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World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2018

Open Access 01-12-2018 | Research

Evaluation of the expression and clinical value of lncRNA AC010761.9 in human gastric adenocarcinoma

Authors: Zhihua Wang, Kai Wang, Yuan Dang, Xiaojuan Ouyang, Fan Zhang, Wenyuan Wang, Lie Wang, Qiaojia Huang

Published in: World Journal of Surgical Oncology | Issue 1/2018

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Abstract

Background

The current study determined the expression and clinical value of lncRNA AC010761.9 in human gastric adenocarcinoma (GA).

Methods

Real-time quantitative reverse transcription (qRT)-PCR was used to detect the level of lncRNA expression in 145 GA tissues and three GA cell lines, and the correlation between its level and clinicopathologic characteristics and potential corresponding mRNA of TNF receptor-associated factor 4 gene (TRAF4) was then evaluated.

Results

Elevated lncRNA AC010761.9 was detected in all 6 GA tissues by previous lncRNA expression profile microarray assay. LncRNA AC010761.9 was over-expressed in 99 of 145 GA tissues (68.3%) with an elevated fold change of up to 35.14 compared to matched paracancerous tissues (p < 0.05), and was also over-expressed in the 3 GA cell lines (MGC803, BGC823, and SGC7901) compared to the normal gastric mucosal epithelial cell line (GES-1 cells; p < 0.05) by qRT-PCR. The elevated expression of this lncRNA was related to tumor size (p = 0.028), degree of differentiation (p = 0.047), and serum carbohydrate antigen (CA19-9) and carcinoembryonic antigen (CEA) concentrations (p = 0.026 and p = 0.037, respectively). Multivariate analysis further confirmed that the expression of lncRNA AC010761.9 was related to the degree of tumor differentiation (p = 0.015). Additionally, the expression of lncRNA AC010761.9 had a positive correlation with the mRNA expression of the potentially associated gene (TRAF4) in GA tissues (r = 0.385, p < 0.01).

Conclusions

LncRNA AC010761.9 may be linked to GA progression and is a potential new biomarker for GA.
Appendix
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Metadata
Title
Evaluation of the expression and clinical value of lncRNA AC010761.9 in human gastric adenocarcinoma
Authors
Zhihua Wang
Kai Wang
Yuan Dang
Xiaojuan Ouyang
Fan Zhang
Wenyuan Wang
Lie Wang
Qiaojia Huang
Publication date
01-12-2018
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2018
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/s12957-017-1289-y

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