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BMC Infectious Diseases

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Open Access 01-12-2021 | Tuberculosis | Research article

MPT64 assays for the rapid detection of Mycobacterium tuberculosis

Authors: Xun-Jie Cao, Ya-Ping Li, Jia-Ying Wang, Jie Zhou, Xu-Guang Guo

Published in: BMC Infectious Diseases | Issue 1/2021

Abstract

Background

Tuberculosis (TB) is a serious infectious disease caused by Mycobacterium tuberculosis (MTB). An estimated 1.7 billion people worldwide are infected with Mycobacterium tuberculosis (LTBI) during the incubation period without any obvious symptoms. Because of MTB’s high infection and mortality rates, there is an urgent need to develop a fast, portable, and sensitive diagnostic technology for its detection.

Methods

We included research from PubMed, Cochrane Library, Web of Science, and Embase and extracted the data. MetaDisc and STATA were used to build forest plots, Deek’s funnel plot, Fagan plot, and bivariate boxplot for analysis.

Results

Forty-six articles were analyzed, the results of which are as follows: sensitivity and specificity were 0.92 (0.91–0.93) and 0.95 (0.94–0.95) respectively. The NLR and PLR were 0.04 (95% CI 0.03–0.07) and 25.32 (95% CI 12.38–51.78) respectively. DOR was 639.60 (243.04–1683.18). The area under the SROC curve (AUC) was 0.99.

Conclusions

MPT64 exhibits good diagnostic efficiency for MTB. There is no obvious heterogeneity between the three commercial kits.

Available only for authorised users

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Title: MPT64 assays for the rapid detection of Mycobacterium tuberculosis
Authors: Xun-Jie Cao
Ya-Ping Li
Jia-Ying Wang
Jie Zhou
Xu-Guang Guo
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Tuberculosis
Mycobacterium Tuberculosis
Tuberculosis
Published in: BMC Infectious Diseases / Issue 1/2021
Electronic ISSN: 1471-2334
DOI: https://doi.org/10.1186/s12879-021-06022-w

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Abstract

Background

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