bruce A. Perkins

Open Access Original investigation

Early cardiovascular events in women with a history of gestational diabetes mellitus

Karine Goueslard, Jonathan Cottenet, Anne-Sophie Mariet, Maurice Giroud, Yves Cottin, Jean-Michel Petit, Catherine Quantin

Open Access Original investigation

Impact of metabolic syndrome and its components on heart rate variability during hemodialysis: a cross-sectional study

Yu-Ming Chang, Chih-Chung Shiao, Ya-Ting Huang, I-Ling Chen, Chuan-Lan Yang, Show-Chin Leu, Hung-Li Su, Jsun-Liang Kao, Shih-Ching Tsai, Rong-Na Jhen, Ching-Cherng Uen

Open Access Original Investigation

Evidence of a causal relationship between high serum adiponectin levels and increased cardiovascular mortality rate in patients with type 2 diabetes

Lorena Ortega Moreno, Massimiliano Copetti, Andrea Fontana, Concetta De Bonis, Lucia Salvemini, Vincenzo Trischitta, Claudia Menzaghi

Open Access Original investigation

High glucose-induced hyperosmolarity contributes to COX-2 expression and angiogenesis: implications for diabetic retinopathy

Rosalinda Madonna, Gaia Giovannelli, Pamela Confalone, Francesca Vera Renna, Yong-Jian Geng, Raffaele De Caterina

Open Access Original investigation

Polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating proprotein convertase subtilisin/kexin type 9 (PCSK9)

Yu Wang, Jiantao Ye, Jie Li, Cheng Chen, Junying Huang, Peiqing Liu, Heqing Huang

Open Access Original investigation

Evaluation of pleiotropic effects among common genetic loci identified for cardio-metabolic traits in a Korean population

Yun Kyoung Kim, Mi Yeong Hwang, Young Jin Kim, Sanghoon Moon, Sohee Han, Bong-Jo Kim

Open Access Original Investigation

Interleukin-6 predicts inflammation-induced increase of Glucagon-like peptide-1 in humans in response to cardiac surgery with association to parameters of glucose metabolism

Corinna Lebherz, Florian Kahles, Katja Piotrowski, Michael Vogeser, Ann Christina Foldenauer, Kirsten Nassau, Erich Kilger, Nikolaus Marx, Klaus G. Parhofer, Michael Lehrke

Open Access Original investigation

Incremental prognostic value of global longitudinal strain in patients with type 2 diabetes mellitus

Ju-Hua Liu, Yan Chen, Michele Yuen, Zhe Zhen, Carmen Wing-Sze Chan, Karen Siu-Ling Lam, Hung-Fat Tse, Kai-Hang Yiu

Open Access Original investigation

Low circulating pentraxin 3 levels in pregnancy is associated with gestational diabetes and increased apoB/apoA ratio: a 5-year follow-up study

Tove Lekva, Annika Elisabeth Michelsen, Jens Bollerslev, Errol R. Norwitz, Pål Aukrust, Tore Henriksen, Thor Ueland

Open Access Original investigation

Telmisartan in the diabetic murine model of acute myocardial infarction: dual contrast manganese-enhanced and delayed enhancement MRI evaluation of the peri-infarct region

Ildiko Toma, Paul J. Kim, Rajesh Dash, Michael V. McConnell, Dwight Nishimura, Phillip Harnish, Phillip C. Yang

Open Access Original investigation

Circulating angiopoietin-like protein 8 (betatrophin) association with HsCRP and metabolic syndrome

Mohamed Abu-Farha, Jehad Abubaker, Irina Al-Khairi, Preethi Cherian, Fiona Noronha, Sina Kavalakatt, Abdelkrim Khadir, Kazem Behbehani, Monira Alarouj, Abdullah Bennakhi, Naser Elkum

Open Access Original investigation

Type 2 diabetes enhances arterial uptake of choline in atherosclerotic mice: an imaging study with positron emission tomography tracer 18F-fluoromethylcholine

Sanna Hellberg, Johanna M. U. Silvola, Max Kiugel, Heidi Liljenbäck, Olli Metsälä, Tapio Viljanen, Jari Metso, Matti Jauhiainen, Pekka Saukko, Pirjo Nuutila, Seppo Ylä-Herttuala, Juhani Knuuti, Anne Roivainen, Antti Saraste

Open Access Original investigation

Metformin improves the angiogenic potential of human CD34+ cells co-incident with downregulating CXCL10 and TIMP1 gene expression and increasing VEGFA under hyperglycemia and hypoxia within a therapeutic window for myocardial infarction

Sherin Bakhashab, Fahad W. Ahmed, Hans-Juergen Schulten, Ayat Bashir, Sajjad Karim, Abdulrahman L. Al-Malki, Mamdooh A. Gari, Adel M. Abuzenadah, Adeel G. Chaudhary, Mohammed H. Alqahtani, Sahira Lary, Farid Ahmed, Jolanta U. Weaver

Open Access Original investigation

Use of imaging and clinical data to screen for cardiovascular disease in asymptomatic diabetics

Carlos Henrique Reis Esselin Rassi, Timothy W. Churchill, Carlos A. Fernandes Tavares, Mateus Guimaraes Fahel, Fabricia P. O. Rassi, Augusto H. Uchida, Bernardo L. Wajchenberg, Antonio C. Lerario, Edward Hulten, Khurram Nasir, Márcio S. Bittencourt, Carlos Eduardo Rochitte, Ron Blankstein

Open Access Original Investigation

LEADER 5: prevalence and cardiometabolic impact of obesity in cardiovascular high-risk patients with type 2 diabetes mellitus: baseline global data from the LEADER trial

L. Masmiquel, L. A. Leiter, J. Vidal, S. Bain, J. Petrie, E. Franek, I. Raz, A. Comlekci, S. Jacob, L. van Gaal, F. M. M. Baeres, S. P. Marso, M. Eriksson

Open Access Original investigation

Skin collagen fluorophore LW-1 versus skin fluorescence as markers for the long-term progression of subclinical macrovascular disease in type 1 diabetes

David R. Sell, Wanjie Sun, Xiaoyu Gao, Christopher Strauch, John M. Lachin, Patricia A. Cleary, Saul Genuth, Vincent M. Monnier

Open Access Original Investigation

Early changes in cardiovascular structure and function in adolescents with type 1 diabetes

Timothy J. Bradley, Cameron Slorach, Farid H. Mahmud, David B. Dunger, John Deanfield, Livia Deda, Yesmino Elia, Ronnie L. H. Har, Wei Hui, Rahim Moineddin, Heather N. Reich, James W. Scholey, Luc Mertens, Etienne Sochett, David Z. I. Cherney

