Top

Published in:

01-11-2011 | Review Article

MicroRNAs in autoimmune disease

Authors: Vivek K. Rauniyar, Wei Wu, Huan Yang

Published in: Autoimmunity Highlights | Issue 2/2011

Abstract

MicroRNAs (miRNAs) are non-coding, single-stranded small RNAs, usually 18–25 nucleotides long, have ability to regulate gene expression post-transcriptionally. miRNAs are highly homologous, conserved and are found in various living organisms including plants and animals. Present studies show that these small RNAs anticipate and are directly involved in many important physiological and pathological processes including growth, proliferation, maturation, metabolism, and inflammation among others. Evidences are accumulating that miRNAs play active role in directing immune responses and, therefore, might be involved in pathogenesis of autoimmune diseases. Recent studies have found that miRNAs are critical in proliferation, maturation and differentiation of T cells, B cells and, therefore, may affect the outcome of an immune response. In light of such understanding, this review briefly introduces miRNAs and discusses its role in the pathogenesis of various autoimmune diseases, as well as its potential as a biomarker and therapeutic target in the management of autoimmune diseases.

He L, Hannon GJ (2004) MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 5(7):522–531PubMedCrossRef

Filipowicz W, Bhattacharyya SN, Sonenberg N (2008) Mechanisms of posttranscriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 9(2):102–114PubMedCrossRef

Lee RC, Feinbaum RL, Ambros V (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75:843–854PubMedCrossRef

http://mirbase.org. Accessed March 2011

Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116(2):281–297PubMedCrossRef

Neilson JR, Zheng GX, Burge CB et al (2007) Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes Dev 21:578–589PubMedPubMedCentralCrossRef

Monticelli S et al (2005) MicroRNA profiling of the murine hematopoietic system [J]. Genome Biol 6(8):R71PubMedPubMedCentralCrossRef

Lee Y et al (2004) MicroRNA genes are transcribed by RNA polymerase II. EMBO J 23:4051–4060PubMedPubMedCentralCrossRef

Yi R, Qin Y, Macara IG, Cullen BR (2003) Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev 17:3011–3016PubMedPubMedCentralCrossRef

10.

Chendrimada TP et al (2007) MicroRNA silencing through RISC recruitment of eIF6. Nature 447:823–828PubMedCrossRef

11.

Hunt EA, Goulding AM, Deo SK (2009) Direct detection and quantification of microRNAs. Anal Biochem 387(1):1–12PubMedCrossRef

12.

de Planell-Saguer M, Rodicio MC, Mourelatos Z (2010) Rapid in situ codetection of noncoding RNAs and proteins in cells and formalin-fixed paraffin-embedded tissue sections without protease treatment. Nat Protoc 5(6):1061–1073PubMedCrossRef

13.

Baltimore D, Boldin MP, O’Connell RM, Rao DS, Taganov KD (2008) MicroRNAs; new regulators of immune cell development and function. Nat Immunol 9(8):839–845PubMedCrossRef

14.

Zhou B, Wang S, Mayr C et al (2007) miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc Natl Acad Sci USA 104:7080–7085PubMedPubMedCentralCrossRef

15.

Fazi F et al (2005) A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPα regulates human granulopoiesis. Cell 123:819–831PubMedCrossRef

16.

Taganov KD, Boldin MP, Chang KJ, Baltimore D (2006) NF-kappa B-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA 103(33):12481–12486PubMedPubMedCentralCrossRef

17.

O’Connell RM, Taganov KD, Boldin MP, Cheng G, Baltimore D (2007) MicroRNA-155 is induced during the macrophage inflammatory response. Proc Natl Acad Sci USA 104(5):1604–1609PubMedPubMedCentralCrossRef

18.

Tili E et al (2007) Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol 179(8):5082–5089PubMedCrossRef

19.

Johnnidis JB et al (2008) Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature 451:1125–1129PubMedCrossRef

20.

Muljo SA et al (2005) Aberrant T cell differentiation in the absence of Dicer. J Exp Med 202:261–269PubMedPubMedCentralCrossRef

21.

Koralov SB et al (2008) Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell 132:860–874PubMedCrossRef

22.

Cuesta R, Martínez-Sánchez A, Gebauer F (2009) miR-181a regulates cap-dependent translation of p27 (kip1) mRNA in myeloid cells. Mol Cell Biol 29(10):2841–2851PubMedPubMedCentralCrossRef

23.

Chen CZ, Li L, Lodish HF et al (2004) MicroRNAs modulate hematopoietic lineage differentiation. Science 303:83–86PubMedCrossRef

24.

Liu G, Min H, Yue S et al (2008) Pre-miRNA loop nucleotides control the distinct activities of mir-181a-1 and mir-181c in early T cell development. PLOS ONE 3:e3592PubMedPubMedCentralCrossRef

25.

Li Q et al (2007) miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell 129:147–161PubMedCrossRef

26.

Eis PS, Tam W, Sun L et al (2005) Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc Natl Acad Sci USA 102:3627–3632PubMedPubMedCentralCrossRef

27.

Calin GA, Croce CM (2006) MicroRNA signatures in human cancers. Nat Rev Cancer 6(11):857–866PubMedCrossRef

28.

Costinean S et al (2006) Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc Natl Acad Sci USA 103(18):7024–7029PubMedPubMedCentralCrossRef

29.

Fulci V, Chiaretti S, Goldoni M et al (2007) Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia. Blood 109:4944–4951PubMedCrossRef

30.

Rodriguez A, Vigorito E, Clare S et al (2007) Requirement of bic/microRNA-155 for normal immune function. Science 316:608–611PubMedPubMedCentralCrossRef

31.

