Top

European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-02-2015 | Editorial

Dynamic SPECT: evolution of a widely available tool for the assessment of coronary flow reserve

Authors: Simona Ben-Haim, Denis Agostini

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 2/2015

Excerpt

Myocardial perfusion imaging (MPI) SPECT is well established in the diagnosis, monitoring response to treatment and risk stratification in patients with known or suspected coronary artery disease (CAD). PET enables quantitative assessment of myocardial blood flow (MBF, in millilitres per gram per minute) and coronary flow reserve (CFR), and quantification with ¹⁵O-water, ¹³N-ammonia and recently ⁸²Rb has been validated over a wide range of blood flows in animal models and humans [1‐4]. Quantitative assessment of MBF has been shown to improve the diagnostic accuracy of conventional MPI with SPECT or PET, to improve cardiac risk assessment and to predict outcome [5‐7]. Quantitation of MBF enables absolute assessment of myocardial flow and vasodilator reserve without the assumption of a normal reference region [8]. Therefore, the limitation of conventional MPI (underestimation of the extent and severity of multivessel CAD, when tracer uptake in the best-perfused myocardial region does not represent normally perfused myocardium) can be overcome by the use of absolute quantitation [9]. …

Hutchins GD, Schwaiger M, Rosenspire KC, Krivokapich J, Schelbert H, Kuhl DE. Noninvasive quantification of regional blood flow in the human heart using N-13 ammonia and dynamic positron emission tomography imaging. J Am Coll Cardiol. 1990;15:1032–42.PubMedCrossRef

Lortie M, Beanlands RS, Yoshinaga K, Klein R, DaSilva JN, DeKemp RA. Quantification of myocardial blood flow with 82-Rb dynamic PET imaging. Eur J Nucl Med Mol Imaging. 2007;43:1765–74.CrossRef

El Fakhri G, Karan A, Sitek A, Dorbala S, Abi-Hatem N, Lahoud Y, et al. Reproducibility and accuracy of quantitative myocardial blood flow assessment with (82)Rb PET: comparison with N-13 ammonia PET. J Nucl Med. 2009;50:1062–71.PubMedCentralPubMedCrossRef

Tahari AK, Lee A, Rajaram M, Fukushima K, Lodge MA, Lee BC, et al. Absolute myocardial flow quantification with 82Rb PET-CT: comparison of different software packages and methods. Eur J Nucl Med Mol Imaging. 2014;41:126–35.PubMedCrossRef

Murthy VL, Naya M, Foster CR, Hainer J, Gaber M, Di Carli G, et al. Improved cardiac risk assessment with noninvasive measures of coronary flow reserve. Circulation. 2011;124:2215–24.PubMedCentralPubMedCrossRef

Naya M, Murthy VL, Taqueti VR, Foster CR, Klein J, Garber M, et al. Preserved coronary flow reserve effectively excludes high-risk coronary artery disease on angiography. J Nucl Med. 2014;55:248–55.PubMedCentralPubMedCrossRef

Ziadi MC, DeKemp RA, Williams KA, Guo A, Chow BJ, Renaud JM, et al. Impaired myocardial flow reserve on rubidium-82 positron emission tomography imaging predicts adverse outcomes in patients assessed for myocardial ischemia. J Am Coll Cardiol. 2011;58:740–8.PubMedCrossRef

Gould KL, Lipskomb K, Hamilton GW. Physiologic basis for assessing critical coronary stenosis. Instantaneous flow response and regional distribution during coronary hyperemia as measures of coronary flow reserve. Am J Cardiol. 1974;33:87–94.PubMedCrossRef

Murthy VL, Di Carli MF. Non-invasive quantification of coronary vascular dysfunction for diagnosis and management of coronary artery disease. J Nucl Cardiol. 2012;19:1060–72.PubMedCrossRef

10.

Iida H, Eberl S, Kim KM, Tamura Y, Ono Y, Nakazawa M, et al. Absolute quantitation of myocardial blood flow with 201Tl and dynamic SPECT in canine: optimization and validation ok kinetic modeling. Eur J Nucl Med Mol Imaging. 2008;35:896–905.PubMedCrossRef

11.

Smith AM, Gullberg GT, Christian PE, Datz FL. Kinetic modelling of teboroxime using dynamic SPECT imaging of a canine model. J Nucl Med. 1994;35:484–95.PubMed

12.