Open Access Original investigation

Upregulation of inducible NO synthase by exogenous adenosine in vascular smooth muscle cells activated by inflammatory stimuli in experimental diabetes

Alberto Nassi, Francesca Malorgio, Serena Tedesco, Andrea Cignarella, Rosa Maria Gaion

Open Access Commentary

Report from the 1st Cardiovascular Outcome Trial (CVOT) Summit of the Diabetes & Cardiovascular Disease (D&CVD) EASD Study Group

Oliver Schnell, Eberhard Standl, Doina Catrinoiu, Stefano Genovese, Nebojsa Lalic, Jan Skra, Paul Valensi, Antonio Ceriello

Open Access Original investigation

Diabetes is an independent predictor of right ventricular dysfunction post ST-elevation myocardial infarction

Idan Roifman, Nilesh Ghugre, Mohammad I. Zia, Michael E. Farkouh, Anna Zavodni, Graham A. Wright, Kim A. Connelly

Open Access Erratum

Erratum to: Apolipoprotein E gene polymorphism and risk of type 2 diabetes and cardiovascular disease

Dalia El-Lebedy, Hala M. Raslan, Asmaa M. Mohammed

Open Access Original Investigation

Insulin resistance, endothelial function, angiogenic factors and clinical outcome in non-diabetic patients with chest pain without myocardial perfusion defects

Helena U. Westergren, Sara Svedlund, Remi A. Momo, Juuso I. Blomster, Karin Wåhlander, Erika Rehnström, Peter J. Greasley, Regina Fritsche-Danielson, Jan Oscarsson, Li-Ming Gan

Open Access Original investigation

Cardiovascular effects of dapagliflozin in patients with type 2 diabetes and different risk categories: a meta-analysis

Christian Sonesson, Peter A. Johansson, Eva Johnsson, Ingrid Gause-Nilsson

Open Access Original investigation

Cardiovascular safety for once-weekly dulaglutide in type 2 diabetes: a pre-specified meta-analysis of prospectively adjudicated cardiovascular events

Keith C. Ferdinand, Fady T. Botros, Charles M. Atisso, Philip T. Sager

Open Access Original investigation

Long-term mortality and incidence of cardiovascular diseases and type 2 diabetes in diabetic and nondiabetic obese patients undergoing gastric banding: a controlled study

Antonio E. Pontiroli, Ahmed S. Zakaria, Ermanno Mantegazza, Alberto Morabito, Alessandro Saibene, Enrico Mozzi, Giancarlo Micheletto

Open Access Original investigation

Association of soluble tumor necrosis factor receptors 1 and 2 with nephropathy, cardiovascular events, and total mortality in type 2 diabetes

Axel C. Carlsson, Carl Johan Östgren, Fredrik H. Nystrom, Toste Länne, Pär Jennersjö, Anders Larsson, Johan Ärnlöv

Open Access Original Investigation

Interleukin-1β mediates high glucose induced phenotypic transition in human aortic endothelial cells

Dong-Dong Zhu, Ri-Ning Tang, Lin-Li Lv, Yi Wen, Hong Liu, Xiao-Liang Zhang, Kun-Ling Ma, Bi-Cheng Liu

Open Access Original investigation

The coexistence of carotid and lower extremity atherosclerosis further increases cardio-cerebrovascular risk in type 2 diabetes

Mei-Fang Li, Cui-Chun Zhao, Ting-Ting Li, Yin-Fang Tu, Jun-Xi Lu, Rong Zhang, Ming-Yun Chen, Yu-Qian Bao, Lian-Xi Li, Wei-Ping Jia

Open Access Review

Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy

Vidya Kandula, Ramoji Kosuru, Haobo Li, Dan Yan, Qiqi Zhu, Qingquan Lian, Ren-shan Ge, Zhengyuan Xia, Michael G. Irwin

Open Access Original investigation

Association of glucose homeostasis measures with heart rate variability among Hispanic/Latino adults without diabetes: the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Michelle L. Meyer, Nathan M. Gotman, Elsayed Z. Soliman, Eric A. Whitsel, Raanan Arens, Jianwen Cai, Martha L. Daviglus, Pablo Denes, Hector M. González, Juan Moreiras, Gregory A. Talavera, Gerardo Heiss

Open Access Original Investigation

Protective effect of resveratrol and quercetin on in vitro-induced diabetic mouse corpus cavernosum

Charlotte Boydens, Bart Pauwels, Laura Vanden Daele, Johan Van de Voorde

Open Access Original investigation

Metabolic markers associated with insulin resistance predict type 2 diabetes in Koreans with normal blood pressure or prehypertension

Ki-Chul Sung, Hyun-Young Park, Min-Ju Kim, Gerald Reaven

Open Access Original investigation

Cost-effectiveness of screening strategies to detect heart failure in patients with type 2 diabetes

Anoukh van Giessen, Leandra J. M. Boonman-de Winter, Frans H. Rutten, Maarten J. Cramer, Marcel J. Landman, Anho H. Liem, Arno W. Hoes, Hendrik Koffijberg

Open Access Original investigation

Vascular endothelial microparticles-incorporated microRNAs are altered in patients with diabetes mellitus

Felix Jansen, Han Wang, David Przybilla, Bernardo S. Franklin, Andreas Dolf, Philipp Pfeifer, Theresa Schmitz, Anna Flender, Elmar Endl, Georg Nickenig, Nikos Werner

Open Access Original Investigation

Association between insulin receptor substrate-1 polymorphisms and high platelet reactivity with clopidogrel therapy in coronary artery disease patients with type 2 diabetes mellitus

Dingyu Zhang, Xiaolin Zhang, Dan Liu, Tengfei Liu, Wenzhi Cai, Chenghui Yan, Yaling Han

Open Access Original investigation

Oxidative stress, inflammation, endothelial dysfunction and incidence of type 2 diabetes

Andrew O. Odegaard, David R. Jacobs Jr., Otto A. Sanchez, David C. Goff Jr., Alexander P. Reiner, Myron D. Gross

Open Access Original investigation

Flow cytometric analysis of platelets type 2 diabetes mellitus reveals ‘angry’ platelets

Prashilla Soma, Albe Carina Swanepoel, Jeanette Noel du Plooy, Thandi Mqoco, Etheresia Pretorius

Open Access Original investigation

Mitochondrial DNA damage and vascular function in patients with diabetes mellitus and atherosclerotic cardiovascular disease

Jessica L. Fetterman, Monica Holbrook, David G. Westbrook, Jamelle A. Brown, Kyle P. Feeley, Rosa Bretón-Romero, Erika A. Linder, Brittany D. Berk, Robert M. Weisbrod, Michael E. Widlansky, Noyan Gokce, Scott W. Ballinger, Naomi M. Hamburg

