Issue Special Issue 1/2005
25th European Workshop for Rheumatology Research
Content (184 Articles)
Autoimmunity or immune deficiency? On the role and function of regulatory T cells in chronic arthritis
BJ Prakken, I de Kleer
Defining a role for fibroblasts in the persistence of chronic inflammatory joint disease
C Buckley, A Filer, O Haworth, G Parsonage, K Raza, M Salmon
Molecular signatures of rheumatoid arthritis characterized by transcriptome and proteome analysis
MO Glocker, J Kekow, H-J Thiesen
Regulating apoptosis in fibroblasts
T Pap, A Cinski, A Drynda, A Wille, A Baier, S Gay, I Meinecke
Mechanisms of cartilage matrix turnover: synergistic interactions of proinflammatory cytokines with oncostatin M in upregulating matrix metalloproteinases and ADAMTS metalloproteinases
TE Cawston, H Bigg, J Milner, J Catterall, T Morgan, E Barksby, W Hui, A Rowan
Collagenases and aggrecanases: understanding the role of non-catalytic domains in cartilage matrix breakdown
H Nagase, R Visse, M Kashiwagi, C Gendron, Y Itoh
Differential effects of T-cell specific PKC-theta inhibition or selective intra-articular NF-κB inhibition on synovial inflammation in rat adjuvant arthritis
SW Tas, MJ Vervoordeldonk, N Hajji, M May, S Ghosh, PP Tak
Positive cytoplasmic indirect immunofluorescence on HEp2 cells of unknown pattern: what to report to rheumatologists
Z Rotar, B Boziè, B Rozman, T Kveder
Synovial hypoxia inducible factor-1α expression is inversely related to tissue oxygen levels in vivo in inflammatory arthritis
P Donatien, V Sandhu, D Peston, A Sandisson, PC Taylor
Prophylactic administration of abatacept (CTLA4-Ig; BMS-188667) prevents disease induction and bone destruction in a rat model of collagen-induced arthritis
C Kliwinski, D Kukral, J Postelnek, B Krishnan, L Killar, S Nadler, R Townsend
The transcription T-bet is required for optimal proinflammatory trafficking of CD4+T cells
RM Rao, GM Lord, H Choe, AH Lichtman, FW Luscinskas, LH Glimcher
Specificity of CD4 T-cell responses to aggrecan in BALB/c and DR1 transgenic mice
K Lowes, AA von Delwig, N McKie, DM Altmann, JA Goodacre, AD Rowan, JH Robinson
The role of hypoxia in rheumatoid tendon disease
B Sivakumar, N Kang, P Taylor, EM Paleolog
Short-fibre modification facilitates adenovirus-mediated gene delivery in rheumatoid arthritis synoviocytes and synovium: role of RGD and non-RGD binding integrins
M-L Toh, S-S Hong, L Franqueville, L Lindholm, P Boulanger, P Miossec
Laminin type 1 augments the transforming growth factor beta-induced expression of matrix metalloproteinase 3 in synovial fibroblasts
M Hoberg, M Rudert, WK Aicher
Peptide mimetics of anti-dsDNA idiotypes as a tool for lupus-specific IVIG preparation: specificity and efficacy in the treatment of experimental systemic lupus erythematosus
M Blank, I Nur, R Meidler, L Bar, L Slutzki, Y Shoenfeld
Acceleration of apoptotic cells clearance by macrophages upon exposure to serum amyloid P component and its synthetic derivates
L Slutzky, M Blank, G Goddard, M Fridkin, Y Shoenfeld
Close association between valvular heart disease and central nervous system manifestations in antiphospholipid syndrome
I Krause, S Lev, A Fraser, M Blank, J Chapman, Y Shoenfeld
Elevated titers of anti-ribosomal-P antibodies in systemic lupus erythematosus
G Zandman-Goddard, B Gilburd, S Bardechevski, L Stojanovich, P Langevitz, Y Shoenfeld
Human type II collagen is processed in lysosomal compartments of macrophages for presentation of the glycosylated arthritogenic epitope hCII259–273to CD4 T cells in HLA-DR1 transgenic mice
A von Delwig, DM Altmann, JD Isaacs, R Holmdahl, N McKie, JH Robinson
Does the burden of inflammation determined prospectively in patients with early inflammatory arthritis determine the progression of atherosclerosis?
