Published in:
01-02-2005 | Poster presentation
Abatacept (CTLA4-Ig) modulates human T-cell proliferation and cytokine production but does not affect lipopolysaccharide-induced tumor necrosis factor alpha production by monocytes
Authors:
PM Davis, SG Nadler, KA Rouleau, SJ Suchard
Published in:
Arthritis Research & Therapy
|
Special Issue 1/2005
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Excerpt
Activated T cells play a central role in the inflammatory cascade leading to the joint inflammation and destruction characteristic of rheumatoid arthritis (RA). The cytokines secreted by activated T cells are thought to both initiate and propagate the immunologically driven inflammation associated with RA. …