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Published in: Journal of Nuclear Cardiology 1/2017

01-02-2017 | Original Article

Comparison of the prognostic value of myocardial perfusion imaging using a CZT-SPECT camera with a conventional anger camera

Authors: Ronaldo Lima, MD, PhD, Thais Peclat, MD, Thalita Soares, BMBS, Caio Ferreira, BMBS, Ana Carolina Souza, BMBS, Gabriel Camargo, MD

Published in: Journal of Nuclear Cardiology | Issue 1/2017

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Abstract

Background

Recent studies have shown that myocardial perfusion imaging (MPI) in cadmium-zinc-telluride (CZT) cameras allow faster exams with less radiation dose but there are little data comparing its prognosis information with that of dedicated cardiac Na-I SPECT cameras

Objective

The objective of this study is to compare the prognostic value of MPI using an ultrafast protocol with low radiation dose in a CZT-SPECT and a traditional one.

Methods

Group 1 was submitted to a two-day MIBI protocol in a conventional camera, and group 2 was submitted to a 1-day MIBI protocol in CZT camera. MPI were classified as normal or abnormal, and perfusion scores were calculated. Propensity score matching methods were performed

Results

3554 patients were followed during 33±8 months. Groups 1 and 2 had similar distribution of age, gender, body mass index, risk factors, previous revascularization, and use of pharmacological stress. Group 1 had more abnormal scans, higher scores than group 2. Annualized hard events rate was higher in group 1 with normal scans but frequency of revascularization was similar to normal group 2. Patients with abnormal scans had similar event rates in both groups