WY Al-Shehhi, S Skehan, E Hefferenan, F Hughes, DJ Veale, B Bresinihan, O Fitzgerald
Altered composition of CD97 splice variants in rheumatoid synovial tissue
FA van Gaalen, TCTM van der Pouw Kraan, RGHH Nelissen, TWJ Huizinga, CL Verweij
Improvement of T-cell function in rheumatoid arthritis (RA) patients in clinical remission is associated with the recovery of IL-7 expression and depends on a familial history of RA
F Ponchel, AK Brown, SL Field, L Hensor, P Emery, JD Isaacs
T-bet expression in rheumatoid arthritis patients with early, disease-modifying anti-rheumatic drug naïve disease is low and correlates with low levels of IL-7 and T-cell dysfunctions
F Ponchel, AK Brown, SL Field, M Quinn, P Conaghan, P Emery, JD Isaacs
The signalling signature downstream of the notch receptor in CD4+CD25highregulatory T cells in RA defines anergic cells: insight into resistance to anti-tumour necrosis factor therapies
MH Buch, K Snow, S Field, P Emery, J Isaacs, F Ponchel
Citrullinated α enolase, a novel citrullinated autoantigen in rheumatoid arthritis, upregulated by chronic inflammation
A Kinloch, V Tatzer, R Wait, D Peston, S Sacre, P Donatien, D Moyes, P Taylor, PJ Venables
Abatacept (CTLA4-Ig) modulates human T-cell proliferation and cytokine production but does not affect lipopolysaccharide-induced tumor necrosis factor alpha production by monocytes
PM Davis, SG Nadler, KA Rouleau, SJ Suchard
Intra-articular gene therapy blocking NF-κB using adeno-associated virus type 5 ameliorates adjuvant arthritis in rats
J Adriaansen, SW Tas, N Hajji, A Bakker, MJ Vervoordeldonk, PP Tak
Collagenous repeat containing sequence of 26 kDa protein: a novel mesenchymal gene of cartilage and adipose tissue differentiation
IH Tarner, C Büchler, J Schölmerich, E Neumann, S Gay, A Schäffler, U Müller-Ladner
Activation of antigen-presenting cells by endogenous retroviral RNA
D Moyes, S Sacre, N Temperton, A Lundberg, B Foxwell, P Venables
Anti-tumour necrosis factor alpha treatment in patients affected by rheumatoid arthritis with anti-Ro/SSA antibodies
I Cavazzana, F Franceschini, E Danieli, P Airò, R Cattaneo
Ha-Ras/ERK1-2 pathway is responsible for oxygen species generation in scleroderma fibroblasts
S Svegliati, MM Luchetti, P Paroncini, A DiCarlo, F Bevilacqua, N Campelli, E Avvedimento, A Gabrielli
Magnetic resonance imaging examinations of the spine in patients with ankylosing spondylitis before and after therapy with the tumor necrosis factor alpha receptor fusion protein etanercept
X Baraliakos, J Davis, W Tsuji, J Braun
Two-year follow-up results after re-administration of etanercept in active ankylosing spondylitis
X Baraliakos, J Brandt, J Listing, H Haibel, HM Rudwaleit, J Sieper, J Braun
Clinical response to the anti-tumor necrosis factor alpha antibody infliximab in patients with ankylosing spondylitis over 3 years
X Baraliakos, J Brandt, J Listing, J Sieper, J Braun
Clinical response to discontinuation of anti-tumor necrosis factor therapy in patients with ankylosing spondylitis after 3 years of continuous treatment with infliximab
X Baraliakos, J Listing, J Brandt, M Rudwaleit, J Sieper, J Braun
Radiographic progression in patients with ankylosing spondylitis after 2 years of treatment with the tumor necrosis factor alpha antibody infliximab
X Baraliakos, J Listing, M Rudwaleit, J Brandt, J Sieper, J Braun
Oxygen radical production determines chondrocyte death and regulates matrix metalloproteinase-mediated matrix degradation during interferon gamma-accelerated immune complex arthritis
PLEM van Lent, KCAM Nabbe, AEM Holthuysen, JK Kolls, SM Holland, WB van den Berg
In systemic sclerosis, levels of tissue kallikrein are related to microvascular changes assayed by videocapillaroscopy and immunohistochemistry
A Del Rosso, AF Milia, LI Manneschi, O Distler, S Guiducci, A Pignone, S Gay, MM Cerinic
A complete phylogenetic analysis coupling expression data from EST databases. An example with a family of genes: the peptidyl arginine deiminase genes
N Balandraud, P Gouret, E Danchin, M Blanc, D Zinn, P Pontarotti
Expression of innate immune receptors in the immunopathologic lesion of primary Sjogren's syndrome: preliminary results
E Bourazopoulou, EK Kapsogeorgou, JG Routsias, DA Liakos, HM Moutsopoulos, AG Tzioufas
The association of different B27 subtypes with the peptide loading complex
JC Goodall, L Ellis, JSH Gaston
Functional regulatory immune responses against human cartilage glycoprotein-39 in health versus proinflammatory responses in rheumatoid arthritis
JHM van Bilsen, H van Dongen, LR Lard, EIH van der Voort, DG Elferink, AM Bakker, AMM Miltenburg, TWJ Huizinga, RRP de Vries, REM Toes
Differential survival of leucocyte subsets by synovial, bone marrow and skin fibroblasts: site-specific rescue of CD4 T cells versus activation-induced rescue of neutrophils
AD Filer, G Parsonage, AMCT Thomas, SJ Curnow, A Akbar, M Salmon, CD Buckley
Regulatory T-cell defect in the arthritis-susceptible DBA/1 mouse
SP Fairchild, M Schenk, R Doffinger, FC Hall
Heme oxygenase 1 regulates osteoclastogenesis
J Zwerina, S Hayer, K Redlich, I Radda, O Hoffmann, JS Smolen, G Schett
How does tumour necrosis factor uncouple T-cell receptor-induced IL-2 gene expression in murine T cells?
