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01-08-2020 | Cranial MRI | Letter to the Editor

Sunitinib associated posterior reversible encephalopathy syndrome in a patient treated for GIST

Authors: Nicola Rifino, Vittorio Mantero, Marco Giuseppe Filizzolo, Paola Basilico, Chiara Scaccabarozzi, Jessica Arnoffi, Andrea Salmaggi

Published in: Acta Neurologica Belgica | Issue 4/2020

Excerpt

Posterior reversible encephalopathy syndrome (PRES) is an acute neurological disorder characterized by headache, visual disturbances, seizures and vigilance status alteration. It is characterized by white matter vasogenic oedema affecting the posterior occipital and parietal lobes of the brain predominantly and it is often associated with acute hypertension. If promptly recognized and treated, the prognosis is usually favorable and the changes seen in magnetic resonance imaging (MRI) resolve over days to weeks [1]. …

Fugate JE, Rabinstein AA (2015) Posterior reversible encephalopathy syndrome: clinical and radiological manifestations, pathophysiology, and outstanding questions. Lancet Neurol 14(9):914–925. https://doi.org/10.1016/S1474-4422(15)00111-8 CrossRefPubMed

Fisher M, Schmutzhard E (2017) Posterior reversible encephalopathy syndrome. J Neurol 264(8):1608–1616CrossRef

Christophe LT, Eric R, Sandrine F (2007) Sunitinib: a novel tyrosine kinase inhibitor. A brief review of its therapeutic potential in the treatment of renal carcinoma and gastrointestinal stromal tumors (GIST). Ther Clin Risk Manag 3(2):341–348. https://doi.org/10.2147/tcrm.2007.3.2.341 CrossRef

Saraceno L, Ricigliano AGV, Cavalli M, Meola G (2017) Posterior reversible encephalopathy syndrome after long-term treatment with low-dose sunitinib: a case report. Neurol Sci 38:1119–1121. https://doi.org/10.1007/s10072-017-2851-7 CrossRefPubMed

Jonathan WS, Bérenger L, Frédérique B-S, Stephan E, Christophe M, Jérôme M (2020) Pazopanib-induced posterior reversible encephalopathy syndrome with possible syndrome of inappropriate secretion of antidiuretic hormone: an incidental or pathophysiological association? Neural Regen Res 15(6):1166–1168. https://doi.org/10.4103/1673-5374.270420 CrossRef

Title: Sunitinib associated posterior reversible encephalopathy syndrome in a patient treated for GIST
Authors: Nicola Rifino
Vittorio Mantero
Marco Giuseppe Filizzolo
Paola Basilico
Chiara Scaccabarozzi
Jessica Arnoffi
Andrea Salmaggi
Publication date: 01-08-2020
Publisher: Springer International Publishing
Keywords: Cranial MRI
Gastrointestinal Stromal Tumor
Hypertension
Imatinib
Sunitinib
Posterior Reversible Encephalopathy Syndrome
Hypertension
Published in: Acta Neurologica Belgica / Issue 4/2020
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-020-01367-6

Keynote webinar | Spotlight on sleep in brain health

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Sunitinib associated posterior reversible encephalopathy syndrome in a patient treated for GIST

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Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

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