Skip to main content
Top
Published in: World Journal of Surgical Oncology 1/2008

Open Access 01-12-2008 | Case report

Pyoderma gangrenosum after totally implanted central venous access device insertion

Authors: Ihsan Inan, Patrick O Myers, Rolf Braun, Monica E Hagen, Philippe Morel

Published in: World Journal of Surgical Oncology | Issue 1/2008

Login to get access

Abstract

Background

Pyoderma gangrenosum is an aseptic skin disease. The ulcerative form of pyoderma gangrenosum is characterized by a rapidly progressing painful irregular and undermined bordered necrotic ulcer. The aetiology of pyoderma gangrenosum remains unclear. In about 70% of cases, it is associated with a systemic disorder, most often inflammatory bowel disease, haematological disease or arthritis. In 25–50% of cases, a triggering factor such as recent surgery or trauma is identified. Treatment consists of local and systemic approaches. Systemic steroids are generally used first. If the lesions are refractory, steroids are combined with other immunosuppressive therapy or to antimicrobial agents.

Case presentation

A 90 years old patient with myelodysplastic syndrome, seeking regular transfusions required totally implanted central venous access device (Port-a-Cath®) insertion. Fever and inflammatory skin reaction at the site of insertion developed on the seventh post-operative day, requiring the device's explanation. A rapid progression of the skin lesions evolved into a circular skin necrosis. Intravenous steroid treatment stopped the necrosis' progression.