Open Access Original investigation

Cardiovascular efficacy of sitagliptin in patients with diabetes at high risk of cardiovascular disease: a 12-month follow-up

Takashi Nakamura, Yoshitaka Iwanaga, Yuki Miyaji, Ryuji Nohara, Takao Ishimura, Shunichi Miyazaki

Open Access Commentary

Need for streamlined use of DPP-4 inhibitors in the treatment of type 2 diabetes

Cristiana Vitale, Giuseppe M. C. Rosano, Krishna Prasad

Open Access Original investigation

A comparison between angiotensin converting enzyme inhibitors and angiotensin receptor blockers on end stage renal disease and major adverse cardiovascular events in diabetic patients: a population-based dynamic cohort study in Taiwan

Lung-Sheng Wu, Shang-Hung Chang, Gwo-Jyh Chang, Jia-Rou Liu, Yi-Hsin Chan, Hsin-Fu Lee, Ming-Shien Wen, Wei-Jan Chen, Yung-Hsin Yeh, Chi-Tai Kuo, Lai-Chu See

Open Access Study protocol

Rationale and design of a randomized trial to test the safety and non-inferiority of canagliflozin in patients with diabetes with chronic heart failure: the CANDLE trial

Atsushi Tanaka, Teruo Inoue, Masafumi Kitakaze, Jun-ichi Oyama, Masataka Sata, Isao Taguchi, Wataru Shimizu, Hirotaka Watada, Hirofumi Tomiyama, Junya Ako, Yasushi Sakata, Toshihisa Anzai, Masaaki Uematsu, Makoto Suzuki, Kazuo Eguchi, Akira Yamashina, Yoshihiko Saito, Yasunori Sato, Shinichiro Ueda, Toyoaki Murohara, Koichi Node

Open Access Original investigation

The influence of body composition on the N-terminal pro-B-type natriuretic peptide level and its prognostic performance in patients with acute coronary syndrome: a cohort study

Fang-Yang Huang, Hua Wang, Bao-Tao Huang, Wei Liu, Yong Peng, Chen Zhang, Tian-Li Xia, Peng-Ju Wang, Zhi-Liang Zuo, Yue Heng, Rui-Shuang Liu, Xiao-Bo Pu, Yi-Yue Gui, Shi-Jian Chen, Ye Zhu, Mao Chen

Open Access Study protocol

Cohort profile: the German Diabetes Study (GDS)

Julia Szendroedi, Aaruni Saxena, Katharina S. Weber, Klaus Strassburger, Christian Herder, Volker Burkart, Bettina Nowotny, Andrea Icks, Oliver Kuss, Dan Ziegler, Hadi Al-Hasani, Karsten Müssig, Michael Roden

Open Access Original investigation

Determinants of growth differentiation factor 15 in patients with stable and acute coronary artery disease. A prospective observational study

Serdar Farhan, Matthias K. Freynhofer, Ivan Brozovic, Veronika Bruno, Birgit Vogel, Ioannis Tentzeris, Sabina Baumgartner-Parzer, Kurt Huber, Alexandra Kautzky-Willer

Open Access Original investigation

Association between socioeconomic status and metabolic control and diabetes complications: a cross-sectional nationwide study in Chinese adults with type 2 diabetes mellitus

Xiaoming Tao, Jihu Li, Xiaolin Zhu, Bin Zhao, Jiao Sun, Linong Ji, Dayi Hu, Changyu Pan, Yuxin Huang, Suyuan Jiang, Qiang Feng, Cuiping Jiang

Open Access Original investigation

Nicorandil attenuates carotid intimal hyperplasia after balloon catheter injury in diabetic rats

Ying Qian Zhang, Feng Tian, Ying Zhou, Yun Dai Chen, Bo Li, Qiang Ma, Ying Zhang

Open Access Original investigation

Berberine alleviates the cerebrovascular contractility in streptozotocin-induced diabetic rats through modulation of intracellular Ca2+ handling in smooth muscle cells

Yu-Guang Ma, Yin-Bin Zhang, Yun-Gang Bai, Zhi-Jun Dai, Liang Liang, Mei Liu, Man-Jiang Xie, Hai-Tao Guan

Open Access Original Investigation

Clinical relevance of dual-energy X-ray absorptiometry (DXA) as a simultaneous evaluation of fatty liver disease and atherosclerosis in patients with type 2 diabetes

Ryotaro Bouchi, Yujiro Nakano, Norihiko Ohara, Takato Takeuchi, Masanori Murakami, Masahiro Asakawa, Yuriko Sasahara, Mitsuyuki Numasawa, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa

Open Access Original investigation

Metabolically-inactive glucagon-like peptide-1(9–36)amide confers selective protective actions against post-myocardial infarction remodelling

Emma Robinson, Mitchel Tate, Samuel Lockhart, Claire McPeake, Karla M. O’Neill, Kevin S. Edgar, Danielle Calderwood, Brian D. Green, Barbara J. McDermott, David J. Grieve

Open Access Original investigation

Severely impaired microvascular reactivity in diabetic patients with an acute coronary syndrome

Nikolaos Östlund Papadogeorgos, Gun Jörneskog, Mattias Bengtsson, Thomas Kahan, Majid Kalani

Open Access Original investigation

Impaired coronary microcirculation in type 2 diabetic patients is associated with elevated circulating regulatory T cells and reduced number of IL-21R+ T cells

Bernt Johan von Scholten, Alexander Rosendahl, Philip Hasbak, Regine Bergholdt, Andreas Kjaer, Peter Rossing, Tine W. Hansen

Open Access Original investigation

Hepatic insulin resistance both in prediabetic and diabetic patients determines postprandial lipoprotein metabolism: from the CORDIOPREV study

A. Leon-Acuña, J. F. Alcala-Diaz, J. Delgado-Lista, J. D. Torres-Peña, J. Lopez-Moreno, A. Camargo, A. Garcia-Rios, C. Marin, F. Gomez-Delgado, J. Caballero, B. Van-Ommen, M. M. Malagon, P. Perez-Martinez, J. Lopez-Miranda

Open Access Original investigation

The clinical value of metabolic syndrome and risks of cardiometabolic events and mortality in the elderly: the Rotterdam study

Thijs T. W. van Herpt, Abbas Dehghan, Mandy van Hoek, M. Arfan Ikram, Albert Hofman, Eric J. G. Sijbrands, Oscar H. Franco

Open Access Original investigation

The source of circulating selenoprotein S and its association with type 2 diabetes mellitus and atherosclerosis: a preliminary study

Shan-shan Yu, Li–li Men, Jia-ling Wu, Li-wei Huang, Qian Xing, Jun-jie Yao, Yong-bo Wang, Gui-rong Song, Hui-shu Guo, Guo-hua Sun, Yu-hong Zhang, Hua Li, Jian-ling Du

