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Open Access 01-12-2008 | Case report

The Merendino procedure following preoperative imatinib mesylate for locally advanced gastrointestinal stromal tumor of the esophagogastric junction

Authors: Wilko I Staiger, Ulrich Ronellenfitsch, Georg Kaehler, Hans Ulrich Schildhaus, Antonia Dimitrakopoulou-Strauss, Matthias HM Schwarzbach, Peter Hohenberger

Published in: World Journal of Surgical Oncology | Issue 1/2008

Abstract

Background

Gastrointestinal stromal tumors (GIST) of the esophagogastric junction might pose a major problem to surgical resection. If locally advanced, extended or multivisceral resection with relevant procedural-specific morbidity and mortality is often necessary.

Case presentation

We report a case of a patient with a locally advanced GIST of the esophagogastric junction who was treated by transhiatal resection of the lower esophagus and gastric cardia with reconstruction by interposition of segment of the jejunum (Merendino procedure). Prior to resection, downsizing of the tumor had successfully been achieved by treatment with imatinib mesylate for six months. Histological proof of GIST by immunohistochemical expression of c-KIT and/or PDGF alpha Receptor is crucial to allow embarking on this treatment strategy.

Conclusion

A multimodal approach for an advanced GIST of the esophagogastric junction with preoperative administration of imatinib mesylate could avoid extended resection. The Merendino procedure might be considered as the reconstruction method of choice after resection of GIST at this location.

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Title: The Merendino procedure following preoperative imatinib mesylate for locally advanced gastrointestinal stromal tumor of the esophagogastric junction
Authors: Wilko I Staiger
Ulrich Ronellenfitsch
Georg Kaehler
Hans Ulrich Schildhaus
Antonia Dimitrakopoulou-Strauss
Matthias HM Schwarzbach
Peter Hohenberger
Publication date: 01-12-2008
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2008
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-6-37

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The Merendino procedure following preoperative imatinib mesylate for locally advanced gastrointestinal stromal tumor of the esophagogastric junction

Abstract

Background

Case presentation

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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