JM Clark, K Aleksiyadis, M Panesar, AP Cope
The invasiveness of fibroblast-like synoviocytes is of relevance for the rate of joint destruction in patients with rheumatoid arthritis and is a patient characteristic
TCA Tolboom, AHM van der Helm-van Mil, RGHH Nelissen, FC Breedveld, REM Toes, TWJ Huizinga
A role for IL-7 in regulating CD4+CD25high regulatory T cells
CA Lawson, AK Brown, SL Field, C Burgoyne, P Emery, JD Isaacs, F Ponchel
Results of the Consensus Finding Study Group on Autoantibodies (March 2003–March 2004)
D Hamann, P Charles, M Renz, HP Seelig, A Wiik, RJT Smeenk
Effects of overexpression of PAD4 enzyme in mouse synovium
AJW Zendman, WAM Horstman, AJ Arntz, MB Bennink, ER Vossenaar, WJ van Venrooij, WB van den Berg, FAJ van de Loo, GJM Pruijn
Long-term survival after lymphocytotoxic monoclonal antibody therapy for rheumatoid arthritis
JD Isaacs, AM Clarke, BL Hazleman, G Hale, H Waldmann, DPM Symmons
The persistence of abnormal T-cell differentiation patterns predicts relapse in rheumatoid arthritis patients with controlled disease
A Brown, F Ponchel, J Isaacs, P Emery
The inhibitor of differentiation-2 promotes synovial fibroblast-dependent osteoclastogenesis in rheumatoid arthritis
M Kurowska-Stolarska, J Distler, W Rudnicka, E Neumann, T Pap, R Wenger, A Jungel, BA Michel, U Muller-Ladner, RE Gay, W Maslinski, S Gay, O Distler
Abstract withdrawn
Identification of the EGF-TM7 receptor EMR2 and its ligand dermatan sulphate in rheumatoid synovial tissue
EN Kop, MJ Kwakkenbos, GJD Teske, MC Kraan, TJ Smeets, M Stacey, H-H Lin, J Hamann, PP Tak
Prevalence and specificity of autoantibodies to defensins in sera of patients with systemic autoimmune diseases
AG Terzoglou, JG Routsias, AG Tzioufas, HM Moutsopoulos
Tumor necrosis factor alpha reverses the immunosuppressive properties of mesenchymal stem cells in collagen-induced arthritis
F Djouad, P Plence, C Bony, F Apparailly, C Jorgensen, D Noël
Neutralizing IL-17 during re-activation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and IL-1
MI Koenders, E Lubberts, LAB Joosten, WB van den Berg
Functional Toll-like receptor 9 modulates the activity of bone marrow B cells isolated from rheumatoid arthritis patients
W Rudnicka, E Warnawin, M Buler, T Burakowski, M Bik, E Kontny, C Michalak, P Maldyk, W Maslinski
BiP induces IL-4-dependent regulatory cells
R Brownlie, LK Myers, VM Corrigall, MD Bodman-Smith, SJ Thompson, GS Panayi
High-dose chemotherapy and syngeneic stem cell transplantation in a patient with refractory rheumatoid arthritis: poor response associated with persistence of synovial abnormalities
M van Oosterhout, RJ Verburg, EWN Levarht, D Moolenburgh, I Bajema, RY Barge, WE Fibbe, JM van Laar
Expression of IL-18 in muscle tissue of patients with treatment-resistant idiopathic inflammatory myopathies
IE Lundberg, S Barbasso, AK Ulfgren, JA Gracie, IB McInnes
Evaluation of chondrocyte micromass culture for the study of cartilage degradation
TG Morgan, X Xu, AD Rowan, TE Cawston
A link between complement activation and anti-SSA in immune complex-induced cytokine production in systemic lupus erythematosus
L Mathsson, E Åhlin, H Storfors, J Rönnelid
The value of serum type II collagen epitope measurement in assessing early clinical response to treatment with anti-tumour necrosis factor alpha therapy in rheumatoid arthritis
RH Mullan, T Lobanok, C Walsh, L King, O FitzGerald, B Bresnihan, U Fearon, R Poole, DJ Veale
Oncostatin M in rheumatoid arthritis: a key cytokine acts synergistically with other proinflammatory cytokines to promote human cartilage loss
U Fearon, R Mullan, R Poole, T Markham, O FitzGerald, B Bresnihan, DJ Veale
Methotrexate, through adenosine release, downregulates tumor necrosis factor alpha-induced synovial fibroblast IL-15 expression and proliferation
E Miranda, M Benito, A Balsa, E Martin-Mola
