Issue 4/2020
Content (13 Articles)
The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics
Sarah A. Kent, Tara L. Spires-Jones, Claire S. Durrant
ADNC-RS, a clinical-genetic risk score, predicts Alzheimer’s pathology in autopsy-confirmed Parkinson’s disease and Dementia with Lewy bodies
David L. Dai, Thomas F. Tropea, John L. Robinson, Eunran Suh, Howard Hurtig, Daniel Weintraub, Vivianna Van Deerlin, Edward B. Lee, John Q. Trojanowski, Alice S. Chen-Plotkin
Post-mortem analyses of PiB and flutemetamol in diffuse and cored amyloid-β plaques in Alzheimer’s disease
Milos D. Ikonomovic, Christopher J. Buckley, Eric E. Abrahamson, Julia K. Kofler, Chester A. Mathis, William E. Klunk, Gill Farrar
APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer’s disease
Aivi T. Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A. Azevedo, EunRan Suh, Vivianna M. Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B. Lee
Characterizing tau deposition in chronic traumatic encephalopathy (CTE): utility of the McKee CTE staging scheme
Michael L. Alosco, Jonathan D. Cherry, Bertrand Russell Huber, Yorghos Tripodis, Zachary Baucom, Neil W. Kowall, Nicole Saltiel, Lee E. Goldstein, Douglas I. Katz, Brigid Dwyer, Daniel H. Daneshvar, Joseph N. Palmisano, Brett Martin, Robert C. Cantu, Robert A. Stern, Victor E. Alvarez, Jesse Mez, Thor D. Stein, Ann C. McKee
TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis
Francesca Cignarella, Fabia Filipello, Bryan Bollman, Claudia Cantoni, Alberto Locca, Robert Mikesell, Melissa Manis, Adiljan Ibrahim, Li Deng, Bruno A. Benitez, Carlos Cruchaga, Danilo Licastro, Kathie Mihindukulasuriya, Oscar Harari, Michael Buckland, David M. Holtzman, Arnon Rosenthal, Tina Schwabe, Ilaria Tassi, Laura Piccio
Inhibition of Bruton’s tyrosine kinase interferes with pathogenic B-cell development in inflammatory CNS demyelinating disease
Sebastian Torke, Roxanne Pretzsch, Darius Häusler, Philipp Haselmayer, Roland Grenningloh, Ursula Boschert, Wolfgang Brück, Martin S. Weber
Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood–brain barrier
Judith Hauptmann, Lisa Johann, Federico Marini, Maja Kitic, Elisa Colombo, Ilgiz A. Mufazalov, Martin Krueger, Khalad Karram, Sonja Moos, Florian Wanke, Florian C. Kurschus, Matthias Klein, Silvia Cardoso, Judith Strauß, Subhashini Bolisetty, Fred Lühder, Markus Schwaninger, Harald Binder, Ingo Bechman, Tobias Bopp, Anupam Agarwal, Miguel P. Soares, Tommy Regen, Ari Waisman
Infratentorial IDH-mutant astrocytoma is a distinct subtype
Rouzbeh Banan, Damian Stichel, Anja Bleck, Bujung Hong, Ulrich Lehmann, Abigail Suwala, Annekathrin Reinhardt, Daniel Schrimpf, Rolf Buslei, Christine Stadelmann, Karoline Ehlert, Marco Prinz, Till Acker, Jens Schittenhelm, David Kaul, Leonille Schweizer, David Capper, Patrick N. Harter, Nima Etminan, David T. W. Jones, Stefan M. Pfister, Christel Herold-Mende, Wolfgang Wick, Felix Sahm, Andreas von Deimling, Christian Hartmann, David E. Reuss
Correlates of critical illness-related encephalopathy predominate postmortem COVID-19 neuropathology
Nikolaus Deigendesch, Lara Sironi, Michael Kutza, Sven Wischnewski, Vidmante Fuchs, Jürgen Hench, Angela Frank, Ronny Nienhold, Kirsten D. Mertz, Gieri Cathomas, Matthias S. Matter, Martin Siegemund, Markus Tolnay, Lucas Schirmer, Anne-Katrin Pröbstel, Alexandar Tzankov, Stephan Frank
Brain pathologies are associated with both the rate and variability of declining motor function in older adults
Aron S. Buchman, Tianhao Wang, Lei Yu, Sue E. Leurgans, Julie A. Schneider, David A. Bennett
Thorn-shaped astrocytes in the depth of cortical sulci in Western Pacific ALS/Parkinsonism-Dementia complex
Gabor G. Kovacs, John L. Robinson, Daniel P. Perl, Virginia M.-Y. Lee, John Q. Trojanowski
WNT-activated embryonal tumors of the pineal region: ectopic medulloblastomas or a novel pineoblastoma subgroup?
Anthony P. Y. Liu, Loudy P. Priesterbach-Ackley, Brent A. Orr, Bryan K. Li, Brian Gudenas, Roel E. Reddingius, Mariona Suñol, Cinzia E. Lavarino, Nagore G. Olaciregui, Vicente Santa-María López, Michael J. Fisher, Lili-Naz Hazrati, Eric Bouffet, Annie Huang, Giles W. Robinson, Pieter Wesseling, Paul A. Northcott, Amar Gajjar