Di Bella EV, Ross SG, Kadrmas DJ, Khare HS, Christian PE, McJames S, et al. Compartmental modeling of technetium-99m-labeled teboroxime with dynamic single-photon emission computed tomography: comparison with static thallium-201 in a canine model. Invest Radiol. 2001;36:178–85.PubMedCentralPubMedCrossRef

13.

Daniele S, Nappi C, Acampa W. Incremental prognostic value of coronary flow reserve assessed with single-photon emission computed tomography. J Nucl Cardiol. 2011;18:612–9.PubMedCrossRef

14.

Ito Y, Katoh C, Noriyasu K, Kuge Y, Furuyama H, Morita K, et al. Estimation of myocardial blood flow and myocardial flow reserve by 99mTc-sestamibi imaging: comparison with the results of O-15 H2O PET. Eur J Nucl Med Mol Imaging. 2003;30:281–7.PubMedCrossRef

15.

DeKemp RA, Trottier M, Beanlands RSB. Incremental prognostic value of coronary flow reserve assessed with single-photon emission computed tomography. J Nucl Cardiol. 2011;18:541–3.PubMedCrossRef

16.

Gambhir SS, Berman DS, Ziffer J, Nagler M, Sandler M, Patton J, et al. A novel high-sensitivity rapid-acquisition single-photon cardiac imaging camera. J Nucl Med. 2009;50:635–43.PubMedCrossRef

17.

Imbert L, Poussier S, Franken PR, Songy B, Verger A, Morel O, et al. Compared performance of high-sensitivity cameras dedicated to myocardial perfusion SPECT: a comprehensive analysis of phantom and human images. J Nucl Med. 2012;53:1897–903.PubMedCrossRef

18.

Verger A, Djaballah W, Fourquet N, Rouzet F, Koehl G, Imbert L, et al. Comparison between stress myocardial perfusion SPECT recorded with cadmium-zinc-telluride and Anger cameras in various study protocols. Eur J Nucl Med Mol Imaging. 2013;40:331–40.PubMedCrossRef

19.

Verger A, Imbert L, Yagdigul Y, Fay R, Djaballah W, Rouzet F, et al. Factors affecting the myocardial activity acquired during exercise SPECT with a high-sensitivity cardiac CZT camera as compared with conventional Anger camera. Eur J Nucl Med Mol Imaging. 2014;41:552–28.CrossRef

20.

Ben-Haim S, Murthy VL, Breault C, Allie R, Sitek A, Roth N, et al. Quantification of myocardial perfusion reserve using dynamic SPECT imaging in humans: a feasibility study. J Nucl Med. 2013;54:873–9.PubMedCentralPubMedCrossRef

21.

Wells RG, Timmins R, Klein R, Lockwood J, Marvin B, deKemp RA, et al. Dynamic SPECT measurement of absolute myocardial blood flow in porcine model. J Nucl Med. 2014. doi: 10.2967/jnumed.114.139782

22.

Gimelli A, Bottai M, Giorgetti A, Genovesi D, Filidei E, Marzullo P. Evaluation of ischaemia in obese patients: feasibility and accuracy of a low-dose protocol with a cadmium-zinc telluride camera. Eur J Nucl Med Mol Imaging. 2012;39:1254–61.PubMedCrossRef

23.

Einstein AJ, Blankstein R, Andrews H, Fish M, Padgett R, Hayes SW, et al. Comparison of image quality, myocardial perfusion and left ventricular function between standard imaging and single-injection ultra-low-dose imaging using a high-efficiency SPECT camera: the MILLISIEVERT study. J Nucl Med. 2014;55:1430–7.PubMedCrossRef

Title: Dynamic SPECT: evolution of a widely available tool for the assessment of coronary flow reserve
Authors: Simona Ben-Haim
Denis Agostini
Publication date: 01-02-2015
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 2/2015
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-014-2929-x

ACC 2024 Congress

Springer Medicine

Dynamic SPECT: evolution of a widely available tool for the assessment of coronary flow reserve

Excerpt

ACC 2024 Congress

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 2/2015

Prospective comparison of whole-body 18F-FDG PET/CT and MRI of the spine in the diagnosis of haematogenous spondylodiscitis: response to comments by Soussan

Lonie R. Salkowski: RadCases breast imaging

[68Ga]PSMA-HBED uptake mimicking lymph node metastasis in coeliac ganglia: an important pitfall in clinical practice

FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0

Pier Francesco Rambaldi: Whole-body FDG PET Imaging in Oncology—Clinical Reports

Prospective evaluation of a new protocol for the provisional use of perfusion imaging with exercise stress testing