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Current Cardiovascular Imaging Reports

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01-10-2017 | Cardiac Nuclear Imaging (Alberto Cuocolo and Mario Petretta, Section Editors)

Quantification of Myocardial Blood Flow with CZT SPECT Imaging: Is It Ready for Clinical Use?

Authors: Fernanda Erthal, Ronaldo Lima, R Glenn Wells, Terrence D. Ruddy

Published in: Current Cardiovascular Imaging Reports | Issue 10/2017

Abstract

Purpose of Review

Myocardial blood flow (MBF) quantification with positron emission tomography (PET) is well validated and has established diagnostic and prognostic value for patient management. New cardiac dedicated solid-state single-photon emission tomography (SPECT) cameras using cadmium-zinc-telluride (CZT) crystals have better temporal and spatial resolution and increased count sensitivity than conventional SPECT systems and can measure MBF. We review recent validation studies using CZT technology for measurement of MBF and assess its readiness for clinical application.

Recent Findings

One preclinical study showed the accuracy of MBF measured using the CZT technology and conventional radiotracers versus microsphere data. Clinical studies have demonstrated the feasibility in patients and excellent correlations with coronary angiography and flow-wire studies, and PET imaging.

Summary

Measurement of MBF is possible with SPECT CZT systems and has been validated. Further studies are necessary to confirm the incremental value of MBF measurements with SPECT CZT to standard relative perfusion imaging for diagnostic accuracy and risk stratification.

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Title: Quantification of Myocardial Blood Flow with CZT SPECT Imaging: Is It Ready for Clinical Use?
Authors: Fernanda Erthal
Ronaldo Lima
R Glenn Wells
Terrence D. Ruddy
Publication date: 01-10-2017
Publisher: Springer US
Published in: Current Cardiovascular Imaging Reports / Issue 10/2017
Print ISSN: 1941-9066
Electronic ISSN: 1941-9074
DOI: https://doi.org/10.1007/s12410-017-9432-2

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