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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Poster presentation

SNP algorithms for prediction of efficacy and adverse events of abatacept (ABT)

Authors: James E Middleton, Tsukasa Matsubara, Keiko Funahashi, Satoru Koyano, Takafumi Hagiwara, Takako Miura, Kosuke Okuda, Takeshi Nakamura, Mitsuyoshi Iwahashi, Tomomi Tsuru, Shoichi Uchimura, Shigeru Honjo

Published in: Arthritis Research & Therapy | Special Issue 1/2012

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Excerpt

Abatacept (ABT), a CTLA4-Ig fusion protein, which inhibits the binding of CD28 and CD80 agents targeted to T-cells, is a relatively new biological agent for RA treatment in Japan. However, there is no method for prediction of responders, non-responders, or adverse events which can occur during treatment. We established SNP algorithms for prediction of responders (R) or non-responders (NR), and adverse events in ABT-treated patients. …
Metadata
Title
SNP algorithms for prediction of efficacy and adverse events of abatacept (ABT)
Authors
James E Middleton
Tsukasa Matsubara
Keiko Funahashi
Satoru Koyano
Takafumi Hagiwara
Takako Miura
Kosuke Okuda
Takeshi Nakamura
Mitsuyoshi Iwahashi
Tomomi Tsuru
Shoichi Uchimura
Shigeru Honjo
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3649

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