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Current Cardiovascular Imaging Reports
Published in: Current Cardiovascular Imaging Reports 1/2010

01-02-2010 | Clinical Trial Report

The ATHEROMA Study: Rapid Anti-inflammatory Effects of High-Dose Statin Pharmacotherapy Illuminated by Molecular MRI

Authors: William J. Hucker, Farouc A. Jaffer

Published in: Current Cardiovascular Imaging Reports | Issue 1/2010

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Excerpt

Tang TY, Howarth SPS, Miller SR, et al.: The ATHEROMA (Atorvastatin Therapy: Effects on Reduction of Macrophage Activity) Study. Evaluation using ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging in carotid disease. J Am Coll Cardiol 2009, 53:2039–2050. …
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Schwartz GG, Olsson AG, Ezekowitz MD, et al.; Myocardial Ischemia Reduction With Aggressive Cholesterol Lowering (MIRACL) Study Investigators: Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial. JAMA 2001, 285:1711–1718.CrossRefPubMed
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Ray KK, Cannon CP, McCabe CH, et al.; PROVE IT-TIMI 22 Investigators: Early and late benefits of high-dose atorvastatin in patients with acute coronary syndromes: results from the PROVE IT-TIMI 22 trial. J Am Coll Cardiol 2005, 46:1405–1410.CrossRefPubMed
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Lindsay AC, Choudhury RP: Form to function: current and future roles for atherosclerosis imaging in drug development. Nat Rev Drug Discov 2008, 7:517–529.CrossRefPubMed
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Tahara N, Kai H, Ishibashi M, et al.: Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography. J Am Coll Cardiol 2006, 48:1825–1831.CrossRefPubMed
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Kooi ME, Cappendijk VC, Cleutjens KB, et al.: Accumulation of ultrasmall superparamagnetic particles of iron oxide in human atherosclerotic plaques can be detected by in vivo magnetic resonance imaging. Circulation 2003, 107:2453–2458.CrossRefPubMed
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Fayad ZA, Razzouk L, Briley-Saebo KC, Mani V: Iron oxide magnetic resonance imaging for atherosclerosis therapeutic evaluation: still “rusty”? J Am Coll Cardiol 2009, 53:2051–2052.CrossRefPubMed
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Weissleder R, Elizondo G, Wittenberg J, et al.: Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging. Radiology 1990, 175:489–493.PubMed
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Jaffer FA, Libby P, Weissleder R: Molecular imaging of cardiovascular disease. Circulation 2007, 116:1052–1061.CrossRefPubMed
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Jaffer FA, Vinegoni C, John MC, et al.: Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis. Circulation 2008, 118:1802–1809.CrossRefPubMed
Metadata
Title
The ATHEROMA Study: Rapid Anti-inflammatory Effects of High-Dose Statin Pharmacotherapy Illuminated by Molecular MRI
Authors
William J. Hucker
Farouc A. Jaffer
Publication date
01-02-2010
Publisher
Current Science Inc.
Published in
Current Cardiovascular Imaging Reports / Issue 1/2010
Print ISSN: 1941-9066
Electronic ISSN: 1941-9074
DOI
https://doi.org/10.1007/s12410-009-9003-2

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