Influence of HLA-DR genes on the production of rheumatoid arthritis-specific autoantibodies to citrullinated fibrin
I Auger, M Sebag, C Vincent, S Guis, L Nogueira, B Svensson, A Cantagrel, G Serre, J Roudier
Bone marrow as a secondary lymphoid organ: mature T-cell subsets in bone marrow from rheumatoid arthritis and osteoarthritis patients
E Warnawin, T Burakowski, L Jung, P Maldyk, W Maslinski
Signaling pathways involved in TRAIL-induced rheumatoid arthritis synovial fibroblast proliferation
J Morel, R Audo, B Combe
Local IL-18 gene transfer prevents severe joint destruction in murine collagen-induced arthritis by induction of IL-4 and osteoprotegerin
LAB Joosten, RL Smeets, MI Koenders, MMA Helsen, B Oppers-Walgreen, FAJ van de Loo, E Lubberts, WB van den Berg
Gene expression profiling provides a link between high inflammatory synovitis and myofibroblast-like synoviocytes
TCG Timmer, PV Kasperkovitz, LGM van Baarsen, P-P Tak, TWJ Huizinga, TCTM van der Pouw Kraan, CL Verweij
Anakinra (Kineret) in psoriasis and psoriatic arthritis: a single-center, open-label, pilot study
A Gibbs, T Markham, C Walsh, B Bresnihan, D Veale, O FitzGerald
Engagement of the p55 TNF-R for different periods of time induces qualitatively distinct pathways of tumour necrosis factor signalling and gene expression profiles in murine T cells
P Vagenas, JM Clark, J Testar, M Panesar, I Udalova, T Freeman, P Lyons, AP Cope
Expression of Toll-like receptor (TLR) 2, TLR3, TLR4 and TLR7 is increased in rheumatoid arthritis synovium and regulates cytokine production by dendritic cells upon stimulation of TLR specific pathways
MF Roelofs, LAB Joosten, S Abdollahi-Roodsaz, AWT van Lieshout, TRDJ Radstake, WB van den Berg
Post-transcriptional regulation of proinflammatory cytokines in arthritis using gene delivery of AU-rich element binding factors
M Khoury, F Apparailly, AR Clark, P Plence, D Noel, C Jorgensen
Arthroscopic lavage with methylprednisolone is superior compared with either treatment alone in patients with inflammatory arthritis of the knee: a randomized prospective trial
M van Oosterhout, JK Sont, I Bajema, FC Breedveld, JM van Laar
Phenotypic, genotypic and functional characterization of mesenchymal stem cells from synovial membrane compared with bone marrow
F Djouad, D Noël, G Uzé, T Haüpl, P Plence, C Bony, F Apparailly, C Jorgensen
Proinflammatory role for AT1receptors in the rat synovium
AG Price, JC Lockhart, JS McLean, WR Ferrell
Proteomic characterisation of cell contact-dependent macrophage activation
MJ Peirce, R Wait, X Wu, S Begum, J Saklatvala, AP Cope
Sustained downregulation of the TCRζ chain defines a transition from antigen mode to inflammation mode during terminal T-cell differentiation
Z Zhang, M Panesar, P Amjadi, A Foey, S Owen, F Dazzi, FM Brennan, AP Cope
Rheumatoid synovial fibroblasts activate endothelial cells and promote neutrophil recruitment in a flow based multicellular model of the rheumatoid pannus
E Smith, F Lally, A Filer, M Stone, J Shaw, GB Nash, CD Buckley, GE Rainger
Impaired early B-cell tolerance in patients with rheumatoid arthritis
J Samuels, Y-S Ng, D Paget, E Meffre
Characterization of the IL-12 family of cytokines in human dendritic cells infected with live Chlamydia trachomatis
MK Matyszak, JC Goodall, JSH Gaston
NKT cell status and IL-10-dependent therapeutic effect of NKT cell stimulation on collagen-arthritis in DBA/1 mice
N Bessis, A Miellot, A Herbelin, R Zhu, M-C Boissier
Distinct patterns of RANKL/osteoprotegerin system modulation through anti-tumour necrosis factor and corticosteroid therapy in rheumatoid arthritis synovium
AI Catrina, D Makrygiannakis, E af Klint, SB Catrina, S Ernestam, L Klareskog, AK Ulfgren
IL-1-driven cartilage and bone destruction are dependent on Toll-like receptor (TLR) 4, but not TLR2
S Abdollahi-Roodsaz, LAB Joosten, MF Roelofs, MMA Helsen, B Oppers-Walgreen, CHM Arndtz, TRDJ Radstake, WB van den Berg
