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Published in:

01-06-2007

The Risk of Cancer in Patients with Crohn’s Disease

Authors: Alexander C. von Roon, M.R.C.S., George Reese, M.R.C.S., Julian Teare, F.R.C.P., Vasilis Constantinides, M.B.B.S., Ara W. Darzi, F.Med.Sci., Paris P. Tekkis, M.D., F.R.C.S.

Published in: Diseases of the Colon & Rectum | Issue 6/2007

Purpose

The risk of cancer in patients with Crohn’s disease is not well defined. Using meta-analytical techniques, the present study was designed to quantify the risk of intestinal, extraintestinal, and hemopoietic malignancies in such patients.

Methods

A literature search identified 34 studies of 60,122 patients with Crohn’s disease. The incidence and relative risk of cancer were calculated for patients with Crohn’s disease and compared with the baseline population of patients without Crohn’s disease. Overall pooled estimates, with 95 percent confidence intervals, were obtained, using a random-effects model.

Results

The relative risk of small bowel, colorectal, extraintestinal cancer, and lymphoma compared with the baseline population was 28.4 (95 percent confidence interval, 14.46–55.66), 2.4 (95 percent confidence interval, 1.56–4.36), 1.27 (95 percent confidence interval, 1.1–1.47), and 1.42 (95 percent confidence interval, 1.16–1.73), respectively. On subgroup analysis, patients with Crohn’s disease had an increased risk of colon cancer (relative risk, 2.59; 95 percent confidence interval, 1.54–4.36) but not of rectal cancer (relative risk, 1.46; 95 percent confidence interval, 0.8–2.55). There was significant association between the anatomic location of the diseased bowel and the risk of cancer in that segment. The risk of small bowel cancer and colorectal cancer was found to be higher in North America and the United Kingdom than in Scandinavian countries with no evidence of temporal changes in the cancer incidence.

Conclusions

The present meta-analysis demonstrated an increased risk of small bowel, colon, extraintestinal cancers, and lymphoma in patients with Crohn’s disease. Patients with extensive colonic disease that has been present from a young age should be candidates for endoscopic surveillance; however, further data are required to evaluate the risk of neoplasia over time.

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Warren, S, Sommers, SC 1948Cicatrizing enteritis (regional enteritis) as a pathologic entity: analysis of one hundred and twenty casesAm J Pathol24475501PubMed

Eaden, JA, Abrams, KR, Mayberry, JF 2001The risk of colorectal cancer in ulcerative colitis: a meta-analysisGut48526535PubMed

Ginzburg, L, Schneider, K, Dreizin, D, Levinson, C 1956Carcinoma of the jejunum occurring in a case of regional enteritisSurgery39347351PubMed

Bersack, S, Howe, J, Rehak, E 1958A unique case of roentgenologic evidence of regional enteritis of long duration and histologic evidence of diffuse adenocarcinomaGastroenterology34703710PubMed

Buchanan, D, Huebner, S, Woolvin, R, North, R, Novack, T 1959Carcinoma of the ileum occurring in an area of regional enteritisAm J Surg97336339PubMed

Zisk, J, Shore, J, Rosoff, L, Friedman, N 1960Regional ileitis complicated by adenocarcinoma of the ileum: a report of two casesSurgery47970974PubMed

Hoffert, P, Weingarten, L, Friedman, L, Morecki, R 1963Adenocarcinoma of the terminal ileum in a segment of bowel with coexisting active enteritisN J Med6315671571

Berman, L, Prior, J 1964Adenocarcinoma of the small intestine occurring in a case of regional enteritisJ Mt Sinai Hosp N Y313037PubMed

Cantwell, J, Kettering, R, Carney, J, Ludwig, J 1968Adenocarcinoma complicating regional enteritis: report of a case and review of the literatureGastroenterology54599604PubMed

10.

Weedon, DD, Shorter, RG, Ilstrup, DM, Huizenga, KA, Taylor, WF 1973Crohn’s disease and cancerN Engl J Med28910991103PubMedCrossRef

11.