Open Access Original investigation

Oscillating glucose induces microRNA-185 and impairs an efficient antioxidant response in human endothelial cells

Lucia La Sala, Monica Cattaneo, Valeria De Nigris, Gemma Pujadas, Roberto Testa, Anna R. Bonfigli, Stefano Genovese, Antonio Ceriello

Open Access Original investigation

Achievement of treatment goals for secondary prevention of myocardial infarction or stroke in 29,325 patients with type 2 diabetes: a German/Austrian DPV-multicenter analysis

Barbara Bohn, Christof Schöfl, Vincent Zimmer, Michael Hummel, Nikolai Heise, Erhard Siegel, Wolfram Karges, Michaela Riedl, Reinhard W. Holl

Open Access Original investigation

Low birth weight leads to obesity, diabetes and increased leptin levels in adults: the CoLaus study

François R. Jornayvaz, Peter Vollenweider, Murielle Bochud, Vincent Mooser, Gérard Waeber, Pedro Marques-Vidal

Open Access Original investigation

Oral treatment with a zinc complex of acetylsalicylic acid prevents diabetic cardiomyopathy in a rat model of type-2 diabetes: activation of the Akt pathway

Sevil Korkmaz-Icöz, Samer Al Said, Tamás Radovits, Shiliang Li, Maik Brune, Péter Hegedűs, Ayhan Atmanli, Mihály Ruppert, Paige Brlecic, Lorenz Heyne Lehmann, Bernd Lahrmann, Niels Grabe, Yutaka Yoshikawa, Hiroyuki Yasui, Patrick Most, Matthias Karck, Gábor Szabó

Open Access Original investigation

Impact of teneligliptin on oxidative stress and endothelial function in type 2 diabetes patients with chronic kidney disease: a case–control study

Masaaki Sagara, Kunihiro Suzuki, Chie Aoki, Seiichi Tanaka, Isao Taguchi, Teruo Inoue, Yoshimasa Aso

Open Access Original investigation

Impact of individual metabolic risk components or its clustering on endothelial and smooth muscle cell function in men

Michio Shimabukuro, Namio Higa, Hiroaki Masuzaki, Masataka Sata, Shinichiro Ueda

Open Access Original investigation

Major adverse cardiovascular events with basal insulin peglispro versus comparator insulins in patients with type 1 or type 2 diabetes: a meta-analysis

Byron J. Hoogwerf, A. Michael Lincoff, Angel Rodriguez, Lei Chen, Yongming Qu

Open Access Original investigation

Effects of daily glucose fluctuations on the healing response to everolimus-eluting stent implantation as assessed using continuous glucose monitoring and optical coherence tomography

Masaru Kuroda, Toshiro Shinke, Hiromasa Otake, Daisuke Sugiyama, Tomofumi Takaya, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Natsuko Tahara, Daiji Kashiwagi, Koji Kuroda, Yuto Shinkura, Yoshinori Nagasawa, Kazuhiko Sakaguchi, Yushi Hirota, Wataru Ogawa, Ken-ichi Hirata

Open Access Original investigation

Palaeolithic diet decreases fasting plasma leptin concentrations more than a diabetes diet in patients with type 2 diabetes: a randomised cross-over trial

Maelán Fontes-Villalba, Staffan Lindeberg, Yvonne Granfeldt, Filip K. Knop, Ashfaque A. Memon, Pedro Carrera-Bastos, Óscar Picazo, Madhvi Chanrai, Jan Sunquist, Kristina Sundquist, Tommy Jönsson

Open Access Original Investigation

Statin use and cardiovascular risk factors in diabetic patients developing a first myocardial infarction

Martin Bødtker Mortensen, Imra Kulenovic, Erling Falk

Open Access Original investigation

Inflammation, glucose, and vascular cell damage: the role of the pentose phosphate pathway

Concepción Peiró, Tania Romacho, Verónica Azcutia, Laura Villalobos, Emilio Fernández, Juan P. Bolaños, Salvador Moncada, Carlos F. Sánchez-Ferrer

Open Access Original investigation

Diastolic orthostatic hypertension and cardiovascular prognosis in type 2 diabetes: a prospective cohort study

Magnus Wijkman, Toste Länne, Carl Johan Östgren, Fredrik H. Nystrom

Open Access Original investigation

The nine-year changes of the incidence and characteristics of metabolic syndrome in China: longitudinal comparisons of the two cross-sectional surveys in a newly formed urban community

Boren Jiang, Bin Li, Yongbin Wang, Bing Han, Ningjian Wang, Qin Li, Weihong Yang, Guolan Huang, Jinhua Wang, Yi Chen, Yingchao Chen, Chunfang Zhu, Dongping Lin, Yingli Lu

Open Access Original investigation

Beyond type 2 diabetes, obesity and hypertension: an axis including sleep apnea, left ventricular hypertrophy, endothelial dysfunction, and aortic stiffness among Mexican Americans in Starr County, Texas

Craig L. Hanis, Susan Redline, Brian E. Cade, Graeme I. Bell, Nancy J. Cox, Jennifer E. Below, Eric L. Brown, David Aguilar

Open Access Study protocol

Rationale and design of a multicenter randomized study for evaluating vascular function under uric acid control using the xanthine oxidase inhibitor, febuxostat: the PRIZE study

Jun-ichi Oyama, Atsushi Tanaka, Yasunori Sato, Hirofumi Tomiyama, Masataka Sata, Tomoko Ishizu, Isao Taguchi, Takanori Kuroyanagi, Hiroki Teragawa, Nobukazu Ishizaka, Yumiko Kanzaki, Mitsuru Ohishi, Kazuo Eguchi, Yukihito Higashi, Hirotsugu Yamada, Koji Maemura, Junya Ako, Yasuko K. Bando, Shinichiro Ueda, Teruo Inoue, Toyoaki Murohara, Koichi Node

Open Access Original investigation

Metformin improves the angiogenic functions of endothelial progenitor cells via activating AMPK/eNOS pathway in diabetic mice

Jia-Wen Yu, Ya-Ping Deng, Xue Han, Guo-Fei Ren, Jian Cai, Guo-Jun Jiang

Open Access Original investigation

Efficacy and safety of canagliflozin in combination with insulin: a double-blind, randomized, placebo-controlled study in Japanese patients with type 2 diabetes mellitus

Nobuya Inagaki, Shin-ichi Harashima, Nobuko Maruyama, Yutaka Kawaguchi, Maki Goda, Hiroaki Iijima

Open Access Original investigation

Association between omentin-1 expression in human epicardial adipose tissue and coronary atherosclerosis

Yu Du, Qingwei Ji, Lun Cai, Fangjiong Huang, Yongqiang Lai, Yue Liu, Jianbo Yu, Bo Han, Enjun Zhu, Jinwei Zhang, Yujie Zhou, Zhijian Wang, Yingxin Zhao

Open Access Original investigation

Alterations in heart rate variability during everyday life are linked to insulin resistance. A role of dominating sympathetic over parasympathetic nerve activity?