Differential expression of multidrug resistance-related proteins on monocyte-derived macrophages from rheumatoid arthritis patients
R Oerlemans, BAC Dijkmans, JW van der Heijden, WF Lems, A Reurs, GL Scheffer, RJ Scheper, G Jansen
Inhibition of tumour necrosis factor alpha production by activated T cells of rheumatoid arthritis patients by novel anti-folate drugs: an ex vivopilot study
JW van der Heijden, AH Gerards, R Oerlemans, WF Lems, RJ Scheper, LA Aarden, BAC Dijkmans, G Jansen
Marked expression of IL-1 receptors in cell nuclei and muscle fiber membrane in muscle tissue of patients with idiopathic inflammatory myopathies
C Grundtman, S Salomonsson, C Dorph, J Burton, U Andersson, IE Lundberg
Interleukin-1 receptor antagonist lentiviral gene transfer to the murine knee joint ameliorates collagen-induced arthritis
FAJ van de Loo, LM Delavallee, OJ Arntz, MB Bennink, LAB Joosten, WB van den Berg
Effects of anti-rheumatic treatments on the prostaglandin E2 biosynthetic pathway in synovial tissue and synovial fluid cells from patients with rheumatoid arthritis
M Korotkova, M Westman, KR Gheorghe, E af Klint, C Trollmo, A-K Ulfgren, L Klareskog, P-J Jakobsson
Mitogen-activated kinases in psoriatic arthritis: differences in activation and distinct regulation by etanercept therapy
RJU Lories, I Derese, FP Luyten, K de Vlam
Identification of a natural soluble form of the IL-18 receptor accessory protein as an immunomodulator in experimental arthritis
RL Smeets, OJ Arntz, MB Bennink, WB van den Berg, FAJ van de Loo
Gene expression in chronically activated Th cells
U Niesner, I Albrecht, R Baumgrass, M Janitz, H Lehrach, T Haeupl, J Grun, GR Burmester, A Grutzkau, A Radbruch
Intracellular IL-1 receptor antagonist (icIL-1Ra1) does not antagonize growth inhibitory effects of pre-IL-1α in SaOS-2 cells
G Palmer, S Trolliet, D Talabot-Ayer, F Mézin, D Magne, C Gabay
Expression of microsomal prostaglandin E synthase-1 in muscle tissue of patients with idiopathic inflammatory myopathies
M Korotkova, S Barbasso, P-J Jakobsson, I Lundberg
Quantifying the contribution of the second HLA-DRB1 susceptibility allele to the risk of rheumatoid arthritis: a meta-analysis
IA van Rossum, AH Zwinderman, PP Tak, N de Vries
Efficient IL-18 and IL-18BPc adenoviral gene transfer to cultured murine submandibular gland epithelial cells and successful murine retrograde submandibular duct cannulation to modulate IL-18 function in the salivary gland of animal models of Sjogren's syndrome
M Bombardieri, F Barone, G Proctor, FA van de Loo, WB van den Berg, G Valesini, IB McInnes, C Pitzalis
Type 1 regulatory T cells in treatment of murine lupus
R Undeutsch, J Humrich, BH Hahn, F Hiepe, G Burmester, A Radbruch, G Riemekasten
Hearing improvement in a variant Muckle–Wells syndrome case in response to IL-1 receptor antagonism
M Rynne, C Maclean, MF McDermott, P Emery
The cytokine memory of SmD183-119-autoantigen-specific Th cells of systemic lupus erythematosus patients
S Langer, D Langnickel, P Enghard, GR Burmester, F Hiepe, G Riemekasten
PTPN22 as a rheumatoid arthritis susceptibility but not severity gene
J Wesoly, VEH Carlton, A Chokkalingam, AHM van der Helm-van Mil, REM Toes, AB Begovic, TWJ Huizinga
Tryptase as a PAR-2 activator in joint inflammation
EB Kelso, L Dunning, JC Lockhart, WR Ferrell, R Plevin, CP Sommerhoff
HLA DR-DQ haplotypes and genotypes in patients with systemic lupus erythematosus with co-existing Sjogren's syndrome, systemic lupus erythematosus without Sjogren's syndrome and primary Sjogren's syndrome: clinical and laboratory associations
Ch Georgopoulou, E Zintzaras, M Papadimitropoulos, M Spyropoulou, A Stavropoulou, HM Moutsopoulos, MN Manoussakis
Specific inhibition of FoxO transcription factors in rheumatoid arthritis synovial tissue
J Ludikhuize, TJM Smeets, M Vinkenoog, ME Sanders, PP Tak, KA Reedquist