Conclusion

Early diagnosis remains the most important step to the successful treatment of pyoderma gangrenosum.
Appendix
Available only for authorised users
Literature
1.
go back to reference Hachem R, Raad I: Prevention and management of long-term catheter related infections in cancer patients. Cancer Invest. 2002, 20: 1105-1113. 10.1081/CNV-120015984.CrossRefPubMed Hachem R, Raad I: Prevention and management of long-term catheter related infections in cancer patients. Cancer Invest. 2002, 20: 1105-1113. 10.1081/CNV-120015984.CrossRefPubMed
2.
go back to reference Reichrath J, Bens G, Bonowitz A, Tilgen W: Treatment recommendations for pyoderma gangrenosum: an evidence-based review of the literature based on more than 350 patients. J Am Acad Dermatol. 2005, 53: 273-283. 10.1016/j.jaad.2004.10.006.CrossRefPubMed Reichrath J, Bens G, Bonowitz A, Tilgen W: Treatment recommendations for pyoderma gangrenosum: an evidence-based review of the literature based on more than 350 patients. J Am Acad Dermatol. 2005, 53: 273-283. 10.1016/j.jaad.2004.10.006.CrossRefPubMed
3.
go back to reference Su WP, Davis MD, Weenig RH, Powell FC, Perry HO: Pyoderma gangrenosum: clinicopathologic correlation and proposed diagnostic criteria. Int J Dermatol. 2004, 43: 790-800. 10.1111/j.1365-4632.2004.02128.x.CrossRefPubMed Su WP, Davis MD, Weenig RH, Powell FC, Perry HO: Pyoderma gangrenosum: clinicopathologic correlation and proposed diagnostic criteria. Int J Dermatol. 2004, 43: 790-800. 10.1111/j.1365-4632.2004.02128.x.CrossRefPubMed
4.
go back to reference Cullen TS: A progressively enlarging ulcer of the abdominal wall involving skin and fat, following drainage of an abdominal abscess apparently from appendiceal origin. Surg Gynecol Obstet. 1924, 38: 579-582. Cullen TS: A progressively enlarging ulcer of the abdominal wall involving skin and fat, following drainage of an abdominal abscess apparently from appendiceal origin. Surg Gynecol Obstet. 1924, 38: 579-582.
5.
go back to reference Brunsting L, Goeckerman W, O'Leary P: Pyoderma gangrenosum: clinical and experimental observations in five cases occuring in adults. Arch Dermatol. 1930, 22: 655-680.CrossRef Brunsting L, Goeckerman W, O'Leary P: Pyoderma gangrenosum: clinical and experimental observations in five cases occuring in adults. Arch Dermatol. 1930, 22: 655-680.CrossRef
6.
go back to reference Oka M, Berking C, Nesbit M, Satyamoorthy K, Schaider H, Murphy G: Interleukin-8 overexpression is present in pyoderma gangrenosum ulcers and leads to ulcer formation in human skin xenografts. Lab Invest. 2000, 80: 595-604.CrossRefPubMed Oka M, Berking C, Nesbit M, Satyamoorthy K, Schaider H, Murphy G: Interleukin-8 overexpression is present in pyoderma gangrenosum ulcers and leads to ulcer formation in human skin xenografts. Lab Invest. 2000, 80: 595-604.CrossRefPubMed
7.
go back to reference Yeon HB, Lindor NM, Seidman JG, Seidman CE: Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome maps to chromosome 15q. Am J Hum Genet. 2000, 66: 1443-1448. 10.1086/302866.PubMedCentralCrossRefPubMed Yeon HB, Lindor NM, Seidman JG, Seidman CE: Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome maps to chromosome 15q. Am J Hum Genet. 2000, 66: 1443-1448. 10.1086/302866.PubMedCentralCrossRefPubMed
8.
go back to reference Weenig RH, Davis MD, Dahl PR, Su WP: Skin ulcers misdiagnosed as pyoderma gangrenosum. N Engl J Med. 2002, 347: 1412-1418. 10.1056/NEJMoa013383.CrossRefPubMed Weenig RH, Davis MD, Dahl PR, Su WP: Skin ulcers misdiagnosed as pyoderma gangrenosum. N Engl J Med. 2002, 347: 1412-1418. 10.1056/NEJMoa013383.CrossRefPubMed
9.
11.
go back to reference Bennett ML, Jackson JM, Jorizzo JL, Fleischer AB, White WL, Callen JP: Pyoderma gangrenosum. A comparison of typical and atypical forms with an emphasis on time to remission. Case review of 86 patients from 2 institutions. Medicine (Baltimore). 2000, 79: 37-46. 10.1097/00005792-200001000-00004.CrossRef Bennett ML, Jackson JM, Jorizzo JL, Fleischer AB, White WL, Callen JP: Pyoderma gangrenosum. A comparison of typical and atypical forms with an emphasis on time to remission. Case review of 86 patients from 2 institutions. Medicine (Baltimore). 2000, 79: 37-46. 10.1097/00005792-200001000-00004.CrossRef
12.
go back to reference Ehling A, Karrer S, Klebl F, Schaffler A, Muller-Ladner U: Therapeutic management of pyoderma gangrenosum. Arthritis Rheum. 2004, 50: 3076-3084. 10.1002/art.20559.CrossRefPubMed Ehling A, Karrer S, Klebl F, Schaffler A, Muller-Ladner U: Therapeutic management of pyoderma gangrenosum. Arthritis Rheum. 2004, 50: 3076-3084. 10.1002/art.20559.CrossRefPubMed
13.
go back to reference Patel GK, Rhodes JR, Evans B, Holt PJ: Successful treatment of pyoderma gangrenosum with topical 0.5% nicotine cream. J Dermatolog Treat. 2004, 15: 122-125. 10.1080/09546630310019364.CrossRefPubMed Patel GK, Rhodes JR, Evans B, Holt PJ: Successful treatment of pyoderma gangrenosum with topical 0.5% nicotine cream. J Dermatolog Treat. 2004, 15: 122-125. 10.1080/09546630310019364.CrossRefPubMed
Metadata
Title
Pyoderma gangrenosum after totally implanted central venous access device insertion
Authors
Ihsan Inan
Patrick O Myers
Rolf Braun
Monica E Hagen
Philippe Morel
Publication date
01-12-2008
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2008
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/1477-7819-6-31

Other articles of this Issue 1/2008

World Journal of Surgical Oncology 1/2008 Go to the issue