Persson, PG, Karlen, P, Bernell, O, et al. 1994Crohn’s disease and cancer: a population-based cohort studyGastroenterology10716751679PubMed

12.

Greenstein, AJ, Sachar, DB, Smith, H, Janowitz, HD, Aufses, AH,Jr 1981A comparison of cancer risk in Crohn’s disease and ulcerative colitisCancer4827422745PubMed

13.

Stroup, DF, Berlin, JA, Morton, SC, et al. 2000Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) groupJAMA28320082012PubMed

14.

Athanasiou, T, Al-Ruzzeh, S, Kumar, P, et al. 2004Off-pump myocardial revascularization is associated with less incidence of stroke in elderly patientsAnn Thorac Surg77745753PubMed

15.

Sharp, SJ, Sterne, JA 1997Meta-AnalysisStata Tech Bull38914

16.

Sharp, SJ 1998Meta-analysis regressionStata Tech Bull421622

17.

Collett, D 1993Modelling survival data in medical researchCRC Press LLCLondon

18.

Kyle, J, Ewen, SW 1992Two types of colorectal carcinoma in Crohn’s diseaseAnn R Coll Surg Engl74387390PubMed

19.

Bansal, P, Sonnenberg, A 1996Risk factors of colorectal cancer in inflammatory bowel diseaseAm J Gastroenterol914448PubMed

20.

Haldane, JB 1956The estimation and significance of the logarithm of a ratio of frequenciesAnn Hum Genet20309311PubMed

21.

Fleiss, JL 1993The statistical basis of meta-analysisStat Methods Med Res2121145PubMed

22.

Mantel, N, Haenszel, W 1959Statistical aspects of the analysis of data from retrospective studies of diseaseJ Natl Cancer Inst22719748PubMed

23.

Jess, T, Gamborg, M, Matzen, P, Munkholm, P, Sorensen, TI 2005Increased risk of intestinal cancer in Crohn’s disease: a meta-analysis of population-based cohort studiesAm J Gastroenterol10027242729PubMed

24.

Korelitz, BI 1983Carcinoma of the intestinal tract in Crohn’s disease: results of a survey conducted by the National Foundation for Ileitis and ColitisAm J Gastroenterol784446PubMed

25.

Yamazaki, Y, Ribeiro, MB, Sachar, DB, Aufses, AH,Jr, Greenstein, AJ 1991Malignant colorectal strictures in Crohn’s diseaseAm J Gastroenterol86882885PubMed

26.

Jacobsen, CD, Skjoto, J, Pytte, R, Lygren, I 1994Follow-up of chronic inflammatory bowel disease. A 10-year materialTidsskr Nor Laegeforen114674677PubMed

27.

Softley, A, Clamp, SE, Watkinson, G, Bouchier, IA, Myren, J, Dombal, FT 1988The natural history of inflammatory bowel disease: has there been a change in the last 20 years?Scand J Gastroenterol Suppl1442023PubMed

28.

Myren, J, Bouchier, IA, Watkinson, G, Softley, A, Clamp, SE, Dombal, FT 1988The OMGE multinational inflammatory bowel disease survey 1976–1986. A further report on 3175 casesScand J Gastroenterol Suppl1441119PubMed

29.

Freeman, HJ 2003Natural history and clinical behavior of Crohn’s disease extending beyond two decadesJ Clin Gastroenterol37216219PubMed

30.

Puntis, J, McNeish, AS, Allan, RN 1984Long term prognosis of Crohn’s disease with onset in childhood and adolescenceGut25329336PubMed

31.

Andrews, HA, Lewis, P, Allan, RN 1989Prognosis after surgery for colonic Crohn’s diseaseBr J Surg7611841190PubMed

32.

Freeman, HJ 2004Comparison of longstanding pediatric-onset and adult-onset Crohn’s diseaseJ Pediatr Gastroenterol Nutr39183186PubMed

33.

Al-Ghamdi, AS, Al-Mofleh, IA, Al-Rashed, RS, et al. 2004Epidemiology and outcome of Crohn’s disease in a teaching hospital in RiyadhWorld J Gastroenterol1013411344PubMed

34.

