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BMC Neurology

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Open Access 01-12-2021 | Magnetic Resonance Imaging | Case report

MOG antibody-associated encephalitis secondary to Covid-19: case report

Authors: Ervin Durovic, Corinna Bien, Christian G. Bien, Stefan Isenmann

Published in: BMC Neurology | Issue 1/2021

Abstract

Background

While Covid-19 predominantly affects the respiratory system, neurological manifestations including encephalitis occur in some patients, possibly affecting the course and outcome of the disease. Here, we describe a unique case of a young man with Covid-19 and transient MOG-positive encephalitis, with a benign course.

Case presentation

A 22-year-old male, with PCR confirmed Covid-19 infection was admitted because of persistent headache. The clinical examination was normal. Neuropsychological testing revealed distinct executive deficits. Brain MRI and cerebrospinal fluid (CSF) analysis were suggestive for encephalitis. Further laboratory examination revealed a serum MOG antibody titre. The headache improved with analgetic treatment and i.v. methylprednisolone. Consequently, the MOG antibody titer decreased and MRI lesions were resolving. The patient made a full recovery, with no signs of deterioration over the following months.

Conclusions

Covid-19 manifestations in the CNS include encephalitis with variable course and prognosis. This case highlights a possible association between inflammation due to COVID-19 and transient secondary autoimmunity with transient MOG antibodies and atypical clinical presentation.

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Title: MOG antibody-associated encephalitis secondary to Covid-19: case report
Authors: Ervin Durovic
Corinna Bien
Christian G. Bien
Stefan Isenmann
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Cranial MRI
SARS-CoV-2
COVID-19
Polymerase Chain Reaction
Headache
Encephalitis
Published in: BMC Neurology / Issue 1/2021
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-021-02449-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

MOG antibody-associated encephalitis secondary to Covid-19: case report

Abstract

Background

Case presentation

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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