Skip to main content
Top
Published in: World Journal of Surgical Oncology 1/2008

Open Access 01-12-2008 | Case report

Paraneoplastic pemphigus regression after thymoma resection

Authors: Nikolaos Barbetakis, Georgios Samanidis, Dimitrios Paliouras, Ioannis Boukovinas, Christos Asteriou, Eleni Stergiou, Kostas Laschos, Christodoulos Tsilikas

Published in: World Journal of Surgical Oncology | Issue 1/2008

Login to get access

Abstract

Background

Among human neoplasms thymomas are associated with highest frequency with paraneoplastic autoimmune diseases.

Case presentation

A case of a 42-year-old woman with paraneoplastic pemphigus as the first manifestation of thymoma is reported. Transsternal complete thymoma resection achieved pemphigus regression. The clinical correlations between pemphigus and thymoma are presented.

Conclusion

Our case report provides further evidence for the important role of autoantibodies in the pathogenesis of paraneoplastic skin diseases in thymoma patients. It also documents the improvement of the associated pemphigus after radical treatment of the thymoma.
Appendix
Available only for authorised users
Literature
1.
go back to reference Bobbio A, Vescovi P, Ampollini L, Rusca M: Oral erosive lichen planus regression after thymona resection. Ann Thorac Surg. 2007, 83: 1197-1199. 10.1016/j.athoracsur.2006.08.024.CrossRefPubMed Bobbio A, Vescovi P, Ampollini L, Rusca M: Oral erosive lichen planus regression after thymona resection. Ann Thorac Surg. 2007, 83: 1197-1199. 10.1016/j.athoracsur.2006.08.024.CrossRefPubMed
2.
go back to reference Gibson LE, Muller SA: Dermatologic disorders in patients with thymoma. Acta Derm Venereol. 1987, 67: 351-356.PubMed Gibson LE, Muller SA: Dermatologic disorders in patients with thymoma. Acta Derm Venereol. 1987, 67: 351-356.PubMed
3.
go back to reference Hartz RS, Daroca PJ: Clinical-pathologic conference:cutaneous paraneoplastic pemphigus associated with benign encapsulated thymoma. J Thorac Cardiovasc Surg. 2003, 125: 400-406. 10.1067/mtc.2003.60.CrossRefPubMed Hartz RS, Daroca PJ: Clinical-pathologic conference:cutaneous paraneoplastic pemphigus associated with benign encapsulated thymoma. J Thorac Cardiovasc Surg. 2003, 125: 400-406. 10.1067/mtc.2003.60.CrossRefPubMed
4.
go back to reference Winkler DT, Strnad P, Meier ML, Roten S, Went P, Lyrer P, Steck AJ: Myasthenia gravis, paraneoplastic pemphigus and thymoma. A rare triad. J Neurol. 2007, 254 (11): 1601-1603. 10.1007/s00415-007-0588-6.CrossRefPubMed Winkler DT, Strnad P, Meier ML, Roten S, Went P, Lyrer P, Steck AJ: Myasthenia gravis, paraneoplastic pemphigus and thymoma. A rare triad. J Neurol. 2007, 254 (11): 1601-1603. 10.1007/s00415-007-0588-6.CrossRefPubMed
5.
go back to reference Meyer S, Kroiss M, Landthaler M, Vogt T: Thymoma, myasthenia gravis, eruptions of pemphigus vulgaris and a favourable course of relapsing melanoma: an immunological puzzle. Br J Dermatol. 2006, 155 (3): 638-640. 10.1111/j.1365-2133.2006.07384.x.CrossRefPubMed Meyer S, Kroiss M, Landthaler M, Vogt T: Thymoma, myasthenia gravis, eruptions of pemphigus vulgaris and a favourable course of relapsing melanoma: an immunological puzzle. Br J Dermatol. 2006, 155 (3): 638-640. 10.1111/j.1365-2133.2006.07384.x.CrossRefPubMed
6.
go back to reference Camisa C, Helm TN: Paraneoplastic pemphigus is a distinct neoplasia-induced autoimmune disease. Arch Dermatol. 1993, 129: 883-886. 10.1001/archderm.129.7.883.CrossRefPubMed Camisa C, Helm TN: Paraneoplastic pemphigus is a distinct neoplasia-induced autoimmune disease. Arch Dermatol. 1993, 129: 883-886. 10.1001/archderm.129.7.883.CrossRefPubMed
7.
go back to reference Proby C, Fujii Y, Owaribe K, Nishikawa T, Amagai M: Human autoantibodies against HD1/plectin in paraneoplastic pemphigus. J Invest Dermatol. 1999, 112 (2): 153-6. 10.1046/j.1523-1747.1999.00498.x.CrossRefPubMed Proby C, Fujii Y, Owaribe K, Nishikawa T, Amagai M: Human autoantibodies against HD1/plectin in paraneoplastic pemphigus. J Invest Dermatol. 1999, 112 (2): 153-6. 10.1046/j.1523-1747.1999.00498.x.CrossRefPubMed
8.
go back to reference Wang L, Bu D, Yang Y, Chen X, Zhu X: Castleman's tumor and production of autoantibody in paraneoplastic pemphigus. Lancet. 2004, 363: 525-531. 10.1016/S0140-6736(04)15539-6.CrossRefPubMed Wang L, Bu D, Yang Y, Chen X, Zhu X: Castleman's tumor and production of autoantibody in paraneoplastic pemphigus. Lancet. 2004, 363: 525-531. 10.1016/S0140-6736(04)15539-6.CrossRefPubMed
Metadata
Title
Paraneoplastic pemphigus regression after thymoma resection
Authors
Nikolaos Barbetakis
Georgios Samanidis
Dimitrios Paliouras
Ioannis Boukovinas
Christos Asteriou
Eleni Stergiou
Kostas Laschos
Christodoulos Tsilikas
Publication date
01-12-2008
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2008
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/1477-7819-6-83

Other articles of this Issue 1/2008

World Journal of Surgical Oncology 1/2008 Go to the issue