Morpurgo, E, Petras, R, Kimberling, J, Ziegler, C, Galandiuk, S 2003Characterization and clinical behavior of Crohn’s disease initially presenting predominantly as colitisDis Colon Rectum46918924PubMed

35.

Lapidus, A, Bernell, O, Hellers, G, Lofberg, A 1998Clinical course of colorectal Crohn’s disease: a 35-year follow-up study of 507 patientsGastroenterology11411511160PubMed

36.

Maeda, K, Okada, M, Yao, T, et al. 1994Intestinal and extraintestinal complications of Crohn’s disease: predictors and cumulative probability of complicationsJ Gastroenterol29577582PubMed

37.

Nakahara, T, Yao, T, Sakurai, T, et al. 1991Long-term prognosis of Crohn’s diseaseNippon Shokakibyo Gakkai Zasshi8813051312PubMed

38.

Barton, JR, Ferguson, A 1990Clinical features, morbidity and mortality of Scottish children with inflammatory bowel diseaseQ J Med75423439PubMed

39.

Freeman, HJ 2001Colorectal cancer complicating Crohn’s diseaseCan J Gastroenterol15231236PubMed

40.

Munkholm, P 1997Crohn’s disease: occurrence, course and prognosis. An epidemiologic cohort studyDan Med Bull44287302PubMed

41.

Munkholm, P, Langholz, E, Davidsen, M, Binder, V 1993Intestinal cancer risk and mortality in patients with Crohn’s diseaseGastroenterology10517161723PubMed

42.

Binder, V 1988Epidemiology, course and socio-economic influence of inflammatory bowel diseaseSchweiz Med Wochenschr118738742PubMed

43.

Cooke, WT, Mallas, E, Prior, P, Allan, RN 1980Crohn’s disease: course, treatment and long term prognosisQ J Med49363384PubMed

44.

Binder, V, Hendriksen, C, Kreiner, S 1985Prognosis in Crohn’s disease: based on results from a regional patient group from the county of CopenhagenGut26146150PubMed

45.

Greenstein, AJ, Sachar, DB, Smith, H, Janowitz, HD, Aufses, AH,Jr 1980Patterns of neoplasia in Crohn’s disease and ulcerative colitisCancer46403407PubMed

46.

Gillen, CD, Walmsley, RS, Prior, P, Andrews, HA, Allan, RN 1994Ulcerative colitis and Crohn’s disease: a comparison of the colorectal cancer risk in extensive colitisGut3515901592PubMed

47.

Binder V. Incidence of colonic cancer in inflammatory bowel disease. Scand J Gastroenterol Suppl 1989;170:78–82

48.

Jess, T, Loftus, E, Velayos, F, et al. 2005Increased risk of intestinal cancer in Crohn’s disease but not in ulcerative colitis: a population-based cohort study from Olmsted County, Minnesota, 1940–2002 [abstract]Gastroenterology128A321

49.

Fielding, JF, Prior, P, Waterhouse, JA, Cooke, WT 1972Malignancy in Crohn’s diseaseScand J Gastroenterol737PubMedCrossRef

50.

Farmer, RG, Hawk, WA, Turnbull, RB,Jr 1975Clinical patterns in Crohn’s disease: a statistical study of 615 casesGastroenterology68627635PubMed

51.

Atwell, JD, Duthie, HL, Goligher, JC 1965The outcome of Crohn’s diseaseBr J Surg52966972PubMed

52.

Crohn, BB, Yarnis, H 1966Granulomatous colitis: an attempt at clarificationJ Mt Sinai Hosp N Y33503513PubMed

53.

Cornes, JS, Stecher, M 1961Primary Crohn’s disease of the colon and rectumGut2189201PubMed

54.

Howel Jones, J, Lennard-Jones, J, Lockhart-Mummery, H 1966Experience in the treatment of Crohn’s disease of the large intestineGut7448452

55.

Hawk, WA, Turnbull, RB,Jr 1966Primary ulcerative disease of the colonGastroenterology51802805PubMed

56.