Maria K. Svensson, Stina Lindmark, Urban Wiklund, Peter Rask, Marcus Karlsson, Jan Myrin, Joel Kullberg, Lars Johansson, Jan W. Eriksson

Open Access Original investigation

Impact of metabolic syndrome on the progression of coronary calcium and of coronary artery disease assessed by repeated cardiac computed tomography scans

Lee Kyung Kim, Ji Won Yoon, Dong-Hwa Lee, Kyoung Min Kim, Sung Hee Choi, Kyong Soo Park, Hak Chul Jang, Min-Kyung Kim, Hyo Eun Park, Su-Yeon Choi, Soo Lim

Open Access Original investigation

Effect of obesity on the effectiveness of cardiac resynchronization to reduce the risk of first and recurrent ventricular tachyarrhythmia events

Barbara Szepietowska, Bronislava Polonsky, Saadia Sherazi, Yitschak Biton, Valentina Kutyifa, Scott McNitt, Mehmet Aktas, Arthur J. Moss, Wojciech Zareba

Open Access Original investigation

Dipeptidyl peptidase-4 inhibition with linagliptin prevents western diet-induced vascular abnormalities in female mice

Camila Manrique, Javad Habibi, Annayya R. Aroor, James R. Sowers, Guanghong Jia, Melvin R. Hayden, Mona Garro, Luis A. Martinez-Lemus, Francisco I. Ramirez-Perez, Thomas Klein, Gerald A. Meininger, Vincent G. DeMarco

Open Access Original investigation

Effect of the long-acting insulin analogues glargine and degludec on cardiomyocyte cell signalling and function

Thorsten Hartmann, Sabrina Overhagen, D. Margriet Ouwens, Silja Raschke, Paulus Wohlfart, Norbert Tennagels, Nina Wronkowitz, Jürgen Eckel

Open Access Methodology

Research into the effect Of SGLT2 inhibition on left ventricular remodelling in patients with heart failure and diabetes mellitus (REFORM) trial rationale and design

Jagdeep S. S. Singh, Amir Fathi, Keeran Vickneson, Ify Mordi, Mohapradeep Mohan, J. Graeme Houston, Ewan R. Pearson, Allan D. Struthers, Chim C. Lang

Open Access Original investigation

The relationship between HbA1c and ultrasound plaque textures in atherosclerotic patients

Xiao-Wei Huang, Yan-Ling Zhang, Long Meng, Ming Qian, Wei Zhou, Rong-Qin Zheng, Hai-Rong Zheng, Li–Li Niu

Open Access Original investigation

Glucagon-like peptide-1 derived cardioprotection does not utilize a KATP-channel dependent pathway: mechanistic insights from human supply and demand ischemia studies

Joel P. Giblett, Richard G. Axell, Paul A. White, Sophie J. Clarke, Liam McCormick, Philip A. Read, Johannes Reinhold, Adam J. Brown, Michael O’Sullivan, Nick E. J. West, David P. Dutka, Stephen P. Hoole

Open Access Original investigation

Clinical outcomes of deferred revascularisation using fractional flow reserve in patients with and without diabetes mellitus

Mark W. Kennedy, Eliza Kaplan, Rik S. Hermanides, Enrico Fabris, Veemal Hemradj, Petra C. Koopmans, Jan-Hank E. Dambrink, A. T. Marcel Gosselink, Arnoud W. J. van‘t Hof, Jan Paul Ottervanger, Vincent Roolvink, Wouter S. Remkes, Aize van der Sluis, Harry Suryapranata, Elvin Kedhi

Open Access Original investigation

The influence of baseline risk on the relation between HbA1c and risk for new cardiovascular events and mortality in patients with type 2 diabetes and symptomatic cardiovascular disease

Sophie H. Bots, Yolanda van der Graaf, Hendrik M. W. Nathoe, Gert Jan de Borst, Jaap L. Kappelle, Frank L. J. Visseren, Jan Westerink

Open Access Study protocol

Rationale and design of the randomised controlled trial to assess the impact of liraglutide on cardiac function and structure in young adults with type 2 diabetes (the LYDIA study)

Z. Z. Htike, T. Yates, E. M. Brady, D. Webb, L. J. Gray, D. Swarbrick, G. P. McCann, K. Khunti, M. J. Davies

Open Access Erratum

Erratum to: National trends in incidence and outcomes of abdominal aortic aneurysm among elderly type 2 diabetic and non-diabetic patients in Spain (2003–2012)

Ana Lopez-de-Andrés, Isabel Jiménez-Trujillo, Rodrigo Jiménez-García, Valentín Hernández-Barrera, José Mª de Miguel-Yanes, Manuel Méndez-Bailón, Napoleón Perez-Farinos, Miguel Ángel Salinero-Fort, Pilar Carrasco-Garrido

Open Access Original investigation

Atherogenic dyslipidemia and risk of silent coronary artery disease in asymptomatic patients with type 2 diabetes: a cross-sectional study

Paul Valensi, Antoine Avignon, Ariane Sultan, Bernard Chanu, Minh Tuan Nguyen, Emmanuel Cosson

Open Access Original investigation

Effects of the glucagon-like peptide-1 receptor agonist liraglutide on systolic function in patients with coronary artery disease and type 2 diabetes: a randomized double-blind placebo-controlled crossover study

Preman Kumarathurai, Christian Anholm, Olav W. Nielsen, Ole P. Kristiansen, Jens Mølvig, Sten Madsbad, Steen B. Haugaard, Ahmad Sajadieh

Open Access Original investigation

The influence of body composition on renal function in patients with coronary artery disease and its prognostic significance: a retrospective cohort study

Yong Peng, Hua Wang, Fei Chen, Fang-yang Huang, Tian-li Xia, Yan-biao Liao, Hua Chai, Peng-ju Wang, Zhi-liang Zuo, Wei Liu, Chen Zhang, Yi-jian Li, Yi-yue Gui, Mao Chen, De-jia Huang

Open Access Original investigation

Circulating PCSK9 levels and CETP plasma activity are independently associated in patients with metabolic diseases

Josefa Girona, Daiana Ibarretxe, Nuria Plana, Sandra Guaita-Esteruelas, Nuria Amigo, Mercedes Heras, Luis Masana

