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Acta Diabetologica

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01-06-2019 | Obesity | Review Article

Spousal diabetes status as a risk factor for incident type 2 diabetes: a prospective cohort study and meta-analysis

Authors: Duke Appiah, Pamela J. Schreiner, Elizabeth Selvin, Ellen W. Demerath, James S. Pankow

Published in: Acta Diabetologica | Issue 6/2019

Abstract

Aims

It is unclear if the presence of type-2 diabetes in one spouse is associated with the development of diabetes in the other spouse. We studied the concordance of diabetes among black and white participants in the Atherosclerosis Risk in Communities (ARIC) study and summarized existing studies in a meta-analysis.

Methods

We conducted a prospective cohort analysis of ARIC data from 8077 married men and women (mean age 54 years) without diabetes at baseline (1987–1989). Complementary log–log models that accounted for interval censoring was used to model the hazard ratio (HR) for the association of spousal diabetes status with the incidence of diabetes. For the meta-analysis, we searched MEDLINE and EMBASE for observational studies published through December 2018 that evaluated spousal concordance for diabetes.

Results

During a median follow-up of 22 years, 2512 incident cases of diabetes were recorded. In models with adjustment for general adiposity, spousal cardiometabolic factors and other diabetes risk factors, adults who had a spouse with diabetes had elevated risk for incident diabetes compared to those without a spouse diagnosed with diabetes (HR 1.20, 95% confidence interval 1.02–1.41). This association did not differ by sex or race. Summarized estimates from the 17 studies (489,798 participants from 9 countries) included in the meta-analysis showed a positive association between spousal diabetes status and the development of diabetes (Pooled odds ratio 1.88, 95% CI 1.52–2.33).

Conclusions

Results from this large prospective biracial cohort and meta-analysis provides evidence that spouses of persons with diabetes are a high-risk group for diabetes.

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Title: Spousal diabetes status as a risk factor for incident type 2 diabetes: a prospective cohort study and meta-analysis
Authors: Duke Appiah
Pamela J. Schreiner
Elizabeth Selvin
Ellen W. Demerath
James S. Pankow
Publication date: 01-06-2019
Publisher: Springer Milan
Keywords: Obesity
Obesity
Type 2 Diabetes
Published in: Acta Diabetologica / Issue 6/2019
Print ISSN: 0940-5429
Electronic ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-019-01311-y

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