Lewis, JD, Bilker, WB, Brensinger, C, Deren, JJ, Vaughn, DJ, Strom, BL 2001Inflammatory bowel disease is not associated with an increased risk of lymphomaGastroenterology12110801087PubMed

57.

Gillen, CD, Andrews, HA, Prior, P, Allan, RN 1994Crohn’s disease and colorectal cancerGut35651655PubMed

58.

Mellemkjaer, L, Johansen, C, Gridley, G, Linet, MS, Kjaer, SK, Olsen, JH 2000Crohn’s disease and cancer risk (Denmark)Cancer Causes Control11145150PubMed

59.

Katsanos, KH, Christodoulou, DK, Michael, M, et al. 2005Inflammatory bowel disease-related dysplasia and cancer: a referral center study in northwestern GreeceEur J Intern Med16170175PubMed

60.

Fireman, Z, Grossman, A, Lilos, P, et al. 1989Intestinal cancer in patients with Crohn’s disease. A population study in central IsraelScand J Gastroenterol24346350PubMed

61.

Jess, T, Winther, KV, Munkholm, P, Langholz, E, Binder, V 2004Intestial and extra-intestinal cancer in Crohn’s disease: follow-up of a population-based cohort in Copenhagen County, DenmarkAliment Pharmacol Ther19287293PubMed

62.

Etienney, I, Bouhnik, Y, Gendre, JP, et al. 2004Crohn’s disease over 20 years after diagnosis in a referral populationGastroenterol Clin Biol2812331239PubMedCrossRef

63.

Freeman, HJ 2002Tabulation of myeloid, lymphoid and intestinal malignancies in Crohn’s diseaseCan J Gastroenterol16779784PubMed

64.

Bernstein, CN, Blanchard, JF, Kliewer, E, Wajda, A 2001Cancer risk in patients with inflammatory bowel disease: a population-based studyCancer91854862PubMed

65.

Frisch, M, Johansen, C 2000Anal carcinoma in inflammatory bowel diseaseBr J Cancer838990PubMed

66.

Triantafillidis, JK, Emmanouilidis, A, Manousos, O, Nicolakis, D, Kogevinas, M 2000Clinical patterns of Crohn’s disease in Greece: a follow-up study of 155 casesDigestion61121128PubMed

67.

Vannozzi, G, Fontana, R, Milla, M, et al. 1997Disease history in 382 Italian patients with Crohn’s diseaseItal J Gastroenterol Hepatol29525532PubMed

68.

Oriuchi, T, Hiwatashi, N, Kinouchi, Y, et al. 2003Clinical course and long-term prognosis of Japanese patients with Crohn’s disease: predictive factors, rates of operation, and mortalityJ Gastroenterol38942953PubMed

69.

Choi, PM, Zelig, MP 1994Similarity of colorectal cancer in Crohn’s disease and ulcerative colitis: implications for carcinogenesis and preventionGut35950954PubMed

70.

Ekbom, A, Helmick, C, Zack, M, Adami, O 1991Extracolonic malignancies in inflammatory bowel diseaseCancer6720152019PubMed

71.

Ekbom, A, Helmick, C, Zack, M, Adami, O 1990Increased risk of large-bowel cancer in Crohn’s disease with colonic involvementLancet336357359PubMed

72.

O’Keefe, EA, Wright, JP, Froggatt, J, Zabow, D 1989Medium-term follow-up of Crohn’s disease in Cape TownS Afr Med J76139141PubMed

73.

Gollop, JH, Phillips, SF, Melton, LJ,3rd, Zinsmeister, AR 1988Epidemiologic aspects of Crohn’s disease: a population based study in Olmsted County, Minnesota, 1943–1982Gut294956PubMed

74.

Andrews, JM, Norton, I, Dent, O, Goulston, K 1995Inflammatory bowel disease: a retrospective review of a specialist-based cohortMed J Aust163133136PubMed

75.

Harper, PH, Fazio, VW, Lavery, IC, et al. 1987The long-term outcome in Crohn’s diseaseDis Colon Rectum30174179PubMed

76.