Open Access Original investigation

Serum gamma-glutamyltransferase is not associated with subclinical atherosclerosis in patients with type 2 diabetes

Hye Eun Yoon, Eun Young Mo, Seok Joon Shin, Sung Dae Moon, Je Ho Han, Eun Sook Kim

Open Access Original investigation

Acute blood glucose fluctuation enhances rat aorta endothelial cell apoptosis, oxidative stress and pro-inflammatory cytokine expression in vivo

Na Wu, Haitao Shen, Henan Liu, Yanjun Wang, Yu Bai, Ping Han

Open Access Original investigation

Transcriptomic alterations in the heart of non-obese type 2 diabetic Goto-Kakizaki rats

Márta Sárközy, Gergő Szűcs, Veronika Fekete, Márton Pipicz, Katalin Éder, Renáta Gáspár, Andrea Sója, Judit Pipis, Péter Ferdinandy, Csaba Csonka, Tamás Csont

Open Access Review

Continued efforts to translate diabetes cardiovascular outcome trials into clinical practice

Angelo Avogaro, Gian Paolo Fadini, Giorgio Sesti, Enzo Bonora, Stefano Del Prato

Open Access Original investigation

Glucose intolerance after chronic stress is related with downregulated PPAR-γ in adipose tissue

Vitor H. Pereira, Fernanda Marques, Vânia Lages, Filipa G. Pereira, Alexandre Patchev, Osborne F. X. Almeida, Joana Almeida-Palha, Nuno Sousa, João J. Cerqueira

Open Access Original investigation

Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids

Katherine E. Beaney, Jackie A. Cooper, Stela McLachlan, S. Goya Wannamethee, Barbara J. Jefferis, Peter Whincup, Yoav Ben-Shlomo, Jacqueline F. Price, Meena Kumari, Andrew Wong, Ken Ong, Rebecca Hardy, Diana Kuh, Mika Kivimaki, Antti J. Kangas, Pasi Soininen, Mika Ala-Korpela, Fotios Drenos, Steve E. Humphries

Open Access Original investigation

Metformin improves circulating endothelial cells and endothelial progenitor cells in type 1 diabetes: MERIT study

Fahad W. Ahmed, Rachel Rider, Michael Glanville, Kilimangalam Narayanan, Salman Razvi, Jolanta U. Weaver

Open Access Original investigation

Associations between blood glucose level and outcomes of adult in-hospital cardiac arrest: a retrospective cohort study

Chih-Hung Wang, Chien-Hua Huang, Wei-Tien Chang, Min-Shan Tsai, Ping-Hsun Yu, Yen-Wen Wu, Wen-Jone Chen

Open Access Original investigation

TNF-α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice

Rafael Menezes da Costa, Karla Bianca Neves, Fabíola Leslie Mestriner, Paulo Louzada-Junior, Thiago Bruder-Nascimento, Rita C. Tostes

Open Access Original investigation

Common dysregulated pathways in obese adipose tissue and atherosclerosis

V. Moreno-Viedma, M. Amor, A. Sarabi, M. Bilban, G. Staffler, M. Zeyda, T. M. Stulnig

Open Access Original Investigation

Effects of 6-month eicosapentaenoic acid treatment on postprandial hyperglycemia, hyperlipidemia, insulin secretion ability, and concomitant endothelial dysfunction among newly-diagnosed impaired glucose metabolism patients with coronary artery disease. An open label, single blinded, prospective randomized controlled trial

Takahiro Sawada, Hideo Tsubata, Naoko Hashimoto, Michinori Takabe, Taishi Miyata, Kosuke Aoki, Soichiro Yamashita, Shogo Oishi, Tsuyoshi Osue, Kiminobu Yokoi, Yasue Tsukishiro, Tetsuari Onishi, Akira Shimane, Yasuyo Taniguchi, Yoshinori Yasaka, Takeshi Ohara, Hiroya Kawai, Mitsuhiro Yokoyama

Open Access Original investigation

Association between dietary acid load and the risk of cardiovascular disease: nationwide surveys (KNHANES 2008–2011)

Eugene Han, Gyuri Kim, Namki Hong, Yong-ho Lee, Dong Woo Kim, Hyun Joon Shin, Byung-Wan Lee, Eun Seok Kang, In-Kyu Lee, Bong-Soo Cha

Open Access Review

Glucagon and heart in type 2 diabetes: new perspectives

Antonio Ceriello, Stefano Genovese, Edoardo Mannucci, Edoardo Gronda

Open Access Original investigation

Five-year clinical outcomes in patients with diabetes mellitus treated with polymer-free sirolimus- and probucol-eluting stents versus second-generation zotarolimus-eluting stents: a subgroup analysis of a randomized controlled trial

Yukinori Harada, Roisin Colleran, Sebastian Kufner, Daniele Giacoppo, Tobias Rheude, Jonathan Michel, Salvatore Cassese, Tareq Ibrahim, Karl-Ludwig Laugwitz, Adnan Kastrati, Robert A. Byrne

Open Access Original investigation

Association between use of oral-antidiabetic drugs and the risk of aortic aneurysm: a nested case–control analysis

Chien-Yi Hsu, Yu-Wen Su, Yung-Tai Chen, Shih-Hung Tsai, Chun-Chin Chang, Szu-Yuan Li, Po-Hsun Huang, Jaw-Wen Chen, Shing-Jong Lin

Open Access Original investigation

Apocynin influence on oxidative stress and cardiac remodeling of spontaneously hypertensive rats with diabetes mellitus

C. M. Rosa, R. Gimenes, D. H. S. Campos, G. N. Guirado, C. Gimenes, A. A. H. Fernandes, A. C. Cicogna, R. M. Queiroz, I. Falcão-Pires, D. Miranda-Silva, P. Rodrigues, F. R. Laurindo, D. C. Fernandes, C. R. Correa, M. P. Okoshi, K. Okoshi

Open Access Original investigation

Skin autofluorescence predicts cardio-renal outcome in type 1 diabetes: a longitudinal study

Fritz-Line Vélayoudom-Céphise, Kalina Rajaobelina, Catherine Helmer, Sovanndany Nov, Emilie Pupier, Laurence Blanco, Marie Hugo, Blandine Farges, Cyril Astrugue, Henri Gin, Vincent Rigalleau

Open Access Original investigation

Adequate vitamin D status is associated with the reduced odds of prevalent diabetic retinopathy in African Americans and Caucasians

Amy E. Millen, Michelle W. Sahli, Jing Nie, Michael J. LaMonte, Pamela L. Lutsey, Barbara E. K. Klein, Julie A. Mares, Kirstin J. Meyers, Christopher A. Andrews, Ronald Klein

