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Open Access 01-12-2016 | Review Article

Deciphering the role of DNA methylation in multiple sclerosis: emerging issues

Authors: Maria Sokratous, Efthimios Dardiotis, Zisis Tsouris, Eleni Bellou, Amalia Michalopoulou, Vasileios Siokas, Stylianos Arseniou, Tzeni Stamati, Georgios Tsivgoulis, Dimitrios Bogdanos, Georgios M. Hadjigeorgiou

Published in: Autoimmunity Highlights | Issue 1/2016

Abstract

Multiple sclerosis (MS) is an autoimmune inflammatory and neurodegenerative disease of the central nervous system that involves several not yet fully elucidated pathophysiologic mechanisms. There is increasing evidence that epigenetic modifications at level of DNA bases, histones, and micro-RNAs may confer risk for MS. DNA methylation seems to have a prominent role in the epigenetics of MS, as aberrant methylation in the promoter regions across genome may underlie several processes involved in the initiation and development of MS. In the present review, we discuss current understanding regarding the role of DNA methylation in MS, possible therapeutic implications and future emerging issues.

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Title: Deciphering the role of DNA methylation in multiple sclerosis: emerging issues
Authors: Maria Sokratous
Efthimios Dardiotis
Zisis Tsouris
Eleni Bellou
Amalia Michalopoulou
Vasileios Siokas
Stylianos Arseniou
Tzeni Stamati
Georgios Tsivgoulis
Dimitrios Bogdanos
Georgios M. Hadjigeorgiou
Publication date: 01-12-2016
Publisher: Springer International Publishing
Published in: Autoimmunity Highlights / Issue 1/2016
Print ISSN: 2038-0305
Electronic ISSN: 2038-3274
DOI: https://doi.org/10.1007/s13317-016-0084-z

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