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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2005

01-02-2005 | Oral presentation

Mechanisms of cartilage matrix turnover: synergistic interactions of proinflammatory cytokines with oncostatin M in upregulating matrix metalloproteinases and ADAMTS metalloproteinases

Authors: TE Cawston, H Bigg, J Milner, J Catterall, T Morgan, E Barksby, W Hui, A Rowan

Published in: Arthritis Research & Therapy | Special Issue 1/2005

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Excerpt

Cartilage is a highly organised tissue where the arrangement of collagen and proteoglycan and minor components is carefully controlled. The chondrocytes maintain a precise balance between anabolic and catabolic processes that maintains this extracellular matrix. Proteoglycan removal is rapid and reversible while collagen removal is slower but, once removed, is difficult to replace. Our main research focus is to discover the mechanism of collagen turnover and we study the members of the matrix metalloproteinase (MMP) family that specifically cleave type II collagen to give characteristic one-quarter and three-quarter fragments; MMP-1, MMP-8, MMP-13 and also MMP-2 and MMP-14 cleave in this way. …
Literature
1.
Cawston TE, Curry VA, Summers CA, et al.: The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint. Arthritis Rheum. 1998, 41: 1760-1771. 10.1002/1529-0131(199810)41:10<1760::AID-ART8>3.0.CO;2-M.CrossRefPubMed
Metadata
Title
Mechanisms of cartilage matrix turnover: synergistic interactions of proinflammatory cytokines with oncostatin M in upregulating matrix metalloproteinases and ADAMTS metalloproteinases
Authors
TE Cawston
H Bigg
J Milner
J Catterall
T Morgan
E Barksby
W Hui
A Rowan
Publication date
01-02-2005
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2005
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1516

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Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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Developed by: Springer Medicine
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