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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 3/2004

01-09-2004 | Poster presentation

Effects of hypoxia on protein and gene expression in fibroblast-like synoviocytes

Authors: H El-Gabalawy, K Dasuri, C Hitchon, K Wong, G Ma, M Koshiji, S Der, O Wilkins, E Huang, J Wilkins

Published in: Arthritis Research & Therapy | Special Issue 3/2004

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Excerpt

The synovial microenvironment in rheumatoid arthritis (RA) is often hypoxic with evidence of anaerobic metabolism. This results from an imbalance between high metabolic demands and impaired tissue perfusion due to microvascular damage. Cellular responses to hypoxia are mediated by the transcription factor HIF-1α, which is exquisitely and rapidly controlled by cellular oxygen tension. HIF-1α has been shown to play a key role in promoting tumor angiogenesis, and was recently shown to be critically important in inflammatory responses. …
Metadata
Title
Effects of hypoxia on protein and gene expression in fibroblast-like synoviocytes
Authors
H El-Gabalawy
K Dasuri
C Hitchon
K Wong
G Ma
M Koshiji
S Der
O Wilkins
E Huang
J Wilkins
Publication date
01-09-2004
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 3/2004
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1432

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Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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Developed by: Springer Medicine
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