Open Access Original investigation

Presentations of major peripheral arterial disease and risk of major outcomes in patients with type 2 diabetes: results from the ADVANCE-ON study

Kamel Mohammedi, Mark Woodward, Yoichiro Hirakawa, Sophia Zoungas, Stephen Colagiuri, Pavel Hamet, Stephen Harrap, Neil Poulter, David R. Matthews, Michel Marre, John Chalmers

Open Access Original investigation

Mortality and causes of death in a national sample of type 2 diabetic patients in Korea from 2002 to 2013

Yu Mi Kang, Ye-Jee Kim, Joong-Yeol Park, Woo Je Lee, Chang Hee Jung

Open Access Original investigation

Different relationship between ANGPTL3 and HDL components in female non-diabetic subjects and type-2 diabetic patients

Dong Zhao, Long-Yan Yang, Xu-Hong Wang, Sha-Sha Yuan, Cai-Guo Yu, Zong-Wei Wang, Jia-Nan Lang, Ying-Mei Feng

Open Access Study protocol

Rationale and design of a multicenter randomized controlled study to evaluate the preventive effect of ipragliflozin on carotid atherosclerosis: the PROTECT study

Atsushi Tanaka, Toyoaki Murohara, Isao Taguchi, Kazuo Eguchi, Makoto Suzuki, Masafumi Kitakaze, Yasunori Sato, Tomoko Ishizu, Yukihito Higashi, Hirotsugu Yamada, Mamoru Nanasato, Michio Shimabukuro, Hiroki Teragawa, Shinichiro Ueda, Satoshi Kodera, Munehide Matsuhisa, Toshiaki Kadokami, Kazuomi Kario, Yoshihiko Nishio, Teruo Inoue, Koji Maemura, Jun-ichi Oyama, Mitsuru Ohishi, Masataka Sata, Hirofumi Tomiyama, Koichi Node

Open Access Original investigation

Long-term effect of sitagliptin on endothelial function in type 2 diabetes: a sub-analysis of the PROLOGUE study

Tatsuya Maruhashi, Yukihito Higashi, Yasuki Kihara, Hirotsugu Yamada, Masataka Sata, Shinichiro Ueda, Masato Odawara, Yasuo Terauchi, Kazuoki Dai, Jun Ohno, Masato Iida, Hiroaki Sano, Hirofumi Tomiyama, Teruo Inoue, Atsushi Tanaka, Toyoaki Murohara, Koichi Node

Open Access Original investigation

The effect of perioperative insulin treatment on cardiodepression in mild adiposity in mice

Chantal A. Boly, Etto C. Eringa, R. Arthur Bouwman, Rob F. P. van den Akker, Frances S. de Man, Ingrid Schalij, Stephan A. Loer, Christa Boer, Charissa E. van den Brom

Open Access Original investigation

Acute hyperglycemia suppresses left ventricular diastolic function and inhibits autophagic flux in mice under prohypertrophic stimulation

Jiahe Xie, Kai Cui, Huixin Hao, Yingxue Zhang, Hairuo Lin, Zhenhuan Chen, Xiaobo Huang, Shiping Cao, Wangjun Liao, Jianping Bin, Masafumi Kitakaze, Yulin Liao

Open Access Original investigation

Cholesterol remnants and triglycerides are associated with decreased myocardial function in patients with type 2 diabetes

Peter Godsk Jørgensen, Magnus Thorsten Jensen, Tor Biering-Sørensen, Rasmus Mogelvang, Søren Galatius, Thomas Fritz-Hansen, Peter Rossing, Tina Vilsbøll, Jan Skov Jensen

Open Access Original investigation

Associations between explorative dietary patterns and serum lipid levels and their interactions with ApoA5 and ApoE haplotype in patients with recently diagnosed type 2 diabetes

Katharina S. Weber, Birgit Knebel, Klaus Strassburger, Jörg Kotzka, Peter Stehle, Julia Szendroedi, Karsten Müssig, Anette E. Buyken, Michael Roden

Open Access Review

Current perspectives on cardiovascular outcome trials in diabetes

Oliver Schnell, Lars Rydén, Eberhard Standl, Antonio Ceriello

Open Access Original investigation

Association of serum calcium and heart failure with preserved ejection fraction in patients with type 2 diabetes

Junfeng Li, Nan Wu, Wenling Dai, Liu Jiang, Yintao Li, Shibao Li, Zhongyuan Wen

Open Access Original investigation

A 19-SNP coronary heart disease gene score profile in subjects with type 2 diabetes: the coronary heart disease risk in type 2 diabetes (CoRDia study) study baseline characteristics

Katherine E. Beaney, Claire E. Ward, Dauda A. S. Bappa, Nadine McGale, Anna K. Davies, Shashivadan P. Hirani, KaWah Li, Philip Howard, Dwaine R. Vance, Martin A. Crockard, John V. Lamont, Stanton Newman, Steve E. Humphries

Open Access Original investigation

Vitamin D modifies the associations between circulating betatrophin and cardiometabolic risk factors among youths at risk for metabolic syndrome

Junling Fu, Cong Hou, Lujiao Li, Dan Feng, Ge Li, Mingyao Li, Changhong Li, Shan Gao, Ming Li

Open Access Original investigation

Serum bicarbonate concentration and the risk of cardiovascular disease and death in type 2 diabetes: the Fremantle Diabetes Study

S. A. Paul Chubb, Wendy A. Davis, Kirsten E. Peters, Timothy M. E. Davis

Open Access Study protocol

Combined optical coherence tomography morphologic and fractional flow reserve hemodynamic assessment of non- culprit lesions to better predict adverse event outcomes in diabetes mellitus patients: COMBINE (OCT–FFR) prospective study. Rationale and design

Mark W. Kennedy, Enrico Fabris, Alexander J. Ijsselmuiden, Holger Nef, Sebastian Reith, Javier Escaned, Fernando Alfonso, Niels van Royen, Wojtek Wojakowski, Adam Witkowski, Ciro Indolfi, Jan Paul Ottervanger, Harry Suryapranata, Elvin Kedhi

Open Access Original investigation

Low and exacerbated levels of 1,5-anhydroglucitol are associated with cardiovascular events in patients after first-time elective percutaneous coronary intervention

Shuhei Takahashi, Kazunori Shimada, Katsumi Miyauchi, Tetsuro Miyazaki, Eiryu Sai, Manabu Ogita, Shuta Tsuboi, Hiroshi Tamura, Shinya Okazaki, Tomoyuki Shiozawa, Shohei Ouchi, Tatsuro Aikawa, Tomoyasu Kadoguchi, Hamad Al Shahi, Takuma Yoshihara, Makoto Hiki, Kikuo Isoda, Hiroyuki Daida

