Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Poster presentation

The functions of the post-translational modifications in rheumatoid arthritis

Authors: Satoko Aratani, Naoko Yagishita, Teruhisa Kanazawa, Fukami Nakajima, Yoshihisa Yamano, Kusuki Nishioka, Toshihiro Nakajima

Published in: Arthritis Research & Therapy | Special Issue 1/2012

Login to get access

Excerpt

Rheumatoid Arthritis (RA) is a chronic inflammatory joint disease and characterized by synovial hyperplasia. We previously cloned an E3 ubiquitin ligase, Synoviolin, as a regulatory factor of cell proliferation [1]. It suggested that endoplasmic reticulum (ER) associated degradation system (ERAD) via Synoviolin has important roles for overgrowth of synoviocytes [2, 3]. Meanwhile, it is known that autoantibodies to citrullinated proteins are specific for RA and good markers for RA. Peptidyl-Arginine Deiminases 4 (PADI4) is identified as the RA-susceptible gene [3]. However functions of citrulinated proteins are unclear. In this study, we hypothesize that the accumulation of citrullinated proteins in RA synoviocytes could associate for ER stress and explore the crosstalk of ubiquitination and citrullination. …
Literature
1.
Amano T, Yamasaki S, Yagishita N, Tsuchimochi K, Shin H, Kawahara K, Aratani S, Fujita H, Zhang L, Ikeda R, Fujii R, Miura N, Komiya S, Nishioka K, Maruyama I, Fukamizu A, Nakajima T: Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes Dev. 2003, 17 (19): 2436-2449. 10.1101/gad.1096603.PubMedCentralCrossRefPubMed
2.
Yamasaki S, Yagishita N, Sasaki T, Nakazawa M, Kato Y, Yamadera T, Bae E, Toriyama S, Ikeda R, Zhang L, Fujitani K, Yoo E, Tsuchimochi K, Ohta T, Araya N, Fujita H, Aratani S, Eguchi K, Komiya S, Maruyama I, Higashi N, Sato M, Senoo H, Ochi T, Yokoyama S, Amano T, Kim J, Gay S, Fukamizu A, Nishioka K, Tanaka K, Nakajima T: Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. EMBO J. 2007, 26 (1): 113-122. 10.1038/sj.emboj.7601490.PubMedCentralCrossRefPubMed
3.
Yagishita N, Yamasaki S, Nishioka K, Nakajima T: Synoviolin, protein folding and the maintenance of joint homeostasis. Nat Clin Pract Rheumatol. 2008, 4 (2): 91-97. 10.1038/ncprheum0699.CrossRefPubMed
4.
Suzuki A, Yamada R, Chang X, Tokuhiro S, Sawada T, Suzuki M, Nagasaki M, Nakayama-Hamada M, Kawaida R, Ono M, Ohtsuki M, Furukawa H, Yoshino S, Yukioka M, Tohma S, Matsubara T, Wakitani S, Teshima R, Nishioka Y, Sekine A, Iida A, Takahashi A, Tsunoda T, Nakamura Y, Yamamoto K: Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat Genet. 2003, 34 (4): 395-402. 10.1038/ng1206.CrossRefPubMed
Metadata
Title
The functions of the post-translational modifications in rheumatoid arthritis
Authors
Satoko Aratani
Naoko Yagishita
Teruhisa Kanazawa
Fukami Nakajima
Yoshihisa Yamano
Kusuki Nishioka
Toshihiro Nakajima
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3646

Other articles of this Special Issue 1/2012

Arthritis Research & Therapy 1/2012 Go to the issue

Oral presentation

Postnatal Syk deletion in mice clarifies the function of Syk in an anti-collagen antibody-induced arthritis model

Poster presentation

T-regs/Th17 function defect in systemic autoimmunity as a result of "recent thymic emigrants" maturation defect

Poster presentation

Resistance to morphine analgesia and its underlying mechanisms in an experimental mouse model of fibromyalgia

Poster presentation

LC-MS/MS-based shotgun proteomics identified the targets of arthritis-related microRNA

Oral presentation

Skeletal involvement in the pathogenesis and outcomes of rheumatoid arthritis and osteoarthritis

Poster presentation

Osteoprotegerin induction in response to microbial infection
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
Image Credits