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Published in: BMC Infectious Diseases 1/2019

Open Access 01-12-2019 | Chloroquin | Case report

A case report of visceral leishmaniasis and malaria co-infection with pancytopenia and splenomegaly - a diagnostic challenge

Authors: Pragya Gautam Ghimire, Prasanna Ghimire, Jyoti Adhikari, Anurag Chapagain

Published in: BMC Infectious Diseases | Issue 1/2019

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Abstract

Background

Leishmaniasis and malaria are tropical diseases with more than half of the world population at risk of infection resulting in significant morbidity and mortality. Co-infection of Leishmaniasis and malaria pose a great challenge in the diagnosis as well as overall management.

Case presentation

In this case report, we present a rare case of a 5 years old child hailing from non-endemic region of Nepal with history of fever for a period of 3 months who was diagnosed as co-infection of malaria due to Plasmodium vivax and visceral Leishmaniasis with pancytopenia that subsequently improved after a course of treatment.

Conclusions

A high index of suspicion for a possibility of co-infection with Leishmaniasis and malaria should be borne in mind when an individual hailing from or having history of travel to endemic countries presents with prolonged fever.
Literature
1.
go back to reference Shrestha M, Pandey BD, Maharjan J, Dumre SP, Tiwari PN, Manandhar KD, et al. Visceral leishmaniasis from a non-endemic Himalayan region of Nepal. Parasitol Res. 2018;117(7):2323–6.CrossRef Shrestha M, Pandey BD, Maharjan J, Dumre SP, Tiwari PN, Manandhar KD, et al. Visceral leishmaniasis from a non-endemic Himalayan region of Nepal. Parasitol Res. 2018;117(7):2323–6.CrossRef
2.
go back to reference Ferede G, Diro E, Getie S, Getnet G, Takele Y, Amsalu A, et al. Visceral Leishmaniasis-malaria Coinfection and their associated factors in patients attending Metema hospital, Northwest Ethiopia: Suggestion for Integrated Vector Management. Malar Res Treat. 2017;2017:6816913.PubMedPubMedCentral Ferede G, Diro E, Getie S, Getnet G, Takele Y, Amsalu A, et al. Visceral Leishmaniasis-malaria Coinfection and their associated factors in patients attending Metema hospital, Northwest Ethiopia: Suggestion for Integrated Vector Management. Malar Res Treat. 2017;2017:6816913.PubMedPubMedCentral
3.
go back to reference Rijal KR, Adhikari B, Ghimire P, Banjara MR, Hanboonkunupakarn B, Imwong M, et al. Epidemiology of plasmodium vivax malaria infection in Nepal. Am J Trop Med Hyg. 2018;99(3):680–7.CrossRef Rijal KR, Adhikari B, Ghimire P, Banjara MR, Hanboonkunupakarn B, Imwong M, et al. Epidemiology of plasmodium vivax malaria infection in Nepal. Am J Trop Med Hyg. 2018;99(3):680–7.CrossRef
4.
go back to reference Banjara MR, Kroeger A, Huda MM, Kumar V, Gurung CK, Das ML, et al. Feasibility of a combined camp approach for vector control together with active case detection of visceral leishmaniasis, post kala-azar dermal leishmaniasis, tuberculosis, leprosy and malaria in Bangladesh, India and Nepal: an exploratory study. Trans R Soc Trop Med Hyg. 2015;109(6):408–15.CrossRef Banjara MR, Kroeger A, Huda MM, Kumar V, Gurung CK, Das ML, et al. Feasibility of a combined camp approach for vector control together with active case detection of visceral leishmaniasis, post kala-azar dermal leishmaniasis, tuberculosis, leprosy and malaria in Bangladesh, India and Nepal: an exploratory study. Trans R Soc Trop Med Hyg. 2015;109(6):408–15.CrossRef
5.
go back to reference Pandey BD, Pun SB, Kaneko O, Pandey K, Hirayama K. Case report: expansion of visceral leishmaniasis to the western hilly part of Nepal. Am J Trop Med Hyg. 2011;84(1):107–8.CrossRef Pandey BD, Pun SB, Kaneko O, Pandey K, Hirayama K. Case report: expansion of visceral leishmaniasis to the western hilly part of Nepal. Am J Trop Med Hyg. 2011;84(1):107–8.CrossRef
6.
go back to reference Gautam Ghimire P, Shrestha R, Pandey S, Pokhrel K, Pande R. Cutaneous Leishmaniasis: a neglected tropical vector borne disease in Midwestern region of Nepal. Nepal J Dermatol Venereol Leprol. 2018;16(1):41–4.CrossRef Gautam Ghimire P, Shrestha R, Pandey S, Pokhrel K, Pande R. Cutaneous Leishmaniasis: a neglected tropical vector borne disease in Midwestern region of Nepal. Nepal J Dermatol Venereol Leprol. 2018;16(1):41–4.CrossRef
7.
go back to reference van den Bogaart E, Berkhout MM, Nour AB, Mens PF, Talha AB, Adams ER, et al. Concomitant malaria among visceral leishmaniasis in-patients from Gedarif and Sennar States, Sudan: a retrospective case-control study. BMC Public Health. 2013;13:332.CrossRef van den Bogaart E, Berkhout MM, Nour AB, Mens PF, Talha AB, Adams ER, et al. Concomitant malaria among visceral leishmaniasis in-patients from Gedarif and Sennar States, Sudan: a retrospective case-control study. BMC Public Health. 2013;13:332.CrossRef
8.
go back to reference Singh BJ, Kumar A. Splenic infarctions in mixed infection with kala azar and falciparum malaria. J Assoc Physicians India. 1991;39(3):293.PubMed Singh BJ, Kumar A. Splenic infarctions in mixed infection with kala azar and falciparum malaria. J Assoc Physicians India. 1991;39(3):293.PubMed
9.
go back to reference Albaker W. Acute plasmodium vivax malaria presenting with pancytopenia secondary to hemophagocytic syndrome: case report and literature review. J Fam Community Med. 2009;16(2):71–3. Albaker W. Acute plasmodium vivax malaria presenting with pancytopenia secondary to hemophagocytic syndrome: case report and literature review. J Fam Community Med. 2009;16(2):71–3.
Metadata
Title
A case report of visceral leishmaniasis and malaria co-infection with pancytopenia and splenomegaly - a diagnostic challenge
Authors
Pragya Gautam Ghimire
Prasanna Ghimire
Jyoti Adhikari
Anurag Chapagain
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2019
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-019-4478-1

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