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Open Access 01-12-2020 | Human Immunodeficiency Virus

The University of California San Diego performance-based skills assessment: a useful tool to detect mild everyday functioning difficulties in HIV-infected patients with very good immunological condition

Authors: Valentina Delle Donne, Nicoletta Ciccarelli, Valentina Massaroni, Alberto Borghetti, Alex Dusina, Damiano Farinacci, Elena Visconti, Enrica Tamburrini, Massimiliano Fabbiani, Simona Di Giambenedetto

Published in: Journal of NeuroVirology | Issue 6/2020

Abstract

Everyday functioning (EF) impairment is frequent in people living with HIV (PLWH). Our aim was to better explore EF and its association with PLWH cognition, by administering both the IADL scale, the most common functional scale, and a new and ecologic multi-domain (communication and financial skills) tool to measure EF as the University of California San Diego (UCSD) Performance-Based Skills Assessment-Brief Version (UPSA-B). Eighty-five PLWH on cART with very good immunological condition and 23 age- and education-matched healthy controls (HC) were enrolled. PLWH underwent a standardized neuropsychological battery plus IADL, and cognitive impairment was defined according to Frascati criteria. Both groups underwent the UPSA-B. Only 6 subjects (7%) were affected by cognitive impairment (asymptomatic profile). While IADL score was at ceiling for all patients, the UPSA-B total score was significantly worse in PLWH when compared with HC [mean 82.1 (SD 9.3) vs 89.2 (SD 6.2); p < 0.001]. At communication subtest, PLWH group and HC were significantly different (p = 0.002), while no difference emerged at financial skills (p = 0.096). Higher score at UPSA-B was independently associated with better global cognitive performance (composite Z-score) (β 7.79; p < 0.001). Also considering each single cognitive domain, UPSA-B performance (both total and at subtests) confirmed the association with neurocognitive performance. In conclusion, UPSA-B seems to better discriminate EF impairment than IADL in PLWH, and it was associated with cognitive functions, also in the absence of symptomatic cognitive impairment. Thus, it appears a promising tool in the context of HIV infection to avoid misdiagnosis and to better detect also mild EF.

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Title: The University of California San Diego performance-based skills assessment: a useful tool to detect mild everyday functioning difficulties in HIV-infected patients with very good immunological condition
Authors: Valentina Delle Donne
Nicoletta Ciccarelli
Valentina Massaroni
Alberto Borghetti
Alex Dusina
Damiano Farinacci
Elena Visconti
Enrica Tamburrini
Massimiliano Fabbiani
Simona Di Giambenedetto
Publication date: 01-12-2020
Publisher: Springer International Publishing
Keyword: Human Immunodeficiency Virus
Published in: Journal of NeuroVirology / Issue 6/2020
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-020-00891-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The University of California San Diego performance-based skills assessment: a useful tool to detect mild everyday functioning difficulties in HIV-infected patients with very good immunological condition

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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