Conclusion

New protocol of MPI in CZT-SPECT showed similar prognostic results to those obtained in dedicated cardiac Na-I SPECT camera, with lower prevalence of hard events in patients with normal scan.
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Literature
1.
go back to reference Gimelli A, Rossi G, Landi P, Marzullo P, Iervasi G, L’abbate A, et al. Stress/rest myocardial perfusion abnormalities by gated SPECT: Still the best predictor of cardiac events in stable ischemic heart disease. J Nucl Med. 2009;50(4):546–53.CrossRefPubMed Gimelli A, Rossi G, Landi P, Marzullo P, Iervasi G, L’abbate A, et al. Stress/rest myocardial perfusion abnormalities by gated SPECT: Still the best predictor of cardiac events in stable ischemic heart disease. J Nucl Med. 2009;50(4):546–53.CrossRefPubMed
2.
go back to reference Underwood SR, Godman B, Salyani S, Ogle JR, Ell PJ. Economics of myocardial perfusion imaging in Europe—the EMPIRE Study. Eur Heart J. 1999;20(2):157–66.CrossRefPubMed Underwood SR, Godman B, Salyani S, Ogle JR, Ell PJ. Economics of myocardial perfusion imaging in Europe—the EMPIRE Study. Eur Heart J. 1999;20(2):157–66.CrossRefPubMed
3.
go back to reference De Puey EG. Advances in SPECT camera software and hardware: Currently available and new on the horizon. J Nucl Cardiol. 2012;19(3):551–81.CrossRef De Puey EG. Advances in SPECT camera software and hardware: Currently available and new on the horizon. J Nucl Cardiol. 2012;19(3):551–81.CrossRef
4.
go back to reference Duvall WL, Croft LB, Ginsberg ES, Einstein AJ, Guma KA, George T, et al. Reduced isotope dose and imaging time with a high-efficiency CZT SPECT camera. J Nucl Cardiol. 2011;18(5):847–57.CrossRefPubMed Duvall WL, Croft LB, Ginsberg ES, Einstein AJ, Guma KA, George T, et al. Reduced isotope dose and imaging time with a high-efficiency CZT SPECT camera. J Nucl Cardiol. 2011;18(5):847–57.CrossRefPubMed
5.
go back to reference Herzog BA, Buechel RR, Katz R, Brueckner M, Husmann L, Burger IA, et al. Nuclear myocardial perfusion imaging with a cadmium-zinc-telluride detector technique: optimized protocol for scan time reduction. J Nucl Med. 2010;51(1):46–51.CrossRefPubMed Herzog BA, Buechel RR, Katz R, Brueckner M, Husmann L, Burger IA, et al. Nuclear myocardial perfusion imaging with a cadmium-zinc-telluride detector technique: optimized protocol for scan time reduction. J Nucl Med. 2010;51(1):46–51.CrossRefPubMed
6.
go back to reference Slomka PJ, Patton JA, Berman DS, Germano G. Advances in technical aspects of myocardial perfusion SPECT imaging. J Nucl Cardiol. 2009;16(2):255–76.CrossRefPubMed Slomka PJ, Patton JA, Berman DS, Germano G. Advances in technical aspects of myocardial perfusion SPECT imaging. J Nucl Cardiol. 2009;16(2):255–76.CrossRefPubMed
7.
go back to reference De Lorenzo A, Peclat T, Amaral AC, Lima RSL. Prognostic evaluation in obese patients using a dedicated multipinhole cadmium-zinc telluride SPECT camera. Int J Cardiovasc Imaging. 2015;2015:1–7. De Lorenzo A, Peclat T, Amaral AC, Lima RSL. Prognostic evaluation in obese patients using a dedicated multipinhole cadmium-zinc telluride SPECT camera. Int J Cardiovasc Imaging. 2015;2015:1–7.
8.
go back to reference Diamond GA, Forrester JS, Hirsch M, Staniloff HM, Vas R, Berman DS, et al. Application of conditional probability analysis to the clinical diagnosis of coronary artery disease. J Clin Investig. 1980;65(5):1210–21.CrossRefPubMedPubMedCentral Diamond GA, Forrester JS, Hirsch M, Staniloff HM, Vas R, Berman DS, et al. Application of conditional probability analysis to the clinical diagnosis of coronary artery disease. J Clin Investig. 1980;65(5):1210–21.CrossRefPubMedPubMedCentral
9.
go back to reference Lima R, De Lorenzo A, Camargo G, Oliveira G, Reis T, Peclat T, et al. Prognostic value of myocardium perfusion imaging with a new reconstruction algorithm. J Nucl Cardiol. 2014;21(1):149–57.CrossRefPubMed Lima R, De Lorenzo A, Camargo G, Oliveira G, Reis T, Peclat T, et al. Prognostic value of myocardium perfusion imaging with a new reconstruction algorithm. J Nucl Cardiol. 2014;21(1):149–57.CrossRefPubMed
10.
go back to reference Henzlova MJ, Cerqueira MD, Hansen CL, Taillefer R, Yao S-S. ASNC imaging guidelines for nuclear cardiology procedures: stress protocols and tracers. J Nucl Cardiol. 2009. doi:10.1007/s12350-009-9062-4. Henzlova MJ, Cerqueira MD, Hansen CL, Taillefer R, Yao S-S. ASNC imaging guidelines for nuclear cardiology procedures: stress protocols and tracers. J Nucl Cardiol. 2009. doi:10.​1007/​s12350-009-9062-4.
11.
go back to reference Lima R, Peclat T, Amaral AC, Nakamoto A, Lavagnoli D, De Lorenzo A. Preliminary data on the prognostic value of a new protocol of ultra-fast myocardial scintigraphy with less radiation in CZT gamma camera. Arq Bras Cardiol: Im Cardiov. 2016;29(1):11–6. Lima R, Peclat T, Amaral AC, Nakamoto A, Lavagnoli D, De Lorenzo A. Preliminary data on the prognostic value of a new protocol of ultra-fast myocardial scintigraphy with less radiation in CZT gamma camera. Arq Bras Cardiol: Im Cardiov. 2016;29(1):11–6.
12.
go back to reference Thygesen K, Alpert JS, White HD. Universal definitions of myocardial infarction. J Am Coll Cardiol. 2007;50:2173–95.CrossRefPubMed Thygesen K, Alpert JS, White HD. Universal definitions of myocardial infarction. J Am Coll Cardiol. 2007;50:2173–95.CrossRefPubMed
13.
go back to reference Douglas PS, Hendel RC, Cummings JE, Dent JM, Hodgson JM, Hoffmann U, et al. ACCF/ACR/AHA/ASE/ASNC/HRS/NASCI/RSNA/SAIP/SCAI/SCCT/SCMR 2008 Health Policy Statement on Structured Reporting in Cardiovascular Imaging. J Am Coll Cardiol. 2009;53:76–90.CrossRefPubMed Douglas PS, Hendel RC, Cummings JE, Dent JM, Hodgson JM, Hoffmann U, et al. ACCF/ACR/AHA/ASE/ASNC/HRS/NASCI/RSNA/SAIP/SCAI/SCCT/SCMR 2008 Health Policy Statement on Structured Reporting in Cardiovascular Imaging. J Am Coll Cardiol. 2009;53:76–90.CrossRefPubMed
14.
go back to reference Sharir T, Pinskiy M, Pardes A, Rochman A, Prokhorov V, Kovalski G, et al. Comparison of the diagnostic accuracies of very low stress-dose with standard-dose myocardial perfusion imaging: Automated quantification of one-day, stress-first SPECT using a CZT camera. J Nucl Card. 2016;23(1):11–20.CrossRef Sharir T, Pinskiy M, Pardes A, Rochman A, Prokhorov V, Kovalski G, et al. Comparison of the diagnostic accuracies of very low stress-dose with standard-dose myocardial perfusion imaging: Automated quantification of one-day, stress-first SPECT using a CZT camera. J Nucl Card. 2016;23(1):11–20.CrossRef
15.
go back to reference Gimelli A, Bottai M, Giorgetti A, Genovesi D, Kusch A, Ripoli A, et al. Comparison between ultrafast and standard single-photon emission CT in patients with coronary artery disease: a pilot study. Circ Cardiovasc Imaging. 2011;4(1):51–8.CrossRefPubMed Gimelli A, Bottai M, Giorgetti A, Genovesi D, Kusch A, Ripoli A, et al. Comparison between ultrafast and standard single-photon emission CT in patients with coronary artery disease: a pilot study. Circ Cardiovasc Imaging. 2011;4(1):51–8.CrossRefPubMed
16.
17.
go back to reference Yokota S, Mouden M, Ottervanger JP, Engbers E, Knollema S, Timmer JR, et al. Prognostic value of normal stress-only myocardial perfusion imaging: a comparison between conventional and CZT-based SPECT. Eur J Nucl Med Mol Imaging. 2016;43(2):296–301.CrossRefPubMed Yokota S, Mouden M, Ottervanger JP, Engbers E, Knollema S, Timmer JR, et al. Prognostic value of normal stress-only myocardial perfusion imaging: a comparison between conventional and CZT-based SPECT. Eur J Nucl Med Mol Imaging. 2016;43(2):296–301.CrossRefPubMed
Metadata
Title
Comparison of the prognostic value of myocardial perfusion imaging using a CZT-SPECT camera with a conventional anger camera
Authors
Ronaldo Lima, MD, PhD
Thais Peclat, MD
Thalita Soares, BMBS
Caio Ferreira, BMBS
Ana Carolina Souza, BMBS
Gabriel Camargo, MD
Publication date
01-02-2017
Publisher
Springer US
Published in
Journal of Nuclear Cardiology / Issue 1/2017
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-016-0618-9

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