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Current Reviews in Musculoskeletal Medicine
Published in: Current Reviews in Musculoskeletal Medicine 3/2019

01-09-2019 | Knee Osteoarthritis | Outcomes Research in Orthopedics (O Ayeni, Section Editor)

The Clinical Use of Biologics in the Knee Lesions: Does the Patient Benefit?

Authors: Ibrahim Fatih Cengiz, Hélder Pereira, João Espregueira-Mendes, Rui L. Reis, Joaquim Miguel Oliveira

Published in: Current Reviews in Musculoskeletal Medicine | Issue 3/2019

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Abstract

Purpose of Review

Overview the outcomes of the latest use of platelet-rich plasma (PRP) for the treatment of knee lesions in the clinics and discuss the challenges and limitations.

Recent Findings

Recent clinical studies mainly indicate there may be benefit of PRP usage for the treatment of knee lesions. As an autologous source of bioactive components, PRP has been shown to be typically safe, free of major adverse outcomes. The use of PRP has been continuously increasing, and some well-designed, double-blinded, placebo-controlled clinical trials have been published.

Summary

Clinical outcomes relating to PRP usage are multifactorial and depend on the severity of the lesion and patient characteristics. Although PRP is safe to use and it can be easily applied in the clinics, case-specific considerations are needed to determine whether PRP could be beneficial or not. If the use of PRP is favored, then, the configuration/optimization of the preparation and administration/delivery strategy with or without a concomitant treatment may further enhance the clinical outcomes and patients’ experience.
Appendix
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Metadata
Title
The Clinical Use of Biologics in the Knee Lesions: Does the Patient Benefit?
Authors
Ibrahim Fatih Cengiz
Hélder Pereira
João Espregueira-Mendes
Rui L. Reis
Joaquim Miguel Oliveira
Publication date
01-09-2019
Publisher
Springer US
Published in
Current Reviews in Musculoskeletal Medicine / Issue 3/2019
Electronic ISSN: 1935-9748
DOI
https://doi.org/10.1007/s12178-019-09573-3

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