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Clinical Journal of Gastroenterology
Published in: Clinical Journal of Gastroenterology 3/2020

01-06-2020 | Herpes Virus | Case Report

Multiple esophageal ulcers due to tofacitinib 10 mg twice daily for ulcerative colitis

Authors: Keiichi Tominaga, Mimari Kanazawa, Kazuhiro Takenaka, Takanao Tanaka, Takeshi Sugaya, Koh Fukushi, Yuka Takagi, Kazunori Nagashima, Keiichiro Abe, Naoya Izawa, Kohei Tsuchida, Makoto Iijima, Kenichi Goda, Hidetsugu Yamagishi, Atsushi Irisawa

Published in: Clinical Journal of Gastroenterology | Issue 3/2020

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Abstract

A 26-year-old man was admitted to our institution for ulcerative colitis treatment. He used mesalamine, steroid, immunomodulators, and anti-TNFα anti-body, but it was difficult to maintain remission. We started induction therapy with tofacitinib (TOF) 10 mg twice daily. He maintained clinical remission but had chest pain 44 days after the start of TOF. Esophagogastroduodenoscopy showed multiple ulcers from middle to lower esophagus. Although rare, TOF induced esophageal ulcers were considered based on his clinical course and endoscopic findings.
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Sandborn WJ, Su C, Sands BE, et al. Tofacitinib as induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2017;376:1723–36.CrossRef
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Winthrop KL, Melmed GY, Vermeire S, et al. Herpes zoster infection in patients with ulcerative colitis receiving tofacitinib. Inflamm Bowel Dis. 2018;24:2258–65.CrossRef
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Motoya S, Watanabe M, Kim HJ, et al. Tofacitinib induction and maintenance therapy in East Asian patients with active ulcerative colitis: subgroup analyses from three phase 3 multinational studies. Intest Res. 2018;16:233–45.CrossRef
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Metadata
Title
Multiple esophageal ulcers due to tofacitinib 10 mg twice daily for ulcerative colitis
Authors
Keiichi Tominaga
Mimari Kanazawa
Kazuhiro Takenaka
Takanao Tanaka
Takeshi Sugaya
Koh Fukushi
Yuka Takagi
Kazunori Nagashima
Keiichiro Abe
Naoya Izawa
Kohei Tsuchida
Makoto Iijima
Kenichi Goda
Hidetsugu Yamagishi
Atsushi Irisawa
Publication date
01-06-2020
Publisher
Springer Singapore
Published in
Clinical Journal of Gastroenterology / Issue 3/2020
Print ISSN: 1865-7257
Electronic ISSN: 1865-7265
DOI
https://doi.org/10.1007/s12328-019-01061-y

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