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Published in: Cancer and Metastasis Reviews 4/2023

20-11-2023 | Metastasis | REVIEW

Metastasis suppressor genes and their role in the tumor microenvironment

Authors: Cristina Megino-Luque, Jose Javier Bravo-Cordero

Published in: Cancer and Metastasis Reviews | Issue 4/2023

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Abstract

The metastatic cascade is a complex process with multiple factors contributing to the seeding and growth of cancer cells at metastatic sites. Within this complex process, several genes have been identified as metastasis suppressors, playing a role in the inhibition of metastasis. Interestingly, some of these genes have been shown to also play a role in regulating the tumor microenvironment. In this review, we comment on the recent developments in the biology of metastasis suppressor genes and their crosstalk with the microenvironment.
Literature
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go back to reference Ranganathan, A. C., Adam, A. P., Zhang, L., & Aguirre-Ghiso, J. A. (2006). Tumor cell dormancy induced by p38 SAPK and ER-stress signaling: An adaptive advantage for metastatic cells? Growth cessation and adaptation to stress as a selective advantage for multi-cellular organisms. Cancer Biology & Therapy, 5(7), 729–735.CrossRef Ranganathan, A. C., Adam, A. P., Zhang, L., & Aguirre-Ghiso, J. A. (2006). Tumor cell dormancy induced by p38 SAPK and ER-stress signaling: An adaptive advantage for metastatic cells? Growth cessation and adaptation to stress as a selective advantage for multi-cellular organisms. Cancer Biology & Therapy, 5(7), 729–735.CrossRef
Metadata
Title
Metastasis suppressor genes and their role in the tumor microenvironment
Authors
Cristina Megino-Luque
Jose Javier Bravo-Cordero
Publication date
20-11-2023
Publisher
Springer US
Keyword
Metastasis
Published in
Cancer and Metastasis Reviews / Issue 4/2023
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-023-10155-6

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