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Open Access 01-12-2021 | Septicemia | Review

Initial antimicrobial management of sepsis

Authors: Michael S. Niederman, Rebecca M. Baron, Lila Bouadma, Thierry Calandra, Nick Daneman, Jan DeWaele, Marin H. Kollef, Jeffrey Lipman, Girish B. Nair

Published in: Critical Care | Issue 1/2021

Abstract

Sepsis is a common consequence of infection, associated with a mortality rate > 25%. Although community-acquired sepsis is more common, hospital-acquired infection is more lethal. The most common site of infection is the lung, followed by abdominal infection, catheter-associated blood steam infection and urinary tract infection. Gram-negative sepsis is more common than gram-positive infection, but sepsis can also be due to fungal and viral pathogens. To reduce mortality, it is necessary to give immediate, empiric, broad-spectrum therapy to those with severe sepsis and/or shock, but this approach can drive antimicrobial overuse and resistance and should be accompanied by a commitment to de-escalation and antimicrobial stewardship. Biomarkers such a procalcitonin can provide decision support for antibiotic use, and may identify patients with a low likelihood of infection, and in some settings, can guide duration of antibiotic therapy. Sepsis can involve drug-resistant pathogens, and this often necessitates consideration of newer antimicrobial agents.

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Title: Initial antimicrobial management of sepsis
Authors: Michael S. Niederman
Rebecca M. Baron
Lila Bouadma
Thierry Calandra
Nick Daneman
Jan DeWaele
Marin H. Kollef
Jeffrey Lipman
Girish B. Nair
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Septicemia
Septicemia
Antibiotic
Pneumonia
Pseudomonas Aeruginosa
Biomarkers
Published in: Critical Care / Issue 1/2021
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-021-03736-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Initial antimicrobial management of sepsis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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