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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2005

01-02-2005 | Poster presentation

Efficient IL-18 and IL-18BPc adenoviral gene transfer to cultured murine submandibular gland epithelial cells and successful murine retrograde submandibular duct cannulation to modulate IL-18 function in the salivary gland of animal models of Sjogren's syndrome

Authors: M Bombardieri, F Barone, G Proctor, FA van de Loo, WB van den Berg, G Valesini, IB McInnes, C Pitzalis

Published in: Arthritis Research & Therapy | Special Issue 1/2005

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Excerpt

We recently demonstrated that the proinflammatory and immuno-regulatory cytokine IL-18 is strongly upregulated in salivary glands (SG) of Sjogren's syndrome (SS) patients. IL-18 gain or loss of function experiments in animal models of human diseases have provided evidence of the pathogenic role of this cytokine in chronic inflammation. However, in SS the pathogenic relevance of IL-18 in the development of murine autoimmune sialoadenitis has not as yet been evaluated. Here we describe in vitro experiments in which murine SG epithelial cells were tested for transfection efficiency with IL-18 and IL-18BPcAdV gene transfer. In addition, in preparation for in vivo SG modulation of IL-18 function by AdV-mediated gene transfer, we optimised retrograde SG cannulation in mice. …
Literature
1.
Walter DM, Wong CP, DeKruyff RH, Berry GJ, Levy S, Umetsu DT: Il-18 gene transfer by adenovirus prevents the development of and reverses established allergen-induced airway hyperreactivity. J Immunol. 2001, 166: 6392-6398.CrossRefPubMed
2.
Smeets RL, van de Loo FA, Arntz OJ, Bennink MB, Joosten LA, Van Den Berg WB: Adenoviral delivery of IL-18 binding protein C ameliorates collagen-induced arthritis in mice. Gene Ther. 2003, 10: 1004-1011. 10.1038/sj.gt.3301986.CrossRefPubMed
Metadata
Title
Efficient IL-18 and IL-18BPc adenoviral gene transfer to cultured murine submandibular gland epithelial cells and successful murine retrograde submandibular duct cannulation to modulate IL-18 function in the salivary gland of animal models of Sjogren's syndrome
Authors
M Bombardieri
F Barone
G Proctor
FA van de Loo
WB van den Berg
G Valesini
IB McInnes
C Pitzalis
Publication date
01-02-2005
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2005
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1615

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