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01-12-2020 | Fifth Disease | Case Report

Acute viral encephalitis associated with human parvovirus B19 infection: unexpectedly diagnosed by metagenomic next-generation sequencing

Authors: Jing Cao, Xiao-Qun Zhu

Published in: Journal of NeuroVirology | Issue 6/2020

Abstract

We report here a case of a 17-year-old boy with viral encephalitis associated with human parvovirus B19 who presented consciousness disturbance, left hemiparesis, and focal neurologic signs. The diagnosis was based on the specific sequence reads corresponding to human parvovirus B19 (PVB19) in a CSF sample as analyzed by metagenomic next-generation sequencing (mNGS). Thus, PVB19 should be considered in the differential diagnosis of encephalitis and encephalopathy of unknown etiology. The introduction of mNGS into the diagnostic protocol of neuropathies, especially for those undiagnosed, could interrogate all genetic information in a biologic sample and facilitate the identification of the etiological agent.

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Title: Acute viral encephalitis associated with human parvovirus B19 infection: unexpectedly diagnosed by metagenomic next-generation sequencing
Authors: Jing Cao
Xiao-Qun Zhu
Publication date: 01-12-2020
Publisher: Springer International Publishing
Keywords: Fifth Disease
Encephalitis
Encephalopathy
Published in: Journal of NeuroVirology / Issue 6/2020
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-020-00885-6

At a glance: The STEP trials

Springer Medicine

Acute viral encephalitis associated with human parvovirus B19 infection: unexpectedly diagnosed by metagenomic next-generation sequencing

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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