Open Access Original investigation

N-acetylcysteine attenuates myocardial dysfunction and postischemic injury by restoring caveolin-3/eNOS signaling in diabetic rats

Wating Su, Yuan Zhang, Qiongxia Zhang, Jinjin Xu, Liying Zhan, Qiqi Zhu, Qingquan Lian, Huimin Liu, Zhong-yuan Xia, Zhengyuan Xia, Shaoqing Lei

Open Access Original investigation

Moderate-intensity statin therapy seems ineffective in primary cardiovascular prevention in patients with type 2 diabetes complicated by nephropathy. A multicenter prospective 8 years follow up study

Ferdinando Carlo Sasso, Nadia Lascar, Antonella Ascione, Ornella Carbonara, Luca De Nicola, Roberto Minutolo, Teresa Salvatore, Maria Rosaria Rizzo, Plinio Cirillo, Giuseppe Paolisso, Raffaele Marfella

Open Access Original investigation

Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross-sectional trial

Leticia Gomez-Sanchez, Luis Garcia-Ortiz, M. Carmen Patino-Alonso, Jose I. Recio-Rodriguez, Rigo Fernando, Ruth Marti, Cristina Agudo-Conde, Emiliano Rodriguez-Sanchez, Jose A. Maderuelo-Fernandez, Rafel Ramos, Manuel A. Gomez-Marcos

Open Access Original investigation

Metabolic syndrome is independently associated with increased 20-year mortality in patients with stable coronary artery disease

Arwa Younis, Anan Younis, Boaz Tzur, Yael Peled, Nir Shlomo, Ilan Goldenberg, Enrique Z. Fisman, Alexander Tenenbaum, Robert Klempfner

Open Access Original investigation

Impact of glycemic control with sitagliptin on the 2-year progression of arterial stiffness: a sub-analysis of the PROLOGUE study

Hirofumi Tomiyama, Takashi Miwa, Kenshi Kan, Munehide Matsuhisa, Haruo Kamiya, Mamoru Nanasato, Tomoki Kitano, Hiroaki Sano, Jun Ohno, Masato Iida, Masataka Sata, Hirotsugu Yamada, Koji Maemura, Atsushi Tanaka, Toyoaki Murohara, Koichi Node

Open Access Original investigation

Impact of diabetes on the predictive value of heart failure biomarkers

Nuria Alonso, Josep Lupón, Jaume Barallat, Marta de Antonio, Mar Domingo, Elisabet Zamora, Pedro Moliner, Amparo Galán, Javier Santesmases, Cruz Pastor, Dídac Mauricio, Antoni Bayes-Genis

Open Access Original investigation

Effect of trelagliptin on vascular endothelial functions and serum adiponectin level in patients with type 2 diabetes: a preliminary single-arm prospective pilot study

Satoshi Ida, Kazuya Murata, Katunori Betou, Chiaki Kobayashi, Yuki Ishihara, Kanako Imataka, Akihiro Uchida, Kou Monguchi, Ryutaro Kaneko, Ryoko Fujiwara, Hiroka Takahashi

Open Access Original investigation

Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels

Elisa Lucas, Rocio Vila-Bedmar, Alba C. Arcones, Marta Cruces-Sande, Victoria Cachofeiro, Federico Mayor Jr., Cristina Murga

Open Access Original investigation

Correlation between insulin-induced estrogen receptor methylation and atherosclerosis

Jia Min, Zhong Weitian, Cai Peng, Peng Yan, Zhang Bo, Wang Yan, Bai Yun, Wang Xukai

Open Access Original investigation

Empagliflozin lessened cardiac injury and reduced visceral adipocyte hypertrophy in prediabetic rats with metabolic syndrome

Hiroaki Kusaka, Nobutaka Koibuchi, Yu Hasegawa, Hisao Ogawa, Shokei Kim-Mitsuyama

Open Access Review

Relationship of cardiometabolic parameters in non-smokers, current smokers, and quitters in diabetes: a systematic review and meta-analysis

Debasish Kar, Clare Gillies, Francesco Zaccardi, David Webb, Samuel Seidu, Solomon Tesfaye, Melanie Davies, Kamlesh Khunti

Open Access Original investigation

Impact of visceral fat on gene expression profile in peripheral blood cells in obese Japanese subjects

Yoshinari Obata, Norikazu Maeda, Yuya Yamada, Koji Yamamoto, Seiji Nakamura, Masaya Yamaoka, Yoshimitsu Tanaka, Shigeki Masuda, Hirofumi Nagao, Shiro Fukuda, Yuya Fujishima, Shunbun Kita, Hitoshi Nishizawa, Tohru Funahashi, Ken-ichi Matsubara, Yuji Matsuzawa, Iichiro Shimomura

Open Access Original investigation

Characteristics and outcomes of diabetic patients with an implantable cardioverter defibrillator in a real world setting: results from the Israeli ICD registry

Hillel Steiner, Michael Geist, Ilan Goldenberg, Mahmoud Suleiman, Michael Glikson, Alexander Tenenbaum, Moshe Swissa, Enrique Z. Fisman, Gregory Golovchiner, Boris Strasberg, Alon Barsheshet

Open Access Original investigation

Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis

N. Beneit, C. E. Fernández-García, J. L. Martín-Ventura, L. Perdomo, Ó. Escribano, J. B. Michel, G. García-Gómez, S. Fernández, S. Díaz-Castroverde, J. Egido, A. Gómez-Hernández, M. Benito

Open Access Original investigation

Liraglutide improves metabolic parameters and carotid intima-media thickness in diabetic patients with the metabolic syndrome: an 18-month prospective study

Manfredi Rizzo, Ali A. Rizvi, Angelo Maria Patti, Dragana Nikolic, Rosaria Vincenza Giglio, Giuseppa Castellino, Giovanni Li Volti, Massimiliano Caprio, Giuseppe Montalto, Vincenzo Provenzano, Stefano Genovese, Antonio Ceriello

Open Access Original investigation

Ankle-brachial index and incident diabetes mellitus: the atherosclerosis risk in communities (ARIC) study

Simin Hua, Laura R. Loehr, Hirofumi Tanaka, Gerardo Heiss, Josef Coresh, Elizabeth Selvin, Kunihiro Matsushita

Open Access Original investigation

Impact of obesity and epicardial fat on early left atrial dysfunction assessed by cardiac MRI strain analysis

Morgane Evin, Kathryn M. Broadhouse, Fraser M. Callaghan, Rachel T. McGrath, Sarah Glastras, Rebecca Kozor, Samantha L. Hocking, Jérôme Lamy, Alban Redheuil, Nadjia Kachenoura, Greg R. Fulcher, Gemma A. Figtree, Stuart M. Grieve

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.