Thai TH, Calado DP, Casola S et al (2007) Regulation of the germinal center response by microRNA-155. Science 316:604–608PubMedCrossRef

32.

Kohlhaas S, Garden OA, Scudamore C et al (2009) Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells. J Immunol 182:2578–2582PubMedCrossRef

33.

Zheng Y, Josefowicz SZ, Kas A, Chu TT et al (2007) Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature 445:936–940PubMedCrossRef

34.

Ventura A et al (2008) Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell 132(5):875–886PubMedPubMedCentralCrossRef

35.

Mashreghi MF et al (2010) The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. Nat Immunol 11(11):1057–1062PubMedCrossRef

36.

Yasutomo K, Horiuchi T, Kagami S et al (2001) Mutation of DNASE1 in people with systemic lupus erythematosus. Nat Genet 28:313–314PubMedCrossRef

37.

Dai Y, Huang Y-S, Tang M et al (2007) Microarray analysis of microRNA expression in peripheral blood cells of systemic lupus erythematosus patients. Lupus 16:939–946PubMedCrossRef

38.

McMillan R (1981) Chronic idiopathic thrombocytopenic purpura. N Engl J Med 304:1135–1147PubMedCrossRef

39.

George J, Harake M, Aster R (1995) Thrombocytopenia due to enhanced platelet destruction by immunologic mechanisms. In: Beutler E, Lichtman MA, Coller BS, Kipps TJ (eds) Williams hematology, 5th ed. edn. McGraw-Hill, New York, pp 1315–1355

40.

Dai Y, Wang S, Lan H et al (2009) Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients. Rheumatol Int 29:749–754PubMedCrossRef

41.

Tang Y, Luo X et al (2009) Micro-RNA-146a contributes to abnormal activation of the type i interferon pathway in human lupus by targeting the key signaling proteins. Arthr Rheum 60:1065–1075CrossRef

42.

Liew FY, Xu D, Brint EK, O’Neill LA (2005) Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol 5:446–458PubMedCrossRef

43.

Balaci L, Spada MC, Olla N et al (2007) IRAK-M is involved in the pathogenesis of early-onset persistent asthma. Am J Hum Genet 80:1103–1114PubMedPubMedCentralCrossRef

44.

Fujimoto M, Tsutsui H, Xinshou O et al (2004) Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases. Int Immunol 16:303–314PubMedCrossRef

45.

Smolen JS, Aletaha D, Koeller M et al (2007) New therapies for treatment of rheumatoid arthritis. Lancet 370:1861–1874PubMedCrossRef

46.

Bresnihan B, Varo-Gracia JM, Cobby M et al (1998) Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arthr Rheum 41:2196–2204CrossRef

47.

Lipsky PE, Heijde DM, St Clair EW et al (2000) Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-tumor necrosis factor trial in rheumatoid arthritis with concomitant therapy study group. N Engl J Med 343:1594–1602PubMedCrossRef

48.

Stanczyk J, Pedrioli DM, Brentano F, Sanchez-Pernaute O, Kolling C, Gay RE et al (2008) Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthr Rheum 58:1001–1009CrossRef

49.

Kaleb MP et al (2008) Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthr Res Ther 10:R101CrossRef

50.

Yuji N, Kawano S, Takenokuchi M et al (2009) MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Arthr Rheum 60:1294–1304CrossRef

51.

Yoshihiko N, Nakasa T, Mochizuki Y et al (2009) Induction of apoptosis in the synovium of mice with autoantibody-mediated arthritis by the intraarticular injection of double-stranded microrna-15a. Arthr Rheum 60:2677–2683CrossRef

52.

Nakasa T, Miyaki S, Okubo A et al (2008) Expression of MicroRNA-146 in rheumatoid arthritis synovial tissue. Arthr Rheum 58:1284–1292CrossRef

53.

Otargui D, Baranzini SE, Armananzas R et al (2009) Differential micro RNA expression in PBMC from multiple sclerosis patients. PLOS ONE 4(7):e6309CrossRef

54.

Vallejo-Illarramendi A, Domercq M, Perez-Cerda F, Matute C et al (2006) Increased expression and function of glutamate transporters in multiple sclerosis. Neurobiol Dis 21:154–164PubMedCrossRef

55.

Matute C (2007) Interaction between glutamate signalling and immune attack in damaging oligodendrocytes. Neuron Glia Biol 3:281–285PubMedCrossRef

56.

Keller A, Leidinger P, Lange J et al (2009) Multiple sclerosis: microRNA expression profiles accurately differentiate patients with relapsing-remitting disease from healthy controls. PLOS ONE 4(10):e7440PubMedPubMedCentralCrossRef

57.

Du C, Liu C, Kang J et al (2009) MicroRNA miR-326 regulates T_H-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat Immunol 10:1252–1259PubMedCrossRef

58.

Tesmer L, Lundy A, Sarkar SK, Fox DA (2008) Th17 cells in human disease. Immunol Rev 223:87–113PubMedPubMedCentralCrossRef

Title: MicroRNAs in autoimmune disease
Authors: Vivek K. Rauniyar
Wei Wu
Huan Yang
Publication date: 01-11-2011
Publisher: Springer International Publishing
Published in: Autoimmunity Highlights / Issue 2/2011
Print ISSN: 2038-0305
Electronic ISSN: 2038-3274
DOI: https://doi.org/10.1007/s13317-011-0022-z

ACC 2024 Congress Coverage

Heart Failure Video

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

MicroRNAs in autoimmune disease

Abstract

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page