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European Radiology
Published in: European Radiology 7/2014

01-07-2014 | Cardiac

Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with 15O-H2O PET

Authors: Yasuka Kikuchi, Noriko Oyama-Manabe, Masanao Naya, Osamu Manabe, Yuuki Tomiyama, Tsukasa Sasaki, Chietsugu Katoh, Kohsuke Kudo, Nagara Tamaki, Hiroki Shirato

Published in: European Radiology | Issue 7/2014

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Abstract

Objectives

This study introduces a method to calculate myocardium blood flow (MBF) and coronary flow reserve (CFR) using the relatively low-dose dynamic 320-row multi-detector computed tomography (MDCT), validates the method against 15O-H2O positron-emission tomography (PET) and assesses the CFRs of coronary artery disease (CAD) patients.

Methods

Thirty-two subjects underwent both dynamic CT perfusion (CTP) and PET perfusion imaging at rest and during pharmacological stress. In 12 normal subjects (pilot group), the calculation method for MBF and CFR was established. In the other 13 normal subjects (validation group), MBF and CFR obtained by dynamic CTP and PET were compared. Finally, the CFRs obtained by dynamic CTP and PET were compared between the validation group and CAD patients (n = 7).

Results

Correlation between MBF of MDCT and PET was strong (r = 0.95, P < 0.0001). CFR showed good correlation between dynamic CTP and PET (r = 0.67, P = 0.0126). CFRCT in the CAD group (2.3 ± 0.8) was significantly lower than that in the validation group (5.2 ± 1.8) (P = 0.0011).

Conclusions

We established a method for measuring MBF and CFR with the relatively low-dose dynamic MDCT. Lower CFR was well demonstrated in CAD patients by dynamic CTP.

Key Points

• MBF and CFR can be calculated using dynamic CTP with 320-row MDCT.
• MBF and CFR showed good correlation between dynamic CTP and PET.
• Lower CFR was well demonstrated in CAD patients by dynamic CTP.
Appendix
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Metadata
Title
Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with 15O-H2O PET
Authors
Yasuka Kikuchi
Noriko Oyama-Manabe
Masanao Naya
Osamu Manabe
Yuuki Tomiyama
Tsukasa Sasaki
Chietsugu Katoh
Kohsuke Kudo
Nagara Tamaki
Hiroki Shirato
Publication date
01-07-2014
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 7/2014
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-014-3164-3

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