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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Poster presentation

Stimulation of bone formation in cortical bone of the mice treated with a novel bone anabolic peptide with osteoclastogenesis inhibitory activity

Authors: Yuriko Furuya, Kohji Uchida, Hisataka Yasuda

Published in: Arthritis Research & Therapy | Special Issue 1/2012

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Excerpt

Receptor activator of nuclear factor-κB ligand (RANKL), a member of tumor necrosis factor (TNF)-α, is produced by osteoblasts (Obs) and stimulates its receptor RANK on osteoclast (Oc) progenitors to differentiate them to osteoclasts. WP9QY peptide designed to mimics TNF receptor's contact site to TNF-α was known to abrogate osteoclastogenesis in vitro by blocking RANKL-RANK signaling. WP9QY ameliorated collagen-induced arthritis and osteoporosis in mouse models. Here we report that the peptide surprisingly exhibited bone anabolic effect in vitro and in vivo. …
Metadata
Title
Stimulation of bone formation in cortical bone of the mice treated with a novel bone anabolic peptide with osteoclastogenesis inhibitory activity
Authors
Yuriko Furuya
Kohji Uchida
Hisataka Yasuda
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3621

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Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
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