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Experimental Hematology & Oncology
Published in: Experimental Hematology & Oncology 1/2021

Open Access 01-12-2021 | NSCLC | Review

Predictive biomarkers of anti-PD-1/PD-L1 therapy in NSCLC

Authors: Mengke Niu, Ming Yi, Ning Li, Suxia Luo, Kongming Wu

Published in: Experimental Hematology & Oncology | Issue 1/2021

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Abstract

Immunotherapy, especially anti-programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) treatment has significantly improved the survival of non-small cell lung cancer (NSCLC) patients. However, the overall response rate remains unsatisfactory. Many factors affect the outcome of anti-PD-1/PD-L1 treatment, such as PD-L1 expression level, tumor-infiltrating lymphocytes (TILs), tumor mutation burden (TMB), neoantigens, and driver gene mutations. Further exploration of biomarkers would be favorable for the best selection of patients and precisely predict the efficacy of anti-PD-1/PD-L1 treatment. In this review, we summarized the latest advances in this field, and discussed the potential applications of these laboratory findings in the clinic.
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Metadata
Title
Predictive biomarkers of anti-PD-1/PD-L1 therapy in NSCLC
Authors
Mengke Niu
Ming Yi
Ning Li
Suxia Luo
Kongming Wu
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Experimental Hematology & Oncology / Issue 1/2021
Electronic ISSN: 2162-3619
DOI
https://doi.org/10.1186/s40164-021-00211-8

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