Kvist, N, Jacobsen, O, Norgaard, P, et al. 1986Malignancy in Crohn’s diseaseScand J Gastroenterol218286PubMed

77.

Farmer, RG, Whelan, G, Fazio, VW 1985Long-term follow-up of patients with Crohn’s disease. Relationship between the clinical pattern and prognosisGastroenterology8818181825PubMed

78.

Gyde, SN, Prior, P, Macartney, JC, Thompson, H, Waterhouse, JA, Allan, RN 1980Malignancy in Crohn’s diseaseGut2110241029PubMed

79.

Truelove, SC, Pena, AS 1976Course and prognosis of Crohn’s diseaseGut17192201PubMed

80.

Lindgren, A, Wallerstedt, S, Olsson, R 1996Prevalence of Crohn’s disease and simultaneous occurrence of extraintestinal complications and cancer. An epidemiologic study in adultsScand J Gastroenterol317478PubMed

81.

Askling, J, Brandt, L, Lapidus, A, et al. 2005Risk of haematopoietic cancer in patients with inflammatory bowel diseaseGut54617622PubMed

82.

Arseneau, KO, Stukenborg, GJ, Connors, AF,Jr, Cominelli, F 2001The incidence of lymphoid and myeloid malignancies among hospitalized Crohn’s disease patientsInflamm Bowel Dis7106112PubMed

83.

Loftus, EV,Jr, Tremaine, WJ, Habermann, TM, Harmsen, WS, Zinsmeister, AR, Sandborn, WJ 2000Risk of lymphoma in inflammatory bowel diseaseAm J Gastroenterol9523082312PubMed

84.

Itzkowitz, SH, Yio, X 2004Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammationAm J Physiol Gastrointest Liver Physiol287G7G17PubMed

85.

Sachar, DB 1994Cancer in Crohn’s disease: dispelling the mythsGut3515071508PubMed

86.

UK Office of National Statistics. Cancer incidence and mortality in the United Kingdom 2001–2003. HMSO, 2005

87.

Greenstein, AJ, Gennuso, R, Sachar, DB, et al. 1985Extraintestinal cancers in inflammatory bowel diseaseCancer5629142921PubMed

88.

Losco, A, Gianelli, U, Cassani, B, Baldini, L, Cont, D, Basilisco, G 2004Epstein-Barr virus-associated lymphoma in Crohn’s diseaseInflamm Bowel Dis10425429PubMed

89.

Garcia-Sanchez, M, Poyato-Gonzalez, A, Giraldez-Jimenez, M, et al. 2006MALT lymphoma in a patient with Crohn’s disease. A causal or incidental association?Gastroenterol Hepatol297476PubMed

90.

Juffermans, NP, Jager, A, Kersten, MJ, Oers, MH, Hommes, DW 2005Epstein-Barr virus-related lymphomas in patients with inflammatory bowel diseaseNed Tijdschr Geneeskd14918591863PubMed

91.

Thayu, M, Markowitz, JE, Mamula, P, Russo, PA, Muinos, WI, Baldassano, RN 2005Hepatosplenic T-cell lymphoma in an adolescent patient after immunomodulator and biologic therapy for Crohn diseaseJ Pediatr Gastroenterol Nutr40220222PubMed

92.

Calvo-Villas, JM, Ramirez Sanchez, MJ, Cuesta Tovar, J, Garcia, C 2003Extraintestinal Hodgkin’s disease in a patient with Crohn’s diseaseSouth Med J96632PubMed

93.

Hall, CH,Jr, Shamma, M 2003Primary intestinal lymphoma complicating Crohn’s diseaseJ Clin Gastroenterol36332336PubMed

94.

Sivarajasingham, N, Adams, SA, Smith, ME, Hosie, KB 2003Perianal Hodgkin’s lymphoma complicating Crohn’s diseaseInt J Colorectal Dis18174176PubMed

95.

Martinez Tirado, P, Redondo Cerezo, E, Gonzalez Aranda, Y, Cabello Tapia, M 2001Ki-lymphoma of the skin in a patient with Crohn’s Disease undergoing treatment with azathioprineGastroenterol Hepatol25271272

96.

