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20-11-2023 | Metastasis | REVIEW

Metastasis suppressor genes and their role in the tumor microenvironment

Authors: Cristina Megino-Luque, Jose Javier Bravo-Cordero

Published in: Cancer and Metastasis Reviews

Abstract

The metastatic cascade is a complex process with multiple factors contributing to the seeding and growth of cancer cells at metastatic sites. Within this complex process, several genes have been identified as metastasis suppressors, playing a role in the inhibition of metastasis. Interestingly, some of these genes have been shown to also play a role in regulating the tumor microenvironment. In this review, we comment on the recent developments in the biology of metastasis suppressor genes and their crosstalk with the microenvironment.

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Title: Metastasis suppressor genes and their role in the tumor microenvironment
Authors: Cristina Megino-Luque
Jose Javier Bravo-Cordero
Publication date: 20-11-2023
Publisher: Springer US
Keyword: Metastasis
Published in: Cancer and Metastasis Reviews
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-023-10155-6

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Oncology and Hematology Cases

45/♀ with increasing weakness, loss of appetite, diarrhoea and oedema – Case 29

48/♀ with increasing spontaneous haematomas all over her body – Case 37

49/♀ with lymphoedema of the arm in condition of metastasised triple-negative breast carcinoma – Case 43

53/♂ with movement-dependent pain in the left anterior pelvis and bloody urine – Case 39

Keynote Webinar | Spotlight on Diet and Diabetes

Springer Medicine

Abstract

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European Society for Medical Oncology Congress 2023

Test your knowledge with Case-Based Clinical Insights

Oncology and Hematology Cases