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Cancer and Metastasis Reviews
Published in: Cancer and Metastasis Reviews 2/2008

01-06-2008

PTP1B and TC-PTP: regulators of transformation and tumorigenesis

Authors: Matthew Stuible, Karen M. Doody, Michel L. Tremblay

Published in: Cancer and Metastasis Reviews | Issue 2/2008

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Abstract

PTP1B and T cell PTP (TC-PTP) are protein tyrosine phosphatases (PTPs) that share high sequence and structural homology yet play distinct physiological roles. While PTP1B plays a central role in metabolism and is an attractive drug target for obesity and type 2 diabetes, TC-PTP is necessary for the control of inflammation. In this review, we will discuss the growing evidence for the involvement of PTP1B in cancer, while proposing a role for TC-PTP in inflammation-induced tumorigenesis. Given the challenge of developing inhibitors specific for PTP1B alone, it is necessary to consider both enzymes and their roles in various cancer models.
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Metadata
Title
PTP1B and TC-PTP: regulators of transformation and tumorigenesis
Authors
Matthew Stuible
Karen M. Doody
Michel L. Tremblay
Publication date
01-06-2008
Publisher
Springer US
Published in
Cancer and Metastasis Reviews / Issue 2/2008
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-008-9115-1

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