Li, S, Borowitz, MJ 2001Primary Epstein-Barr virus-associated Hodgkin disease of the ileum complicating Crohn diseaseArch Pathol Lab Med125424427PubMed

97.

Musso, M, Porretto, F, Crescimanno, A, Bondi, F, Polizzi, V, Scalone, R 2000Crohn’s disease complicated by relapsed extranodal Hodgkin’s lymphoma: prolonged complete remission after unmanipulated PBPC autotransplantBone Marrow Transplant26921923PubMed

98.

Bickston, SJ, Lichtenstein, GR, Arseneau, KO, Cohen, RB, Cominelli, F 1999The relationship between infliximab treatment and lymphoma in Crohn’s diseaseGastroenterology11714331437PubMed

99.

Korelitz, BI, Mirsky, FJ, Fleisher, MR, Warman, JI, Wisch, N, Gleim, GW 1999Malignant neoplasms subsequent to treatment of inflammatory bowel disease with 6-mercaptopurineAm J Gastroenterol9432483253PubMed

100.

Parasher, G, Jaswal, S, Golbey, S, Grinberg, M, Iswara, K 1999Extraintestinal non-Hodgkin’s lymphoma presenting as obstructive jaundice in a patient with Crohn’s diseaseAm J Gastroenterol94226228PubMed

101.

Kashyap, A, Forman, SJ 1998Autologous bone marrow transplantation for non-Hodgkin’s lymphoma resulting in long-term remission of coincidental Crohn’s diseaseBr J Haematol103651652PubMed

102.

Charlotte, F, Sriha, B, Mansour, G, Gabarre, J 1998An unusual case associating ileal Crohn’s disease and diffuse large B-cell lymphoma of an adjacent mesenteric lymph nodeArch Pathol Lab Med122559561PubMed

103.

Woodley, HE, Spencer, JA, MacLennan, KA 1997Small-bowel lymphoma complicating long-standing Crohn’s diseaseAJR Am J Roentgenol16914621463PubMed

104.

Kelly, MD, Stuart, M, Tschuchnigg, M, Turner, J, Tydd, T 1997Primary intestinal Hodgkin’s disease complicating ileal Crohn’s diseaseANZ J Surg67485489

105.

Veldman, W, Beek, M, Keuning, JJ, Driessen, WM 1996Regional enteritis complicating malignant lymphomaNeth J Med498285PubMed

106.

Larvol, L, Soule, JC, Tourneau, A 1994Reversible lymphoma in the setting of azathioprine therapy for Crohn’s diseaseN Engl J Med331883884PubMed

107.

Vanbockrijck, M, Cabooter, M, Casselman, J, Vanvuchelen, J, Hoof, A, Michielssen, P 1993Primary Hodgkin disease of the ileum complicating Crohn’s diseaseCancer7217841789PubMed

108.

Vazquez, C, Desaive, C 1993Malignant lymphoma complicating Crohn’s disease of the ileum. Apropos of a caseJ Chir (Paris)130364366

109.

Maaravi, Y, Wengrower, D, Leibowitz, G 1993A unique presentation of lymphoma of the colonJ Clin Gastroenterol174951PubMed

110.

Brown, I, Schofield, JB, MacLennan, KA, Tagart, RE 1992Primary non-Hodgkin’s lymphoma in ileal Crohn’s diseaseEur J Surg Oncol18627631PubMed

111.

Perosio, PM, Brooks, JJ, Saul, SH, Haller, DG 1992Primary intestinal lymphoma in Crohn’s disease: minute tumor with a fatal outcomeAm J Gastroenterol87894898PubMed

112.

Greenstein, AJ, Mullin, GE, Strauchen, JA, et al. 1992Lymphoma in inflammatory bowel diseaseCancer6911191123PubMedCrossRef

113.

Farrell, RJ, Ang, Y, Kileen, P, et al. 2000Increased incidence of non-Hodgkin’s lymphoma in inflammatory bowel disease patients on immunosuppressive therapy but overall risk is lowGut47514519PubMed

114.

