Published in:
01-09-2004 | Poster presentation
Activation of peroxisome proliferator-activated receptor γ inhibits IL-1β-induced mPGES-1 expression in human synovial fibroblasts by interfering with Egr-1
Authors:
S Cheng, H Afif, J Martel-Pelletier, J-P Pelletier, X Li, K Farrajota, M Lavigne, H Fahmi
Published in:
Arthritis Research & Therapy
|
Special Issue 3/2004
Login to get access
Excerpt
Membrane-associated prostaglandin (PG) E synthase-1 (mPGES-1) catalyzes the conversion of PGH2 to PGE2, which plays a critical role in the pathogenesis of arthritis. Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor and was shown to regulate a number of inflammatory genes in several cell types. In this study, we examined the effect of PPARγ ligands on IL-1β-induced mPGES-1 expression in human synovial fibroblasts. …