Quantitative and qualitative analysis of CD4+CD25+ regulatory T cells in systemic lupus erythematosus patients
M Bonelli, JS Smolen, C Scheinecker
HSP70/J-protein chaperone machines: expression analysis in granulocytes
A Zgaga-Griesz, A Adolf, S Haak, R Rzepka, I Melchers
Genotype-dependent NOS-3 expression and rheumatoid arthritis
M Cattaruzza, I Melchers, M Hecker
Anti-high-density lipoprotein antibodies and lipoprotein characteristics in systemic lupus erythematosus-related cardiovascular disease
J Su, A Cederholm, E Hurt-Camejo, E Svenungsson, J Frostegård
Discrepancy between jun/fosproto-oncogene mRNA and protein expression in the rheumatoid arthritis synovial membrane
R Huber, B Stuhlmüller, E Kunisch, RW Kinne
Distinct biological properties of human mesenchymal stem cells from different sources
C De Bari, F Dell'Accio, J Vanlauwe, C Pitzalis, FP Luyten
Regulation of T-cell differentiation by IL-4R α-chain single nucleotide polymorphisms
A Skapenko, I Prots, S Mattyasovszky, CL Yoné, JR Kalden, H Schulze-Koops
Role of IL-10 as a susceptibility factor for rheumatoid arthritis and cardiovascular disease
FAS Kurreeman, J De Vries, R Westendorp, AH Van Den Biggelaar, JJM Schonkeren, REM Toes, TWJ Huizinga
Regulation of myeloid cell function and MHC class II expression by tumor necrosis factor
RB Mueller, A Skapenko, M Grunke, J Wendler, B Stuhlmuller, JR Kalden, H Schulze-Koops
Specific contributions of H-Ras and N-Ras GTPases to T-lymphocyte oxidative stress and integrin-dependent retention in rheumatoid arthritis
PHJ Remans, ME Sanders, PP Tak, KA Reedquist
Requirement of IL-17 receptor signaling in resident synoviocytes for development of full blown destructive arthritis
E Lubberts, P Schwarzenberger, W Huang, JR Schurr, JJ Peschon, WB van den Berg, JK Kolls
Different molecules at the surface of stimulated T cells induce IL-1beta, tumour necrosis factor and IL-1RA in human monocytes
D Burger, N Molnarfi, L Gruaz, JM Dayer
Infliximab treatment does not induce apoptosis in peripheral blood mononuclear cells up to 24 hours after initiation of treatment in rheumatoid arthritis patients
CA Wijbrandts, P Reinders-Blankert, P Klarenbeek, TJM Smeets, MJ Vervoordeldonk, PP Tak
Resistance of rheumatoid arthritis synovial fibroblasts to p38 MAP-kinase inhibition of pro-destructive functions mediated by tumor necrosis factor alpha/tumor necrosis factor receptor-1
E Kunisch, B Ukena, R Fuhrmann, A Roth, R Winter, RW Kinne
Patterns of gene expression in rheumatoid arthritis synovial tissue: inter-patient variability greater then intra-patient variability in a small study
J Lindberg, E af Klint, A Stark, T Andersson, P Nilsson, L Klareskog, A Ulfgren, J Lundeberg
Association of FCGR2A and Fc gamma receptor haplotypes with Spanish polymyalgia rheumatica and giant cell arteritis
AW Morgan, MA Gonzalez-Gay, JI Robinson, SJ Babbage, L Haroon-Rashid, AH Hajeer, WER Ollier, JD Isaacs
Noggin haploinsufficiency influences severity of arthritis in different mouse models
M Daans, RJU Lories, I Derese, P Tylzanowski, FP Luyten
Toll-like receptor expression in synovial fibroblasts and normal skin fibroblasts and induction of matrix metallo-proteinase expression by various Toll-like receptor ligands
D Kyburz, F Brentano, O Schorr, BA Michel, RE Gay, S Gay
Exploring mechanisms of inflammatory hyperalgesia in murine collagen-induced arthritis
JJ Inglis, P Anand, P Facer, G Criado, M Feldmann, RO Williams
Association of FCGR3A and FCGR3Bhaplotypes with rheumatoid arthritis and primary Sjögren's syndrome
S Mackie, JI Robinson, JH Barrett, CA Lawson, S Martin, L Haroon-Rashid, D Cooper, SJ Bowman, CT Pease, PG Conaghan, M Green, M Quinn, JD Isaacs, P Emery, AW Morgan
Non-traditional risk and protective factors for cardiovascular disease in systemic lupus erythematosus
A Cederholm, E Svenungsson, D Stengel, G-Z Fei, AG Pockley, E Ninio, J Frostegård
Immunomodulatory effect of unpulsed-immature dendritic cells in collagen-induced arthritis