Bouhnik, Y, Lemann, M, Mary, JY, et al. 1996Long-term follow-up of patients with Crohn’s disease treated with azathioprine or 6-mercaptopurineLancet347215219PubMed

115.

Caspi, O, Polliack, A, Klar, R, Ben-Yehuda, D 1995The association of inflammatory bowel disease and leukemia-coincidence or not?Leuk Lymphoma17255262PubMed

116.

Moody, GA, Jayanthi, V, Probert, CS, Mac Kay, H, Mayberry, JF 1996Long-term therapy with sulphasalazine protects against colorectal cancer in ulcerative colitis: a retrospective study of colorectal cancer risk and compliance with treatment in LeicestershireEur J Gastroenterol Hepatol811791183PubMed

117.

Eaden, J, Abrams, K, Ekbom, A, Jackson, E, Mayberry, J 2000Colorectal cancer prevention in ulcerative colitis: a case-control studyAliment Pharmacol Ther14145153PubMed

118.

Pinczowski, D, Ekbom, A, Baron, J, et al. 1994Risk factors for colorectal cancer in patients with ulcerative colitis: a case-control studyGastroenterology107117120PubMed

119.

Staa, TP, Card, T, Logan, RF, Leufkens, HG 20055-Aminosalicylate use and colorectal cancer risk in inflammatory bowel disease: a large epidemiological studyGut5415731578PubMed

120.

Binder, V 2004Epidemiology of IBD during the twentieth century: an integrated viewBest Pract Res Clin Gastroenterol18463479PubMed

121.

Srinivasan, R, Lewis, JD 2003Malignancies in inflammatory bowel diseaseCurr Opin Gastroenterol19366370PubMed

122.

Krok, KL, Lichtenstein, GR 2004Colorectal cancer in inflammatory bowel diseaseCurr Opin Gastroenterol204348PubMed

123.

Sharan, R, Schoen, RE 2002Cancer in inflammatory bowel disease. An evidence-based analysis and guide for physicians and patientsGastroenterol Clin North Am31237254PubMed

124.

Ullman TA. Dysplasia and colorectal cancer in Crohn’s disease. J Clin Gastroenterol 2003;36(Suppl 5):S75–78–96

125.

van Hogezand RA, Eichhorn RF, Choudry A, Veenendal RA, Lamers CB. Malignancies in inflammatory bowel disease: fact or fiction? Scand J Gastroenterol 2002;(Suppl 236):48–53

126.

Munkholm, P 2003Review article: the incidence and prevalence of colorectal cancer in inflammatory bowel diseaseAliment Pharmacol Ther1815PubMed

127.

Greenstein, AJ 2000Cancer in inflammatory bowel diseaseMt Sinai J Med67227240PubMed

128.

Tsianos, EV 2000Risk of cancer in inflammatory bowel disease (IBD)Eur J Intern Med117578PubMed

129.

Bernstein, D, Rogers, A 1996Malignancy in Crohn’s diseaseAm J Gastroenterol91434440PubMed

130.

Sjodahl, RI, Myrelid, P, Soderholm, JD 2003Anal and rectal cancer in Crohn’s diseaseColorectal Dis5490495PubMed

131.

Schlesselman, JJ 1997Risk of endometrial cancer in relation to use of combined oral contraceptives. A practitioner’s guide to meta-analysisHum Reprod1218511863PubMed

Title: The Risk of Cancer in Patients with Crohn’s Disease
Authors: Alexander C. von Roon, M.R.C.S.
George Reese, M.R.C.S.
Julian Teare, F.R.C.P.
Vasilis Constantinides, M.B.B.S.
Ara W. Darzi, F.Med.Sci.
Paris P. Tekkis, M.D., F.R.C.S.
Publication date: 01-06-2007
Publisher: Springer-Verlag
Published in: Diseases of the Colon & Rectum / Issue 6/2007
Print ISSN: 0012-3706
Electronic ISSN: 1530-0358
DOI: https://doi.org/10.1007/s10350-006-0848-z

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The Risk of Cancer in Patients with Crohn’s Disease

Purpose

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Conclusions

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