Published in:
01-09-2004 | Poster presentation
Lymphoid chemokine expression in Sjogren's syndrome: relationship with the lymphoid organization of the periductal inflammatory aggregates
Authors:
F Barone, M Bombardieri, MC Blades, A Manzo, P Morgan, S Challacombe, G Valesini, C Pitzalis
Published in:
Arthritis Research & Therapy
|
Special Issue 3/2004
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Excerpt
The inflammatory cellular infiltrate typical of several chronic diseases, including Sjogren syndrome (SS), is often organized in lymphoid-like structures. CXCL13 and CCL21 are lymphoid chemokines critical for physiologic development of secondary lymphoid organs. They have also been implicated in the formation of ectopic lymphoid neogenesis in various experimental and pathological conditions. To define the relationship between the in situ production of CXCL13 and CCL21 and lymphoid organization in SS we examined the expression of these chemokines in relation to the degree of B-cell and T-cell segregation, the presence of follicular dendritic cell (FDC) (CD21+) networks and germinal centre (GC) reactions as well as the development of high endothelial venule (HEV) (PNAd+)-like vessels. …