PL Plence, F Apparailly, LM Van Duivenvoorde, LM Charbonnier, REM Toes, C Jorgensen
Cytokine expression was assessed during antigen-induced arthritis in the synovial membrane, inguinal lymph node, and spleen using competitive RT-PCR and sandwich ELISA
RW Kinne, D Pohlers, A Siegling, E Buchner, CB Schmidt-Weber, E Palombo-Kinne, F Emmrich, R Bräuer
Long-term immune reconstitution after autologous stem-cell transplantation for severe autoimmune diseases
T Alexander, G Massenkeil, E Gromnica-Ihle, GR Burmester, A Radbruch, R Arnold, F Hiepe, A Thiel
The effect of B-cell depletion with an anti-CD20 antibody on the immunoglobulin heavy-chain repertoire in a patient with rheumatoid arthritis
A-S Rouzière, C Kneitz, T Dörner, H-P Tony
Direct analysis of bone turnover in experimental arthritis
K Polzer, B Tuerk, K Redlich, S Hayer, J Smolen, G Schett
Antibodies to ferritin in rheumatoid arthritis are associated with disease severity
D Mewar, DJ Moore, PF Watson, AG Wilson
Polymorphism within the telomeric MHC and expression of rheumatoid arthritis candidate genes
D Mewar, I Marinou, JM Timms, R Kilding, AG Wilson
Synovial monocytes mediate Rap1-dependent oxidative stress in rheumatoid arthritis T lymphocytes
PH Remans, JM van Laar, ME Sanders, P-P Tak, KA Reedquist
Binding properties of anti-histone H1 antibodies suggest that nuclei of necrotic cells rather than cells undergoing apoptosis are engulfed in the LE cell phenomenon
E Feierl, JS Smolen, T Karonitsch, GH Stummvoll, H Ekhart, CW Steiner, M Aringer
Stat1 and phosphorylated Stat1 are increased in lymphocytes and monocytes of patients with systemic lupus erythematosus
M Aringer, T Karonitsch, CW Steiner, E Feierl, G Steiner, JS Smolen
Kinetic and influence of angiogenesis in the course of collagen-induced arthritis
G Clavel, C Valvason, D Lemeiter, M-C Boissier, N Bessis
Free radicals regulate glucocorticoid-induced apoptosis in T lymphocytes
PHJ Remans, DM Gerlag, MS Sanders, P Reinders-Blankert, KA Reedquist, PP Tak
T-cell receptor-independent induction of interferon gamma expression in human memory Th cells
A Sattler
Active immunization (vaccination) against peptides of IL-1β induces self anti-IL-1β antibodies and protects against collagen-induced arthritis
N Bessis, S Bertin-Maghit, C Capini, J Chomilier, S Muller, J-F Zagury, M-C Boissier
Autoreactive T cells to histone H1 and core histones in patients with systemic lupus erythematosus
GH Stummvoll, R Fritsch, B Meyer, M Aringer, JS Smolen, G Steiner
CCL21 relationship with lymphoid neogenesis and lymphatic vascular system in chronically inflamed synovium
A Manzo, S Bugatti, C Buckley, D Jackson, R Caporali, C Montecucco, C Pitzalis
Microparticles from inflammatory cells are strong inducers of matrix metalloproteinases and inflammatory cytokines in synovial fibroblasts
JHW Distler, A Jüngel, LC Huber, A Seemayer, RE Gay, BA Michel, JR Kalden, S Gay, DS Pisetsky, O Distler
FcγR-mediated uptake and processing of antigen–immunoglobulin complexes by professional antigen-presenting cells
JMH de Jong, DH Schuurhuis, A Ioan-Facsinay, EIH van der Voort, TJW Huizinga, F Ossendorp, JS Verbeek, REM Toes
Treatment of collagen-induced arthritis with cholera toxin-treated dendritic cells
G Criado, JJ Inglis, M Feldmann, RO Williams
Decreased binding of annexin V to endothelial cells: a novel mechanism of atherothrombosis in patients with systemic lupus erythematosus
A Cederholm, E Svenungsson, K Jensen-Urstad, C Trollmo, A-K Ulfgren, J Swedenborg, G-Z Fei, J Frostegård
TLR-9, but not TLR-2, TLR-3 and TLR-4, is upregulated on peripheral blood mononuclear cells of patients with active systemic lupus erythematosus
ED Papadimitraki, E Koutala, G Bertsias, C Choulaki, H Kritikos, P Sidiropoulos, DT Boumpas
Bystander-activated CD4+memory lymphocytes: a role in the pathology of rheumatoid arthritis?
