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Published in: Arthritis Research & Therapy 3/2004

01-09-2004 | Poster presentation

Activation of peroxisome proliferator-activated receptor γ inhibits IL-1β-induced mPGES-1 expression in human synovial fibroblasts by interfering with Egr-1

Authors: S Cheng, H Afif, J Martel-Pelletier, J-P Pelletier, X Li, K Farrajota, M Lavigne, H Fahmi

Published in: Arthritis Research & Therapy | Special Issue 3/2004

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Excerpt

Membrane-associated prostaglandin (PG) E synthase-1 (mPGES-1) catalyzes the conversion of PGH2 to PGE2, which plays a critical role in the pathogenesis of arthritis. Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor and was shown to regulate a number of inflammatory genes in several cell types. In this study, we examined the effect of PPARγ ligands on IL-1β-induced mPGES-1 expression in human synovial fibroblasts. …
Metadata
Title
Activation of peroxisome proliferator-activated receptor γ inhibits IL-1β-induced mPGES-1 expression in human synovial fibroblasts by interfering with Egr-1
Authors
S Cheng
H Afif
J Martel-Pelletier
J-P Pelletier
X Li
K Farrajota
M Lavigne
H Fahmi
Publication date
01-09-2004
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 3/2004
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1401

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