JT Beech, SH Owen, P Green, P Amjadi, FM Brennan
In vivo induction of foxp3 in collagen-induced arthritis treatment with modified dendritic cells
G Falgarone, O Jaen, MC Boissier
Investigation of the relationship between the HLADRB1 genotype and the presence of autoantibody to cyclic-citrullinated peptide in patients with rheumatoid arthritis
M Brózik, Z Weiszhár, JRP Gergely, K Merétey, G Poór
Endothelial function and activation in women with systemic lupus erythematosus
E Svenungsson, A Cederholm, K Jensen-Urstad, G-Z Fei, J Frostegard
Citrullinated peptide-specific CD19+B cells are present in synovial tissue and peripheral blood of patients with rheumatoid arthritis
S Ruzickova, Z Cimburek, T Moravcova, Z Huzlova, I Vesela, J Niederlova, O Krystufkova, J Vencovsky
Identification of genes associated with the presence of ectopic lymphoid structures in rheumatoid arthritis synovial tissues
B Baltus, RE Mebius, M Vondenhoff, TWJ Huizinga, PP Tak, CL Verweij, TCTM van der Pouw Kraan
Immunophenotype and functional characteristics of rheumatoid arthritis derived myeloid dendritic cells and plasmacytoid dendritic cells
S Jongbloed, JA Gracie, RD Sturrock, IB McInnes
The importance of cell surface RANKL in rheumatoid arthritis
O Krystufkova, J Sinkora, K Jarosova, M Hladikova, J Niederlova, Z Rehakova, D Tegzova, S Ruzickova, J Vencovsky
Expression of programmed death (PD)-1 and PD-1 ligands (PD-L1, PD-L2) in peripheral blood mononuclear cells of patients with systemic lupus erythematosus
G Bertsias, A Raptopoulou, E Coutala, M Mamoulaki, H Kritikos, P Sidiropoulos, DT Boumpas
Cultured salivary gland epithelial cells from patients with primary Sjögren's syndrome and disease controls are sensitive to signaling via Toll-like receptors 2 and 3: upregulation of intercellular adhesion molecule-1 expression
MP Spachidou, EK Kapsogeorgou, EA Bourazopoulou, HM Moutsopoulos, MN Manoussakis
Prevalence of non-rheumatoid arthritis-associated autoantibodies in sera of anti-cyclic citrulline antibody-positive patients
M Brozik, U Böhm, J Csiki, A Polgár, ZS Schmidt, ZS Balogh, M Seszták, J Ortutay, G Bálint, G Hittner, P Bálint, J Korda, L Hodinka, K Meretey
Identification of hnRNP-A2 (RA33) as a major B-cell and T-cell autoantigen in pristane–induced arthritis
MH Hoffmann, J Tuncel, K Skriner, M Tohidast-Akrad, G Schett, JS Smolen, R Holmdahl, G Steiner
Influence of methotrexate, leflunomide and tumour necrosis factor alpha inhibitors on immune competence in rheumatoid arthritis patients: a long-run monitoring of Epstein–Barr virus load
N Balandraud, S Guis, JB Meynard, I Auger, H Sovran, J Roudier, C Roudier
A revised assay for the measurement of T-cell receptor excision circles as a quantitative measure of thymic function in systemic lupus erythematosus
AR Lorenzi, AM Patterson, JD Isaacs
Microarray analysis for molecular characterization of disease activity and measuring outcomes of anti-tumour necrosis factor therapy in rheumatoid arthritis
B Stuhlmüller, T Häupl, N Tandon, M Hernandez, C Hultschig, RJ Kuban, J Salfeld, GR Burmester
Amelioration of joint inflammation by a PAR-2-specific monoclonal antibody
V King, EB Kelso, JC Lockhart, L Dunning, WR Ferrell, JA Gracie, IB McInnes
Real-time quantitative PCR used as a biomarker for synovial gene expression after oral prednisolone therapy in patients with rheumatoid arthritis
DM Gerlag, DL Boyle, P Laud, T Nash, PP Tak, GS Firestein
Expression profiling in synovitis: ranking of candidates, diagnostic performance and individualized interpretation
T Häupl, A Grützkau, J Grün, V Krenn, M Rudwaleit, B Stuhlmüller, C Kaps, J Zacher, G Burmester, A Radbruch
A role for CD8 cells in cell-contact-mediated inflammation
SE Robertson, A Crilly, JA Gracie, P Life, IB McInnes
Complement and Fc receptor cross-talk in the Arthus reaction: the inflammatory cascade confirmed and refined
SR Ali, J Skokowa, N Shushakova, S Konrad, RE Schmidt, JE Gessner
Pharmacokinetic study of oral prednisolone compared with intravenous methylprednisolone in patients with vasculitis of rheumatic disease
KA Rouster-Stevens, JA Daru, LM Pachman, B Javonovic, K-L Ngai
Toll-like receptor 4 polymorphisms and ankylosing spondylitis
R Adam, JA Gracie, RD Sturrock
Follow up study of B-lymphocyte depletion in the treatment of patients with systemic lupus erythematosus
MJ Leandro, JCW Edwards, MR Ehrenstein, G Cambridge, DA Isenberg